Table of Contents

Clinical Studies

• Open Access

  Novel Preoperative Patient-centered Surgical Wellness Program Impacts Length of Stay Following Pancreatectomy

  MAZHAR SOUFI, DANIELLE K. DEPERALTA, RACHEL SIMPSON, KATELYN FLICK, MICHELE T. YIP-SCHNEIDER, CHRISTIAN M. SCHMIDT, MOLLY KILBANE, CAMERON COLGATE, KRISTEN E. KELLEY, WILLIAM WOODEN, EUGENE P. CEPPA, MICHAEL HOUSE, NICHOLAS ZYROMSKI, ATILLA NAKEEB and C. MAX SCHMIDT

  Anticancer Research April 2021, 41 (4) 1895-1901; DOI: https://doi.org/10.21873/anticanres.14955
• Open Access

  The Impact of the COVID-19 Pandemic on Breast Reconstruction Practices in the United States

  WALTER J. JOSEPH, SAMYD S. BUSTOS, JOSEPH E. LOSEE, J. PETER RUBIN and CAROLYN DE LA CRUZ

  Anticancer Research April 2021, 41 (4) 1903-1908; DOI: https://doi.org/10.21873/anticanres.14956
• Open Access

  Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge

  FELIX ZWICKER, SEBASTIAN HOEFEL, CORINNA KIRCHNER, PETER E. HUBER, JUERGEN DEBUS and MICHAEL SCHEMPP

  Anticancer Research April 2021, 41 (4) 1909-1920; DOI: https://doi.org/10.21873/anticanres.14957
• Open Access

  Lowering and Stabilizing PSA Levels in Advanced-prostate Cancer Patients With Oral Methioninase

  QINGHONG HAN and ROBERT M. HOFFMAN

  Anticancer Research April 2021, 41 (4) 1921-1926; DOI: https://doi.org/10.21873/anticanres.14958
• Open Access

  CT Attenuation and Cross-sectional-area Index of the Pectoralis Are Associated With Prognosis in Sarcoma Patients

  STEPHANIE JO and RONNIE SEBRO

  Anticancer Research April 2021, 41 (4) 1927-1935; DOI: https://doi.org/10.21873/anticanres.14959
• Open Access

  Have Volume-based Parameters of Positron Emission Tomography/Computed Tomography Prognostic Relevance for Patients With Potentially Platinum-responsive Recurrent Ovarian Cancer? A Single Center Italian Study

  ANGIOLO GADDUCCI, ENRICO SIMONETTI, FEDERICA GUIDOCCIO, GIANPIERO MANCA, ASSUERO GIORGETTI, TOMMASO DEPALO, STEFANIA COSIO, MARIO MICCOLI and DUCCIO VOLTERRANI

  Anticancer Research April 2021, 41 (4) 1937-1944; DOI: https://doi.org/10.21873/anticanres.14960
• Open Access

  Colon or Rectal Stent Positioning for Advanced Cancer Influences Quality of Life: A Critical Point of View

  ENRICO FIORI, DANIELE CROCETTI, PAOLO SAPIENZA, MICHELANGELO MICCINI, ROBERTO CIROCCHI, ANTONIO V. STERPETTI, FRANCESCA DE FELICE, SILVANO COSTI, GIOIA BRACHINI, ANDREA MINGOLI, ANTONIETTA LAMAZZA and GIORGIO DE TOMA

  Anticancer Research April 2021, 41 (4) 1945-1950; DOI: https://doi.org/10.21873/anticanres.14961
• Open Access

  Dosimetric Comparison of Radiation Therapy Using Hybrid-VMAT Technique for Stage I Esophageal Cancer

  YOSUKE TAKAKUSAGI, TERUFUMI KUSUNOKI, KIO KANO, WATARU ANNO, KEISUKE TSUCHIDA, NOBUTAKA MIZOGUCHI, ITSUKO SERIZAWA, HIROYUKI KATOH, TADASHI KAMADA, TAKATOMO EZURA, KATSUYUKI SHIRAI and DAISAKU YOSHIDA

  Anticancer Research April 2021, 41 (4) 1951-1958; DOI: https://doi.org/10.21873/anticanres.14962
• Open Access

