Anticancer Research: 41 (3)

March 2021; Volume 41,Issue 3

Reviews

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T-cell-based Immunotherapies for Haematological Cancers, Part A: A SWOT Analysis of Immune Checkpoint Inhibitors (ICIs) and Bispecific T-Cell Engagers (BiTEs)
KATHRINE S. RALLIS, CHRISTOPHER R.T. HILLYAR, MICHAIL SIDERIS and JEFF K. DAVIES

Anticancer Research March 2021, 41 (3) 1123-1141; DOI: https://doi.org/10.21873/anticanres.14870
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T-cell-based Immunotherapies for Haematological Cancers, Part B: A SWOT Analysis of Adoptive Cell Therapies
KATHRINE S. RALLIS, CHRISTOPHER R.T. HILLYAR, MICHAIL SIDERIS and JEFF K. DAVIES

Anticancer Research March 2021, 41 (3) 1143-1156; DOI: https://doi.org/10.21873/anticanres.14871
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Tonsillectomy as a Prevention Strategy in the Light of Increasing Incidence of Oropharyngeal Cancer – a Research of Current Literature
ACHIM M. FRANZEN and JOCHEN P. WINDFUHR

Anticancer Research March 2021, 41 (3) 1157-1161; DOI: https://doi.org/10.21873/anticanres.14872
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Pre-treatment Apparent Diffusion Coefficient Does Not Predict Therapy Response to Radiochemotherapy in Cervical Cancer: A Systematic Review and Meta-analysis
HANS-JONAS MEYER, ANDREAS WIENKE and ALEXEY SUROV

Anticancer Research March 2021, 41 (3) 1163-1170; DOI: https://doi.org/10.21873/anticanres.14873

Experimental Studies

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Biological Activity of a Thiobarbituric Acid Compound in Neuroblastomas
SANG Y. LEE, BECKY SLAGLE-WEBB, ARUN K. SHARMA and JAMES R. CONNOR

Anticancer Research March 2021, 41 (3) 1171-1181; DOI: https://doi.org/10.21873/anticanres.14874
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Understanding the Biological Basis of Glioblastoma Patient-derived Spheroids
KAROLÍNA TURNOVCOVA, DANA MAREKOVA, TOLGA SURSAL, MARKETA KRUPOVA, RONAN GANDHI, PETR KRUPA, RADEK KAISER, VIT HERYNEK, DAVID NETUKA, PAVLA JENDELOVA and MEENA JHANWAR-UNIYAL

Anticancer Research March 2021, 41 (3) 1183-1195; DOI: https://doi.org/10.21873/anticanres.14875
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Autophagy Induction by α-Santalol in Human Prostate Cancer Cells
COLE WALTERS, MAVERICK REED, SAMANTHA BARTHOLOMEW and AJAY BOMMAREDDY

Anticancer Research March 2021, 41 (3) 1197-1202; DOI: https://doi.org/10.21873/anticanres.14876
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The Expression of PEDF and its Putative Receptors in Hepatocellular Carcinoma and Background Liver Tissue
JUN AKIBA, TAKAFUMI YOSHIDA, EIJI SADASHIMA, KAZUYA MURATA, TAKANORI MATSUI, SHO-ICHI YAMAGISHI, HIRONORI KUSANO, YUTARO MIHARA, SHINJI MIZUOCHI, YOSHINAO KINJOU, YOSHIKI NAITO, TORU HISAKA, HISAMUNE SAKAI, KOJI OKUDA, OSAMU NAKASHIMA and HIROHISA YANO

Anticancer Research March 2021, 41 (3) 1203-1212; DOI: https://doi.org/10.21873/anticanres.14877
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The Anti-oxidant Monoterpene p-Cymene Reduced the Occurrence of Colorectal Cancer in a Hyperlipidemia Rat Model by Reducing Oxidative Stress and Expression of Inflammatory Cytokines
SHUIMING WANG, XIAOFENG WANG, YU WANG, QIANG LENG, YU SUN, ROBERT M. HOFFMAN and HEIYING JIN

