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Research ArticleExperimental Studies

Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling

HIROSHI HOTTA, KAZUNORI HAMAMURA, HIDENOBU SHIBUYA, YUHSUKE OHMI, KEIKO FURUKAWA and KOICHI FURUKAWA
Anticancer Research April 2021, 41 (4) 1821-1830; DOI: https://doi.org/10.21873/anticanres.14948
HIROSHI HOTTA
1Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan;
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KAZUNORI HAMAMURA
2Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya, Japan;
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  • For correspondence: hamak@dpc.agu.ac.jp
HIDENOBU SHIBUYA
1Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan;
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YUHSUKE OHMI
3Department of Clinical Engineering, Chubu University College of Life and Health Sciences, Kasugai, Japan;
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KEIKO FURUKAWA
4Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan
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KOICHI FURUKAWA
1Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan;
4Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan
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Abstract

Background/Aim: Lewis y is expressed in oral squamous cell carcinoma (OSCC) cells and tumors. Previously, we reported that Lewis y was not expressed in invasion areas, and attenuation of proliferation and invasion in OSCC cells was caused by over-expression of Lewis y. However, the roles of Lewis y in the attenuation of malignant properties have not been clarified. In this study, we investigated the roles of Lewis y in OSCC. Materials and Methods: The levels of Lewis y on EGFR and the phosphorylation levels of EGFR in OSCC cells were analyzed by immunoprecipitation and western blot. EGFR cross-linking and binding kinetics of EGF were performed. Results: Upon EGF stimulation, phosphorylation and dimer formation of EGFR were more prominent in Lewis y– cells. EGF binding kinetics showed reduced binding sites in Lewis y+ cells. Conclusion: Lewis y reduced EGF binding to EGFR, leading to suppression of malignant properties through suppression of EGF signaling.

Key Words:
  • Lewis y
  • squamous cell carcinoma
  • epidermal growth factor receptor
  • Received February 10, 2021.
  • Revision received February 24, 2021.
  • Accepted February 25, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (4)
Anticancer Research
Vol. 41, Issue 4
April 2021
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Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling
HIROSHI HOTTA, KAZUNORI HAMAMURA, HIDENOBU SHIBUYA, YUHSUKE OHMI, KEIKO FURUKAWA, KOICHI FURUKAWA
Anticancer Research Apr 2021, 41 (4) 1821-1830; DOI: 10.21873/anticanres.14948

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Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling
HIROSHI HOTTA, KAZUNORI HAMAMURA, HIDENOBU SHIBUYA, YUHSUKE OHMI, KEIKO FURUKAWA, KOICHI FURUKAWA
Anticancer Research Apr 2021, 41 (4) 1821-1830; DOI: 10.21873/anticanres.14948
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Keywords

  • Lewis y
  • squamous cell carcinoma
  • epidermal growth factor receptor
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