  A Diagnostic Score for Acute Small Bowel Obstruction

  MAARET ESKELINEN, JANNICA MEKLIN, KARI SYRJÄNEN and MATTI ESKELINEN

  Anticancer Research April 2021, 41 (4) 1959-1970; DOI: https://doi.org/10.21873/anticanres.14963
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  Symptom Burden in Patients Treated With Palliative Radiotherapy Before and During the COVID-19 Pandemic

  CARSTEN NIEDER, SILJE K. JOHNSEN and ANNETTE M. WINTHER

  Anticancer Research April 2021, 41 (4) 1971-1974; DOI: https://doi.org/10.21873/anticanres.14964
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  Feasibility of Reductive Hepatectomy in Patients With BCLC B and C Hepatocellular Carcinoma

  YUKI YASUHARA, SHOHEI KOMATSU, KAORI KURAMITSU, MASAHIRO KIDO, MOTOFUMI TANAKA, HIDETOSHI GON, HIROAKI YANAGIMOTO, HIROCHIKA TOYAMA, TETSUO AJIKI and TAKUMI FUKUMOTO

  Anticancer Research April 2021, 41 (4) 1975-1983; DOI: https://doi.org/10.21873/anticanres.14965
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  Treatment Volume, Dose Prescription and Delivery Techniques for Dose-intensification in Rectal Cancer: A National Survey

  LUCIANA CARAVATTA, MARCO LUPATTELLI, GIOVANNA MANTELLO, MARIA ANTONIETTA GAMBACORTA, GIUDITTA CHILOIRO, MONICA DI TOMMASO, CONSUELO ROSA, LUCREZIA GASPARINI, ALESSIO GIUSEPPE MORGANTI, VINCENZO PICARDI, RITA MARINA NIESPOLO, MATTIA FALCHETTO OSTI, SABRINA MONTRONE, NICOLA SIMONI, CATERINA BOSO, FRANCESCA FACCHIN, MARIA ASSUNTA DEIDDA, CRISTINA PIVA, CESARE GUIDA, LUIGI ZICCARELLI, FERNANDO MUNOZ, GIOVANNI BATTISTA IVALDI, VANIA MARCHETTI, PAOLA FRANZONE, CORRADO SPATOLA, PIERFRANCESCO FRANCO, VITTORIO DONATO, DOMENICO GENOVESI and on behalf of Gastrointestinal Study Group of AIRO (Italian Association of Radiation Oncology and Clinical Oncology)

  Anticancer Research April 2021, 41 (4) 1985-1995; DOI: https://doi.org/10.21873/anticanres.14966
• Open Access

  Carbon-ion Radiotherapy for Oligometastatic Colorectal Cancer in the Liver or Lung

  SHINTARO SHIBA, KEI SHIBUYA, MASAHIKO OKAMOTO, NAOKO OKANO, NOBUTERU KUBO, TAKUYA KAMINUMA, HIRO SATO, SHOHEI OKAZAKI, YUHEI MIYASAKA, HIDEMASA KAWAMURA and TATSUYA OHNO

  Anticancer Research April 2021, 41 (4) 1997-2005; DOI: https://doi.org/10.21873/anticanres.14967
• Open Access

  Direct-acting Antiviral Therapy Improves the Outcome of Chronic Hepatitis C/intermediate-stage B Hepatocellular Carcinoma Patients

  CHANGHAN SHAO, PAUL P. SHAO, WEI-TING CHEN, CHENG-CHUN LIN, WEY-RAN LIN and CHAU-TING YEH

  Anticancer Research April 2021, 41 (4) 2007-2016; DOI: https://doi.org/10.21873/anticanres.14968
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  Retrospective Study of Radiotherapy Impact on the Outcome of Material-assisted Implant-based Subpectoral Breast Reconstruction

  RALF OHLINGER, FLORIAN NAWROTH, THOMAS KOHLMANN, ZAHER ALWAFAI, KATHARINA SCHUELER, MAREK ZYGMUNT and STEFAN PAEPKE

  Anticancer Research April 2021, 41 (4) 2017-2024; DOI: https://doi.org/10.21873/anticanres.14969
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  Liver Function in Older Patients With Unresectable Hepatocellular Carcinoma After Administration of Lenvatinib