Anticancer Research March 2021, 41 (3) 1213-1218; DOI: https://doi.org/10.21873/anticanres.14878
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CD105 (Endoglin): A Potential Anticancer Therapeutic Inhibits Mitogenesis and Map Kinase Pathway Activation
DONGHUI LIU, SHANT KUMAR, JASON ASHWORTH, KAMELA ALI, ABDULMANNAN FADEL, BAOQIANG GUO and MARK SLEVIN

Anticancer Research March 2021, 41 (3) 1219-1229; DOI: https://doi.org/10.21873/anticanres.14879
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CD73 Is Regulated by the EGFR-ERK Signaling Pathway in Non-small Cell Lung Cancer
SEBASTIAN GRIESING, BIN-CHI LIAO and JAMES CHIH-HSIN YANG

Anticancer Research March 2021, 41 (3) 1231-1242; DOI: https://doi.org/10.21873/anticanres.14880
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The Impact of Insulin on Low-dose Metronomic Vinorelbine and Mafosfamide in Breast Cancer Cells
SLAVOMIR KRAJNAK, AMELIE LOEWE, MARCO JOHANNES BATTISTA, ANNETTE HASENBURG, ANNE-SOPHIE HEIMES, MARCUS SCHMIDT, ROXANA SCHWAB and WALBURGIS BRENNER

Anticancer Research March 2021, 41 (3) 1243-1250; DOI: https://doi.org/10.21873/anticanres.14881
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Sorafenib Induces Apoptosis and Inhibits NF-κB-mediated Anti-apoptotic and Metastatic Potential in Osteosarcoma Cells
CHING-HSUAN WU, KUNG-HUNG LIN, BO-SIANG FU, FEI-TING HSU, JAI-JEN TSAI, MAO-CHI WENG and PO-JUNG PAN

Anticancer Research March 2021, 41 (3) 1251-1259; DOI: https://doi.org/10.21873/anticanres.14882
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Erlotinib Activates Different Cell Death Pathways in EGFR-mutant Lung Cancer Cells Grown in 3D Versus 2D Culture Systems
HYUN-KYUNG LEE, MIN HYE NOH, SEUNG-WOO HONG, SEUNG-MI KIM, SUNG HYUN KIM, YEONG SEOK KIM, V. COURTNEY BROADDUS and DAE YOUNG HUR

Anticancer Research March 2021, 41 (3) 1261-1269; DOI: https://doi.org/10.21873/anticanres.14883
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Synergistic Effect of Apigenin and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa Cells
SERA KAYACAN, KAAN YILANCIOGLU, AYSE SEDA AKDEMIR, FATMA KAYA-DAGISTANLI, GULAY MELIKOGLU and MELEK OZTURK

Anticancer Research March 2021, 41 (3) 1271-1282; DOI: https://doi.org/10.21873/anticanres.14884
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Inhibition of Heat-shock Protein 27 Reduces 5-Fluorouracil-acquired Resistance in Human Colon Cancer Cells
YUSUKE ASADA, MASASHI TSURUTA, KOJI OKABAYASHI, KOHEI SHIGETA, TAKASHI ISHIDA, TAKEHIRO SHIMADA, HIROFUMI SUZUMURA, KAORU KOISHIKAWA, SHINGO AKIMOTO, HIROTOSHI HASEGAWA and YUKO KITAGAWA

Anticancer Research March 2021, 41 (3) 1283-1290; DOI: https://doi.org/10.21873/anticanres.14885
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Tumor Cell Microenvironment and Microvessel Density Analysis in MALT Type Lymphoma
ROBERTO TAMMA, GIUSEPPE INGRAVALLO, TIZIANA ANNESE, MICHELA DE GIORGIS, FABRIZIA DI GIOVANNI, FRANCESCO GAUDIO, TOMMASINA PERRONE, PELLEGRINO MUSTO, GIORGINA SPECCHIA and DOMENICO RIBATTI

Anticancer Research March 2021, 41 (3) 1291-1297; DOI: https://doi.org/10.21873/anticanres.14886
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Fucoxanthin Prevents Colorectal Cancer Development in Dextran Sodium Sulfate-treated Apc^Min/+ Mice
MASARU TERASAKI, TAKAHIRO HAMOYA, ATSUHITO KUBOTA, HIROYUKI KOJIMA, TAKUJI TANAKA, HAYATO MAEDA, KAZUO MIYASHITA and MICHIHIRO MUTOH

