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Research ArticleClinical Studies

Prognostic Factors and Survival Score for Patients With Anaplastic Thyroid Carcinoma: A Retrospective Study from a Regional Registry

CHARLES MARCHAND-CRETY, MADELINE PASCARD, ADELINE DEBREUVE-THERESETTE, LEILA ETTALHAOUI, CLAIRE SCHVARTZ, MOHAMAD ZALZALI, MATHIAS BRUGEL, SARA BELLEFQIH and STÉPHANIE SERVAGI-VERNAT
Anticancer Research March 2021, 41 (3) 1555-1561; DOI: https://doi.org/10.21873/anticanres.14915
CHARLES MARCHAND-CRETY
1Department of Radiation Therapy, Institut Godinot, Reims, France;
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  • For correspondence: charles.marchandcrety@reims.unicancer.fr charles.marchandcrety@gmail.com
MADELINE PASCARD
2Biostatistics Department, Institut Godinot, Reims, France;
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ADELINE DEBREUVE-THERESETTE
3Thyroid Cancer Registry of Marne-Ardennes, Institut Godinot, Reims, France;
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LEILA ETTALHAOUI
1Department of Radiation Therapy, Institut Godinot, Reims, France;
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CLAIRE SCHVARTZ
4Nuclear Medicine-Thyroid Unit, Institut Godinot, Reims, France;
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MOHAMAD ZALZALI
4Nuclear Medicine-Thyroid Unit, Institut Godinot, Reims, France;
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MATHIAS BRUGEL
5Department of Ambulatory Oncology Care Unit, Hopital Robert Debré, Reims, France
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SARA BELLEFQIH
1Department of Radiation Therapy, Institut Godinot, Reims, France;
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STÉPHANIE SERVAGI-VERNAT
1Department of Radiation Therapy, Institut Godinot, Reims, France;
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Abstract

Background/Aim: Anaplastic thyroid carcinoma (ATC) is the least common but most lethal of thyroid cancer, despite various therapeutic options, with limited efficacy. In order to help therapeutic decision-making, the purpose of this study was to develop a new prognostic score providing survival estimates in patients with ATC. Patients and Methods: Based on a multivariate analysis of 149 retrospectively analyzed patients diagnosed with ATC from 1968 to 2017 at a referral center, a propensity score was developed. A model was generated providing survival probability at 6 months and median overall survival estimates. Results: The median survival was 96 days. The overall survival rate was 35% at 6 months, 20% at 1 year and 13% at 2 years. Stepwise Cox regression revealed that the most appropriate death prediction model included metastatic spread, tumor size and age class as explanatory variables. This model made it possible to define three categories of patients with different survival profiles. Conclusion: Distant metastasis, age and primary tumor size are strong independent factors that affect prognosis in patients with ATC. Using these significant pretreatment factors, we developed a score to predict survival in these patients with poor prognosis.

Key Words:
  • Anaplastic thyroid carcinoma
  • prognosis
  • propensity score
  • survival
  • clinical decision-making
  • Received December 31, 2020.
  • Revision received January 21, 2021.
  • Accepted January 1, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (3)
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Prognostic Factors and Survival Score for Patients With Anaplastic Thyroid Carcinoma: A Retrospective Study from a Regional Registry
CHARLES MARCHAND-CRETY, MADELINE PASCARD, ADELINE DEBREUVE-THERESETTE, LEILA ETTALHAOUI, CLAIRE SCHVARTZ, MOHAMAD ZALZALI, MATHIAS BRUGEL, SARA BELLEFQIH, STÉPHANIE SERVAGI-VERNAT
Anticancer Research Mar 2021, 41 (3) 1555-1561; DOI: 10.21873/anticanres.14915

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Prognostic Factors and Survival Score for Patients With Anaplastic Thyroid Carcinoma: A Retrospective Study from a Regional Registry
CHARLES MARCHAND-CRETY, MADELINE PASCARD, ADELINE DEBREUVE-THERESETTE, LEILA ETTALHAOUI, CLAIRE SCHVARTZ, MOHAMAD ZALZALI, MATHIAS BRUGEL, SARA BELLEFQIH, STÉPHANIE SERVAGI-VERNAT
Anticancer Research Mar 2021, 41 (3) 1555-1561; DOI: 10.21873/anticanres.14915
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Keywords

  • Anaplastic thyroid carcinoma
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  • survival
  • clinical decision-making
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