  RYU SASAKI, MASANORI FUKUSHIMA, MASAFUMI HARAGUCHI, SATOSHI MIUMA, HISAMITSU MIYAAKI, MASAAKI HIDAKA, SUSUMU EGUCHI, SATOSHI MATSUO, TOSHIHISA MATSUZAKI, SATSUKI HASHIMOTO, KAZUO OHBA, YUKI KUGIYAMA, HIROSHI YATSUHASHI, HIDETAKA SHIBATA, YASUHIDE MOTOYOSHI, MASAYA SHIGENO, SHINICHI IWATSU, YUJI KATO, NOBORU KINOSHITA and KAZUHIKO NAKAO

  Anticancer Research April 2021, 41 (4) 2025-2032; DOI: https://doi.org/10.21873/anticanres.14970
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  Prognostic Value and Therapeutic Implications of Pleural Carcinosis and Malignant Pleural Effusion in Advanced Epithelial Ovarian Cancer

  SARA NASSER, CHRISTINA FOTOPOULOU, ROLF RICHTER, JANA KAULICH, ELENA BRAICU, CARMEN BETETA, JESSICA OLSCHEWSKI, AYGUN BABAYEVA and JALID SEHOULI

  Anticancer Research April 2021, 41 (4) 2033-2038; DOI: https://doi.org/10.21873/anticanres.14971
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  Value of Panendoscopy in the Identification of Synchronous Malignancies in Patients Suffering from Oral Squamous Cell Carcinoma Without Clinical Signs of a Second Primary Tumor

  STEFFEN KOERDT, JAN-DIRK RAGUSE, FELIX NEUMANN, BENEDICTA BECK-BROICHSITTER, KILIAN KREUTZER, KONRAD NEUMANN, MAX HEILAND and CHRISTIAN DOLL

  Anticancer Research April 2021, 41 (4) 2039-2044; DOI: https://doi.org/10.21873/anticanres.14972
• Open Access

  Modified TPEx as First-line Treatment for Recurrent and/or Metastatic Head and Neck Cancer

  MOTOYUKI SUZUKI, YUKINORI TAKENAKA, TOSHIHIRO KISHIKAWA, YOSHIFUMI YAMAMOTO, ATSUSHI HANAMOTO, YOICHIRO TOMIYAMA, TAKAHITO FUKUSUMI, TAKAHIRO MICHIBA, NORIHIKO TAKEMOTO, SUSUMU NAKAHARA and HIDENORI INOHARA

  Anticancer Research April 2021, 41 (4) 2045-2051; DOI: https://doi.org/10.21873/anticanres.14973
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  Prognostic Role for CYFRA 21-1 in Patients With Advanced-stage NSCLC Treated With Bevacizumab Plus Chemotherapy

  MARTIN SVATON, JIRI BLAZEK, GABRIELA KRAKOROVA, MILOS PESEK, MARCELA BURESOVA, ZUZANA TEUFELOVA, JOSEF VODICKA, KAROLINA HURDALKOVA, MAGDA BARINOVA and ONDREJ TOPOLCAN

  Anticancer Research April 2021, 41 (4) 2053-2058; DOI: https://doi.org/10.21873/anticanres.14974
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  Real-life Effectiveness of Afatinib Versus Gefitinib in Patients With Non-small-cell Lung Cancer: A Czech Multicentre Study

  MARTIN SVATON, MONIKA BRATOVA, ONDREJ FISCHER, JANA KREJCI, LEONA KOUBKOVA, MARKETA CERNOVSKA, MICHAL HRNCIARIK, MILADA ZEMANOVA, HELENA COUPKOVA, BEDRICH PORZER, DANIEL DOLEZAL, TANA TUZOVA, KAROLINA HURDALKOVA, MAGDA BARINOVA and JANA SKRICKOVA

  Anticancer Research April 2021, 41 (4) 2059-2065; DOI: https://doi.org/10.21873/anticanres.14975
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  Treatment Contraindications Based on Comorbidity Status in Patients With Melanoma in the United States