Anticancer Research March 2021, 41 (3) 1299-1305; DOI: https://doi.org/10.21873/anticanres.14887
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Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis
YUKA SASAKI, HIROSHI KUWATA, ERI AIDA, TSUBASA OCHIAI, DAISUKE KAMEI, YOSHIHITO NAKATANI and SHUNTARO HARA

Anticancer Research March 2021, 41 (3) 1307-1314; DOI: https://doi.org/10.21873/anticanres.14888
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Targeting CALM2 Inhibits Hepatocellular Carcinoma Growth and Metastasis by Suppressing E2F5-mediated Cell Cycle Progression
SO-YOUNG PARK, YU-RI SEO, MIN JI KO, JAE-HO LEE, KYUNG-SOO CHUN, MIN-JI KIM, YOUNG-KUG CHOO, TAE-JIN LEE and YUN-HAN LEE

Anticancer Research March 2021, 41 (3) 1315-1325; DOI: https://doi.org/10.21873/anticanres.14889
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Cancer-derived Exosomes Activate Immune Surveillance and Suppress Peritoneal Metastasis of Murine Colonic Cancer
AYA TOKUDA, TORU MIYAKE, DAIKI YASUKAWA, DAIJI IKUTA, KEN-ICHI MUKAISHO, SATOSHI MURATA, TOMOHARU SHIMIZU and MASAJI TANI

Anticancer Research March 2021, 41 (3) 1327-1339; DOI: https://doi.org/10.21873/anticanres.14890
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Robustness of a Cancer Profiling Test Using Formalin-fixed Paraffin Embedded Tumor Specimens
SHIN ITO, IKURO SATO, MAI MOCHIZUKI, KAZUNORI YAMAGUCHI, KEIICHI TAMAI, TAKAMICHI MINATO, NOBUHIRO TANUMA, HIROSHI SHIMA and JUN YASUDA

Anticancer Research March 2021, 41 (3) 1341-1348; DOI: https://doi.org/10.21873/anticanres.14891
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Annexin A10 Expression Is Associated With Poor Prognosis in Small Bowel Adenocarcinoma
AKIRA ISHIKAWA, KAZUYA KURAOKA, JUNICHI ZAITSU, AKIHISA SAITO, TOSHIO KUWAI, YOSUKE SHIMIZU, TAKESHI SUDO, HIROTAKA TASHIRO, KIYOMI TANIYAMA and WATARU YASUI

Anticancer Research March 2021, 41 (3) 1349-1355; DOI: https://doi.org/10.21873/anticanres.14892
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Amentoflavone Induces Cell-cycle Arrest, Apoptosis, and Invasion Inhibition in Non-small Cell Lung Cancer Cells
WEI-TING CHEN, CHENG-HSIEN CHEN, HUNG-TAI SU, PO-FU YUEH, FEI-TING HSU and I-TSANG CHIANG

Anticancer Research March 2021, 41 (3) 1357-1364; DOI: https://doi.org/10.21873/anticanres.14893
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Calorie Restriction Suppresses the Progression of Radiation-Induced Intestinal Tumours in C3B6F1 Apc^Min/+ Mice
TAKAMITSU MORIOKA, SHUNSUKE YAMAZAKI, HIROMI YANAGIHARA, MASAAKI SUNAOSHI, MUTSUMI KAMINISHI and SHIZUKO KAKINUMA

Anticancer Research March 2021, 41 (3) 1365-1375; DOI: https://doi.org/10.21873/anticanres.14894
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Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue
JAE HWI CHOI, SEE MIN CHOI, SIN WOO LEE, SEONG UK JEH, JAE SEOG HYUN, MIN HO LEE, CHUNWOO LEE, SUNG CHUL KAM, DONG CHUL KIM, JONG SIL LEE and JEONG SEOK HWA

Anticancer Research March 2021, 41 (3) 1377-1386; DOI: https://doi.org/10.21873/anticanres.14895
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Effect of Metformin in Combination With Trametinib and Paclitaxel on Cell Survival and Metastasis in Melanoma Cells
YOUNGKI LEE and DEOKBAE PARK

