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Research ArticleExperimental Studies

Cancer-derived Exosomes Activate Immune Surveillance and Suppress Peritoneal Metastasis of Murine Colonic Cancer

AYA TOKUDA, TORU MIYAKE, DAIKI YASUKAWA, DAIJI IKUTA, KEN-ICHI MUKAISHO, SATOSHI MURATA, TOMOHARU SHIMIZU and MASAJI TANI
Anticancer Research March 2021, 41 (3) 1327-1339; DOI: https://doi.org/10.21873/anticanres.14890
AYA TOKUDA
1Department of Surgery, Shiga University of Medical Science, Shiga, Japan;
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TORU MIYAKE
1Department of Surgery, Shiga University of Medical Science, Shiga, Japan;
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  • For correspondence: myk@belle.shiga-med.ac.jp
DAIKI YASUKAWA
1Department of Surgery, Shiga University of Medical Science, Shiga, Japan;
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DAIJI IKUTA
1Department of Surgery, Shiga University of Medical Science, Shiga, Japan;
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KEN-ICHI MUKAISHO
2Department of Molecular and Diagnostic Pathology, Shiga University of Medical Science, Shiga, Japan
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SATOSHI MURATA
1Department of Surgery, Shiga University of Medical Science, Shiga, Japan;
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TOMOHARU SHIMIZU
1Department of Surgery, Shiga University of Medical Science, Shiga, Japan;
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MASAJI TANI
1Department of Surgery, Shiga University of Medical Science, Shiga, Japan;
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Abstract

Background: Colonic cancer is associated with a low incidence of peritoneal metastasis compared with gastric cancer; however, the reason for this remains unclear. In this study, a model of peritoneal dissemination using the CT26 murine colon cancer cell line was used to analyze the physiological roles of cancer-derived exosomes. Materials and Methods: Exosomes were collected from the supernatant of CT26 cell culture by ultracentrifugation. The number of peritoneal disseminations in two mouse models of colonic cancer pre-administered exosomes or phosphate-buffered saline were compared. Results: Cancer-derived exosomes suppressed peritoneal dissemination compared to phosphate-buffered saline. After administration of exosomes, the number of intraperitoneal macrophages and the expression of inducible nitric oxide synthase increased. Furthermore, cancer-derived exosomes increased activated natural killer cells and interferon-γ expression. Conclusion: Tumor-derived exosomes from colonic cancer may suppress peritoneal metastasis via an immunological mechanism.

Key Words:
  • Colorectal cancer
  • exosome
  • inducible nitric oxide synthase
  • macrophage
  • peritoneal metastasis
  • Received January 7, 2021.
  • Revision received February 2, 2021.
  • Accepted February 3, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (3)
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Cancer-derived Exosomes Activate Immune Surveillance and Suppress Peritoneal Metastasis of Murine Colonic Cancer
AYA TOKUDA, TORU MIYAKE, DAIKI YASUKAWA, DAIJI IKUTA, KEN-ICHI MUKAISHO, SATOSHI MURATA, TOMOHARU SHIMIZU, MASAJI TANI
Anticancer Research Mar 2021, 41 (3) 1327-1339; DOI: 10.21873/anticanres.14890

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Cancer-derived Exosomes Activate Immune Surveillance and Suppress Peritoneal Metastasis of Murine Colonic Cancer
AYA TOKUDA, TORU MIYAKE, DAIKI YASUKAWA, DAIJI IKUTA, KEN-ICHI MUKAISHO, SATOSHI MURATA, TOMOHARU SHIMIZU, MASAJI TANI
Anticancer Research Mar 2021, 41 (3) 1327-1339; DOI: 10.21873/anticanres.14890
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Keywords

  • colorectal cancer
  • exosome
  • inducible nitric oxide synthase
  • macrophage
  • peritoneal metastasis
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