  DANIEL BOCZAR, SANJAY P. BAGARIA, AARON C. SPAULDING, MARIA T. HUAYLLANI, FRANCISCO R. AVILA, GUNEL GULIYEVA, XIAONA LU, BRIAN D. RINKER and ANTONIO J. FORTE

  Anticancer Research April 2021, 41 (4) 2067-2070; DOI: https://doi.org/10.21873/anticanres.14976
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  Efficacy of FOLFOX Chemotherapy in Metastatic Enteropancreatic Neuroendocrine Tumors

  SANDRINE OZIEL-TAIEB, CHRISTOPHE ZEMMOUR, JEAN-LUC RAOUL, LAURENT MINEUR, FLORA POIZAT, NATHALIE CHARRIER, GILLES PIANA, GERARD CAVAGLIONE and PATRICIA NICCOLI

  Anticancer Research April 2021, 41 (4) 2071-2078; DOI: https://doi.org/10.21873/anticanres.14977
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  Inflammatory Pseudotumor Resembling a Malignant Pancreatic Disease Process

  JAMIE KAPLAN, CATHERINE MANGUM, MIRA SHOUKRY and EMMANUEL GABRIEL

  Anticancer Research April 2021, 41 (4) 2079-2082; DOI: https://doi.org/10.21873/anticanres.14978
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  Microdont Developing Outside the Alveolar Process and Within Oral Diffuse and Plexiform Neurofibroma in Neurofibromatosis Type 1

  REINHARD E. FRIEDRICH, HANNAH T. SCHEUER, JOZEF ZUSTIN, ANDREAS M. LUEBKE, CHRISTIAN HAGEL and HANNA A. SCHEUER

  Anticancer Research April 2021, 41 (4) 2083-2092; DOI: https://doi.org/10.21873/anticanres.14979
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  Impact of Renin–angiotensin System Inhibitors on the Efficacy of Anti-PD-1/PD-L1 Antibodies in NSCLC Patients

  TAKEHIRO TOZUKA, NORIKO YANAGITANI, HIROSHI YOSHIDA, RYO MANABE, SHINSUKE OGUSU, RYOSUKE TSUGITOMI, HIROAKI SAKAMOTO, YOSHIAKI AMINO, RYO ARIYASU, KEN UCHIBORI, SATORU KITAZONO, MASAHIRO SEIKE, AKIHIKO GEMMA and MAKOTO NISHIO

  Anticancer Research April 2021, 41 (4) 2093-2100; DOI: https://doi.org/10.21873/anticanres.14980
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  How Much Daily Image-guided Volumetric Modulated Arc Therapy Is Useful for Proctitis Prevention With Respect to Static Intensity Modulated Radiotherapy Supported by Topical Medications Among Localized Prostate Cancer Patients?

  GIANLUCA FERINI, ANTONELLA TRIPOLI, LAURA MOLINO, ALBERTO CACCIOLA, SARA LILLO, SILVANA PARISI, VINCENZA UMINA, SALVATORE IVAN ILLARI, VALENTINA ANNA MARCHESE, IRENE RITA CRAVAGNO, GIUSEPPINA RITA BORZÌ and VITO VALENTI

  Anticancer Research April 2021, 41 (4) 2101-2110; DOI: https://doi.org/10.21873/anticanres.14981
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  Palliative Benefits of Oral Mifepristone for the Treatment of Metastatic Fibroblastic Osteosarcoma

  JEROME H. CHECK, DIANE CHECK, TRINA PORETTA and CARRIE WILSON

  Anticancer Research April 2021, 41 (4) 2111-2115; DOI: https://doi.org/10.21873/anticanres.14982
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  Clinical Significance of Stanniocalcin2 mRNA Expression in Patients With Colorectal Cancer

  TAKUO WATANABE, MANABU SHIOZAWA, YAYOI KIMURA, YUKIHIKO HIROSHIMA, ITARU HASHIMOTO, KEISUKE KOMORI, HAYATO WATANABE, KAZUKI KANO, HIROHITO FUJIKAWA, TORU AOYAMA, MASAKATSU NUMATA, TAKANOBU YAMADA, HIROSHI TAMAGAWA, TAKASHI OGATA, NORIO YUKAWA, SOICHIRO MORINAGA, YASUSHI RINO, MUNETAKA MASUDA, YOHEI MIYAGI and TAKASHI OSHIMA