Anticancer Research March 2021, 41 (3) 1387-1399; DOI: https://doi.org/10.21873/anticanres.14896
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Establishment and Characterization of a New Pancreatic Ductal Adenocarcinoma Cell Line Capan-26
EGLE ZALYTE, VERONIKA DEDONYTE, BENEDIKTAS KURLINKUS, AUDRIUS SILEIKIS, PETER SCHEMMER and MINDAUGAS VALIUS

Anticancer Research March 2021, 41 (3) 1401-1406; DOI: https://doi.org/10.21873/anticanres.14897
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470 nm LED Irradiation Inhibits the Invasiveness of CD133-positive Human Colorectal Cancer Stem Cells by Suppressing the Cyclooxygenase-2/prostaglandin E2 Pathway
SANGJOON MO, HYUN JEONG KU, SUN-HYANG CHOI, HYE JUNG JEONG, DONG-GUK PARK, MAN HWAN OH and JIN CHUL AHN

Anticancer Research March 2021, 41 (3) 1407-1420; DOI: https://doi.org/10.21873/anticanres.14898
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The Clinical Utility of Serum CXCR-2 Assessment in Colorectal Cancer (CRC) Patients
SARA PĄCZEK, MARTA ŁUKASZEWICZ-ZAJĄC, MARIUSZ GRYKO, AGNIESZKA KULCZYŃSKA-PRZYBIK and BARBARA MROCZKO

Anticancer Research March 2021, 41 (3) 1421-1428; DOI: https://doi.org/10.21873/anticanres.14899
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Bioreductive Activation of Antitumour Drugs, Doxorubicin and Pirarubicin, Does Not Affect Their Ability to Induce Apoptosis of Sensitive and Multidrug Resistant Leukaemia HL60 Cells
DOROTA KOSTRZEWA-NOWAK and JOLANTA TARASIUK

Anticancer Research March 2021, 41 (3) 1429-1438; DOI: https://doi.org/10.21873/anticanres.14900

Clinical Studies

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Hearing Status of Children and Adolescents With Familial Adenomatous Polyposis
URSULA M. FINDLEN, REBECCA L. BELT, LING FAN, NIKIA BRIDGES, JASON A. BENEDICT and STEVEN H. ERDMAN

Anticancer Research March 2021, 41 (3) 1439-1444; DOI: https://doi.org/10.21873/anticanres.14901
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Staged Stereotactic Radiosurgery Decreases Symptomatic Radionecrosis in Large Brain Metastasis
NEIL CHEVLI, HUI-CHUAN WANG, PRACHI DUBEY, WAQAR HAQUE, ANDREW M. FARACH, RAMIRO PINO, ROBERT C. ROSTOMILY, E. BRIAN BUTLER and BIN S. TEH

Anticancer Research March 2021, 41 (3) 1445-1449; DOI: https://doi.org/10.21873/anticanres.14902
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Differences Between CT-Perfusion and Biphasic Contrast-enhanced CT for Detection and Characterization of Hepatocellular Carcinoma: Potential Explanations for Discrepant Cases
REGINE MARIETTE PERL, JOHANNES PORTUGALL, CLEMENS HINTERLEITNER, MARTINA HINTERLEITNER, CHRISTOPHER KLOTH, SVEN STEPHAN WALTER, MICHAEL BITZER and MARIUS STEFAN HORGER

Anticancer Research March 2021, 41 (3) 1451-1458; DOI: https://doi.org/10.21873/anticanres.14903
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A Diagnostic Score (DS) Is a Powerful Tool in Diagnosis of Acute Appendicitis in Elderly Patients With Acute Abdominal Pain
MAARET ESKELINEN, JANNICA MEKLIN, KARI SYRJÄNEN and MATTI ESKELINEN

Anticancer Research March 2021, 41 (3) 1459-1469; DOI: https://doi.org/10.21873/anticanres.14904
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Independent Validation of a Comprehensive Machine Learning Approach Predicting Survival After Radiotherapy for Bone Metastases
CARSTEN NIEDER, BÅRD MANNSÅKER and ROSALBA YOBUTA

