Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • Log out
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleExperimental Studies

Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue

JAE HWI CHOI, SEE MIN CHOI, SIN WOO LEE, SEONG UK JEH, JAE SEOG HYUN, MIN HO LEE, CHUNWOO LEE, SUNG CHUL KAM, DONG CHUL KIM, JONG SIL LEE and JEONG SEOK HWA
Anticancer Research March 2021, 41 (3) 1377-1386; DOI: https://doi.org/10.21873/anticanres.14895
JAE HWI CHOI
1Department of Urology, Gyeongsang National University Hospital, Jinju, Republic of Korea;
2Department of Urology, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SEE MIN CHOI
1Department of Urology, Gyeongsang National University Hospital, Jinju, Republic of Korea;
2Department of Urology, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea;
3Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SIN WOO LEE
1Department of Urology, Gyeongsang National University Hospital, Jinju, Republic of Korea;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SEONG UK JEH
1Department of Urology, Gyeongsang National University Hospital, Jinju, Republic of Korea;
2Department of Urology, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea;
3Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
JAE SEOG HYUN
1Department of Urology, Gyeongsang National University Hospital, Jinju, Republic of Korea;
2Department of Urology, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea;
3Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MIN HO LEE
4Department of Urology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
CHUNWOO LEE
4Department of Urology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SUNG CHUL KAM
2Department of Urology, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea;
3Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea;
4Department of Urology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DONG CHUL KIM
2Department of Urology, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea;
3Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea;
5Department of Pathology, Gyeongsang National University Hospital, Jinju, Republic of Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
JONG SIL LEE
2Department of Urology, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea;
3Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea;
5Department of Pathology, Gyeongsang National University Hospital, Jinju, Republic of Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
JEONG SEOK HWA
1Department of Urology, Gyeongsang National University Hospital, Jinju, Republic of Korea;
2Department of Urology, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea;
3Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: seogee@gnu.ac.kr
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Background/Aim: The purpose of this study was to examine the expression of estrogen receptor α (ERα) and β (ERβ), androgen receptor (AR), SIRT1, SIRT2 and SIRT3 in prostate cancer (PCa). Materials and Methods: From October 2010 to January 2015, 70 patients who had undergone radical prostatectomy following a PCa diagnosis were enrolled in our study. Normal prostate tissue (NPT) and prostate cancer tissues (PCAT) were separated, and the expression of each receptor in each tissue was analyzed with immunochemical staining. Univariate and multivariate analyses were performed to identify factors affecting the development of PCa. Results: ERβ and AR were highly expressed in PCAT compared with NPT (p<0.05). SIRT2 was highly expressed in NPT and PCAT (p<0.05). Univariate and multivariate analyses showed that AR and SIRT2 affect PCa development. Conclusion: AR is a risk factor for PC, and SIRT2 is associated with a lower incidence of PCa.

Key Words:
  • α estrogen receptor
  • β estrogen receptor
  • the androgen receptor
  • SIRT1
  • SIRT2
  • SIRT3
  • Received October 26, 2020.
  • Revision received January 1, 2021.
  • Accepted January 29, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
View Full Text

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.

patientACCESS

patientACCESS - Patients desiring access to articles
PreviousNext
Back to top

In this issue

Anticancer Research: 41 (3)
Anticancer Research
Vol. 41, Issue 3
March 2021
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
2 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue
JAE HWI CHOI, SEE MIN CHOI, SIN WOO LEE, SEONG UK JEH, JAE SEOG HYUN, MIN HO LEE, CHUNWOO LEE, SUNG CHUL KAM, DONG CHUL KIM, JONG SIL LEE, JEONG SEOK HWA
Anticancer Research Mar 2021, 41 (3) 1377-1386; DOI: 10.21873/anticanres.14895

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue
JAE HWI CHOI, SEE MIN CHOI, SIN WOO LEE, SEONG UK JEH, JAE SEOG HYUN, MIN HO LEE, CHUNWOO LEE, SUNG CHUL KAM, DONG CHUL KIM, JONG SIL LEE, JEONG SEOK HWA
Anticancer Research Mar 2021, 41 (3) 1377-1386; DOI: 10.21873/anticanres.14895
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • TIG1 Inhibits the mTOR Signaling Pathway in Malignant Melanoma Through the VAC14 Protein
  • Novel α-Trifluoromethyl Chalcone Exerts Antitumor Effects Against Prostate Cancer Cells
  • Differential Effects of Anti-PD-1/PD-L1 Checkpoint Inhibitors on Adhesion Molecules and Cytokine Secretion by THP-1 Monocytes
Show more Experimental Studies

Similar Articles

Keywords

  • α estrogen receptor
  • β estrogen receptor
  • the androgen receptor
  • SIRT1
  • SIRT2
  • SIRT3
Anticancer Research

© 2023 Anticancer Research

Powered by HighWire