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Research ArticleClinical Studies

Pathological Complete Remission of Liver Metastases Correlates With Elimination of Tumor-infiltrating Tregs in Gastric Cancer

YASUTAKA NAKANISHI, SEIICHI HIROTA, YUDAI HOJO, TATSURO NAKAMURA, TSUTOMU KUMAMOTO, YASUNORI KURAHASHI, YOSHINORI ISHIDA and HISASHI SHINOHARA
Anticancer Research March 2021, 41 (3) 1571-1577; DOI: https://doi.org/10.21873/anticanres.14917
YASUTAKA NAKANISHI
1Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Japan;
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  • For correspondence: nakanishi@hyo-med.ac.jp
SEIICHI HIROTA
2Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
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YUDAI HOJO
1Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Japan;
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TATSURO NAKAMURA
1Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Japan;
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TSUTOMU KUMAMOTO
1Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Japan;
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YASUNORI KURAHASHI
1Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Japan;
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YOSHINORI ISHIDA
1Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Japan;
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HISASHI SHINOHARA
1Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Japan;
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Abstract

Background/Aim: Tumor-infiltrating Foxp3+ regulatory T-cells (Ti-Tregs) promote tumor progression and contribute to poor prognosis in gastric cancer, but the relationship between Ti-Tregs and response to chemotherapy for liver metastases from gastric cancer (LMGC) is unclear. We estimated the correlation between pathological response to chemotherapy and Ti-Tregs in LMGC. Patients and Methods: Ti-Tregs were analyzed with immunohistochemistry as CD3+ Foxp3+ cells in patients with synchronous LMGC. Results: Of 53 patients with LMGC, 49 received chemotherapy as initial treatment and 10 underwent R0 resection. LMGC disappeared pathologically in 5 resected cases despite radiologically residual disease. Ti-Tregs were found frequently in residual LMGC and primary lesions but rarely in tumor scar tissue. There was no relationship between frequency of CD8+ cells and pathological response. Conclusion: Marked reduction in Ti-Tregs correlates with pathological complete remission of LMGC. Ti-Tregs may be a biomarker to predict the effects of chemotherapy when used in combination with radiological findings.

Key Words:
  • Liver metastases from gastric cancer
  • tumor-infiltrating Foxp3+ regulatory T-cells
  • pathological response to chemotherapy
  • Received January 13, 2021.
  • Revision received January 24, 2021.
  • Accepted January 25, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (3)
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Pathological Complete Remission of Liver Metastases Correlates With Elimination of Tumor-infiltrating Tregs in Gastric Cancer
YASUTAKA NAKANISHI, SEIICHI HIROTA, YUDAI HOJO, TATSURO NAKAMURA, TSUTOMU KUMAMOTO, YASUNORI KURAHASHI, YOSHINORI ISHIDA, HISASHI SHINOHARA
Anticancer Research Mar 2021, 41 (3) 1571-1577; DOI: 10.21873/anticanres.14917

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Pathological Complete Remission of Liver Metastases Correlates With Elimination of Tumor-infiltrating Tregs in Gastric Cancer
YASUTAKA NAKANISHI, SEIICHI HIROTA, YUDAI HOJO, TATSURO NAKAMURA, TSUTOMU KUMAMOTO, YASUNORI KURAHASHI, YOSHINORI ISHIDA, HISASHI SHINOHARA
Anticancer Research Mar 2021, 41 (3) 1571-1577; DOI: 10.21873/anticanres.14917
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Keywords

  • Liver metastases from gastric cancer
  • tumor-infiltrating Foxp3+ regulatory T-cells
  • pathological response to chemotherapy
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