Anticancer Research March 2021, 41 (3) 1471-1474; DOI: https://doi.org/10.21873/anticanres.14905
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MDM4 as a Prognostic Factor for Patients With Gastric Cancer With Low Expression of p53
XIAOCHEN ZHANG, YOSHIYUKI YAMAMOTO, XIAOXUAN WANG, MASASHI SATO, MAMIKO IMANISHI, AKINORI SUGAYA, MITSUAKI HIROSE, SHINJI ENDO, TOSHIKAZU MORIWAKI, KENJI YAMATO and ICHINOSUKE HYODO

Anticancer Research March 2021, 41 (3) 1475-1483; DOI: https://doi.org/10.21873/anticanres.14906
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Clinical Trial of a Cancer Vaccine Targeting VEGF and KIF20A in Advanced Biliary Tract Cancer
MUTSUNORI MURAHASHI, TOSHIHISA TSURUTA, KAZUNARI YAMADA, YASUKI HIJIKATA, HISANOBU OGATA, JUNJI KISHIMOTO, SACHIKO YOSHIMURA, TETSURO HIKICHI, YOICHI NAKANISHI and KENZABURO TANI

Anticancer Research March 2021, 41 (3) 1485-1496; DOI: https://doi.org/10.21873/anticanres.14907
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Autoantibody Positivity Is a Risk Factor for Chemotherapy-induced Exacerbation of Interstitial Pneumonia in Lung Cancer
NORIAKI ITO, TAKESHI MASUDA, TAKU NAKASHIMA, SATOSHI NAKAO, KAKUHIRO YAMAGUCHI, SHINJIRO SAKAMOTO, YASUSHI HORIMASU, SHINTARO MIYAMOTO, HIROSHI IWAMOTO, KAZUNORI FUJITAKA, HIRONOBU HAMADA and NOBORU HATTORI

Anticancer Research March 2021, 41 (3) 1497-1506; DOI: https://doi.org/10.21873/anticanres.14908
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Resistance to Preoperative Oral Care Is Associated With Postoperative Pneumonia After Oesophageal Cancer Surgery
KENGO KURIYAMA, MAKOTO SOHDA, TAKAYOSHI WATANABE, HIDEYUKI SAITO, TOMONORI YOSHIDA, KEIGO HARA, MAKOTO SAKAI, MAI KIM, TAKUYA ASAMI, SATOSHI YOKOO, HIROYUKI KUWANO, KEN SHIRABE and HIROSHI SAEKI

Anticancer Research March 2021, 41 (3) 1507-1514; DOI: https://doi.org/10.21873/anticanres.14909
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Nondysplastic Crypts in Fission in Nonpolypoid Adenomas and in the Adjacent Mucosa Support Field Cancerization in the Colon
CARLOS A. RUBIO and PETER T. SCHMIDT

Anticancer Research March 2021, 41 (3) 1515-1521; DOI: https://doi.org/10.21873/anticanres.14910
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Risk Factors for Venous Thromboembolism in Patients With Small Cell Lung Cancer
EVANGELOS DIMAKAKOS, KONSTANTINOS LIVANIOS, IOANNIS VATHIOTIS, GEORGIA GOMATOU, IOANNIS GKIOZOS, ELIAS KOTTEAS, ELIAS KAINIS and KONSTANTINOS SYRIGOS

Anticancer Research March 2021, 41 (3) 1523-1528; DOI: https://doi.org/10.21873/anticanres.14911
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Anatomical Predictors of Dosimetric Advantages for Deep-inspiration-breath-hold 3D-conformal Radiotherapy Among Women With Left Breast Cancer
GIANLUCA FERINI, LAURA MOLINO, ANTONELLA TRIPOLI, VITO VALENTI, SALVATORE IVAN ILLARI, VALENTINA ANNA MARCHESE, IRENE RITA CRAVAGNO and GIUSEPPINA RITA BORZI