  Anticancer Research April 2021, 41 (4) 2117-2122; DOI: https://doi.org/10.21873/anticanres.14983
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  Breast Textured Implants Determine Early T-helper Impairment: BIAL2.20 Study

  GIANLUCA VANNI, MARCO MATERAZZO, MARCO PELLICCIARO, SADRI AMIR, FEDERICO TACCONI, VINCENZO AMBROGI and ORESTE CLAUDIO BUONOMO

  Anticancer Research April 2021, 41 (4) 2123-2132; DOI: https://doi.org/10.21873/anticanres.14984
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  Molecular Characteristics of Lymphocyte-predominant Triple-negative Breast Cancer

  RITSUKO SASAKI, YOSHIYA HORIMOTO, YUKA YANAI, AIKO KURISAKI-ARAKAWA, ATSUSHI ARAKAWA, KATSUYA NAKAI, MITSUE SAITO and TSUYOSHI SAITO

  Anticancer Research April 2021, 41 (4) 2133-2140; DOI: https://doi.org/10.21873/anticanres.14985
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  Concurrent Chemoradiotherapy With Docetaxel, Cisplatin, and 5-Fluorouracil (DCF-RT) vs. Cisplatin and 5-Fluorouracil (CF-RT) for Patients With Unresectable Locally Advanced Esophageal Cancer in a Real-world Clinical Setting

  MAKOTO SAKAI, MAKOTO SOHDA, HIDEYUKI SAITO, NOBUHIRO NAKAZAWA, YASUNARI UBUKATA, KENGO KURIYAMA, KEIGO HARA, AKIHIKO SANO, HIROOMI OGAWA, TAKEHIKO YOKOBORI, KAZUTOSHI MURATA, SHIN-EI NODA, TATSUYA OHNO, KEN SHIRABE and HIROSHI SAEKI

  Anticancer Research April 2021, 41 (4) 2141-2145; DOI: https://doi.org/10.21873/anticanres.14986
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  Comparison of Inflammation-based Prognostic Scores in Patients With Biliary Tract Cancer After Surgical Resection

  MASASHI UTSUMI, KOJI KITADA, NAOYUKI TOKUNAGA, YUSUKE YOSHIDA, TORU NARUSAKA, RYOSUKE HAMANO, HIDEAKI MIYASOU, YOUSUKE TSUNEMITSU, SHINYA OTSUKA and MASARU INAGAKI

  Anticancer Research April 2021, 41 (4) 2147-2155; DOI: https://doi.org/10.21873/anticanres.14987
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  Prospective Multicenter Phase II Study of Biweekly TAS-102 and Bevacizumab for Metastatic Colorectal Cancer

  TETSUO ISHIZAKI, JUNICHI MAZAKI, MASANOBU ENOMOTO, MASATOSHI SHIGOKA, KENTA KASAHARA, TAKAAKI MATSUDO, HIDEAKI KAWAKITA, YUICHI NAGAKAWA, KENJI KATSUMATA and AKIHIKO TSUCHIDA

  Anticancer Research April 2021, 41 (4) 2157-2163; DOI: https://doi.org/10.21873/anticanres.14988
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  Tumor Size and N2 Lymph Node Metastasis Are Significant Risk Factors for Early Recurrence in Completely Resected Centrally Located Primary Lung Cancer Patients

  TAKUMA TSUKIOKA, NOBUHIRO IZUMI, HIROAKI KOMATSU, HIDETOSHI INOUE, HIKARU MIYAMOTO, RYUICHI ITO, TAKUYA KIMURA and NORITOSHI NISHIYAMA

  Anticancer Research April 2021, 41 (4) 2165-2169; DOI: https://doi.org/10.21873/anticanres.14989
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  Strategies to Perform Curative Laparoscopic Repeat Hepatectomy for Recurrent Liver Tumors After Open Right Lobectomy

  KENEI FURUKAWA, KOICHIRO HARUKI, JUNGO YASUDA, SHINJI ONDA, TOMOHIKO TANIAI, RYOGA HAMURA, HIRONORI SHIOZAKI, YOSHIHIRO SHIRAI, TOMONORI IIDA, TARO SAKAMOTO, TAKESHI GOCHO and TORU IKEGAMI

  Anticancer Research April 2021, 41 (4) 2171-2175; DOI: https://doi.org/10.21873/anticanres.14990
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  PBK Expression Is Associated With Prognosis of Patients With Oral Squamous Cell Carcinoma Treated With Radiotherapy: A Retrospective Study

  WAN-NIEN YU, HENG-FU LIN, YI LEE, WEI-CHUNG SHIA, WEN-WEI SUNG, CHUNG-MIN YEH and YUEH-MIN LIN

  Anticancer Research April 2021, 41 (4) 2177-2182; DOI: https://doi.org/10.21873/anticanres.14991
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  Usefulness of Biparametric Magnetic Resonance Imaging Combined With Prostate Specific Antigen Density in Pre-biopsy Detection of Clinically Insignificant Prostate Cancer

  SHO SEKITO, TAKASHI TERABE, TAKUJI SHIBAHARA and TAKEHISA ONISHI

  Anticancer Research April 2021, 41 (4) 2183-2186; DOI: https://doi.org/10.21873/anticanres.14992
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  Efficacy of Ramucirumab Versus Sorafenib as Subsequent Treatment for Hepatocellular Carcinoma

  KAZUKI MAESAKA, RYOTARO SAKAMORI, RYOKO YAMADA, YUKI TAHATA, KAZUYOSHI OHKAWA, MASAHIDE OSHITA, SHINJI TAMURA, HIDEKI HAGIWARA, EIJI MITA, TAKAYUKI YAKUSHIJIN, MASAMI INADA, TAKAHIRO KODAMA, HAYATO HIKITA, TOMOHIDE TATSUMI and TETSUO TAKEHARA

  Anticancer Research April 2021, 41 (4) 2187-2192; DOI: https://doi.org/10.21873/anticanres.14993
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  A Retrospective Analysis of Perioperative Chemotherapy and Coronavirus Disease in Patients With Breast Cancer

  KAZUMI HAYASHI, MIHO TAMURA, EIJIRO NAGASAKI, YUKIKO YOSHII, TAKAYUKI ISHIGAKI, TAKASHI KAZAMA, MAKIKO KAMIO, HIROKO NOGI, YASUO TORIUMI, HIROSHI TAKEYAMA and SHINGO YANO

  Anticancer Research April 2021, 41 (4) 2193-2195; DOI: https://doi.org/10.21873/anticanres.14994
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  Use of Transumbilical Incision as an Organ Removal Site in Laparoscopic Pancreatectomy

  KODAI TOMIOKA, MASAHIKO MURAKAMI, TAKESHI AOKI, KAZUHIRO MATSUDA, TOMOTAKE KOIZUMI, TOMOKAZU KUSANO, KOJI NOGAKI, YOSHIHIKO TASHIRO, YUSUKE WADA, TOMOKI HAKOZAKI, HIDEKI SHIBATA, TAKAHITO HIRAI, TATSUYA YAMAZAKI, KAZUHIKO SAITO, YOSHIHITO SATO, KIYOTAKA MOCHIZUKI, AKIRA FUJIMORI and YUTA ENAMI

  Anticancer Research April 2021, 41 (4) 2197-2201; DOI: https://doi.org/10.21873/anticanres.14995
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  Clinical Outcomes Following Trifluridine/Tipiracil Treatment for Patients With Metastatic Colorectal Cancer Ineligible for Regorafenib Treatment

  YUSUKE NIISATO, TOSHIKAZU MORIWAKI, SHOTA FUKUOKA, TOSHIKI MASUISHI, ATSUO TAKASHIMA, YOSUKE KUMEKAWA, TAKESHI KAJIWARA, KENTARO YAMAZAKI, TAITO ESAKI, AKITAKA MAKIYAMA, TADAMICHI DENDA, YUKIMASA HATACHI, TAKESHI SUTO, NAOTOSHI SUGIMOTO and YASUHIRO SHIMADA

  Anticancer Research April 2021, 41 (4) 2203-2207; DOI: https://doi.org/10.21873/anticanres.14996