Anticancer Research March 2021, 41 (3) 1529-1538; DOI: https://doi.org/10.21873/anticanres.14912
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Site-specific Response to Nivolumab in Renal Cell Carcinoma
TAKAHITO NEGISHI, NOBUKI FURUBAYASHI, TOHRU NAKAGAWA, NAOTAKA NISHIYAMA, HIROSHI KITAMURA, YOSHIFUMI HORI, KENTAROU KUROIWA, YUHYON SON, NARIHITO SEKI, TOSHIHISA TOMODA, EIJIRO OKAJIMA and MOTONOBU NAKAMURA

Anticancer Research March 2021, 41 (3) 1539-1545; DOI: https://doi.org/10.21873/anticanres.14913
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Risk Factors for Totally Implantable Central Venous Access Port-related Infection in Patients With Malignancy
SATORU FURUHASHI, YOSHIFUMI MORITA, SHINYA IDA, RYUTA MURAKI, RYO KITAJIMA, KATSUNORI SUZUKI, MAKOTO TAKEDA, HIROTOSHI KIKUCHI, YOSHIHIRO HIRAMATSU, KIYOTAKA KURACHI, YOJI SHIDO, KEN SUGIMOTO, HIROAKI ITO, YUICHIRO MAEKAWA, HIROYUKI MINETA, HIDEAKI MIYAKE and HIROYA TAKEUCHI

Anticancer Research March 2021, 41 (3) 1547-1553; DOI: https://doi.org/10.21873/anticanres.14914
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Prognostic Factors and Survival Score for Patients With Anaplastic Thyroid Carcinoma: A Retrospective Study from a Regional Registry
CHARLES MARCHAND-CRETY, MADELINE PASCARD, ADELINE DEBREUVE-THERESETTE, LEILA ETTALHAOUI, CLAIRE SCHVARTZ, MOHAMAD ZALZALI, MATHIAS BRUGEL, SARA BELLEFQIH and STÉPHANIE SERVAGI-VERNAT

Anticancer Research March 2021, 41 (3) 1555-1561; DOI: https://doi.org/10.21873/anticanres.14915
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NQO1 as a Marker of Chemosensitivity and Prognosis for Colorectal Liver Metastasis
YUKI HIROSE, JUN SAKATA, TAKASHI KOBAYASHI, KOHEI MIURA, KIZUKI YUZA, MAE NAKANO, HIROSHI ICHIKAWA, MASAYUKI NAGAHASHI, YOSHIFUMI SHIMADA, HITOSHI KAMEYAMA and TOSHIFUMI WAKAI

Anticancer Research March 2021, 41 (3) 1563-1570; DOI: https://doi.org/10.21873/anticanres.14916
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Pathological Complete Remission of Liver Metastases Correlates With Elimination of Tumor-infiltrating Tregs in Gastric Cancer
YASUTAKA NAKANISHI, SEIICHI HIROTA, YUDAI HOJO, TATSURO NAKAMURA, TSUTOMU KUMAMOTO, YASUNORI KURAHASHI, YOSHINORI ISHIDA and HISASHI SHINOHARA

Anticancer Research March 2021, 41 (3) 1571-1577; DOI: https://doi.org/10.21873/anticanres.14917
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Prominent Papillary Growth Pattern and Severe Nuclear Pleomorphism Induced by Neoadjuvant Chemotherapy in Ovarian Mucinous Carcinoma: Potential for Misdiagnosis as High-grade Serous Carcinoma
HEE JUNG KWON, SANG YONG SONG and HYUN-SOO KIM

Anticancer Research March 2021, 41 (3) 1579-1586; DOI: https://doi.org/10.21873/anticanres.14918
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Radiotherapy as Part of Treatment Strategies in Nasal Cavity and Paranasal Sinus Malignancies
NORA OWIN, KHALED ELSAYAD, DANIEL ROLF, UWE HAVERKAMP, DOMINIK SUWELACK, ROBERT TSCHAKERT, HENDRIK BERSSENBRUGGE, JOHANNES KLEINHEINZ, CLAUDIA RUDACK and HANS THEODOR EICH

Anticancer Research March 2021, 41 (3) 1587-1592; DOI: https://doi.org/10.21873/anticanres.14919
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A High Postoperative Serum C-reactive Protein Level Has a Negative Impact on Long-term Survival, Regardless of Postoperative Infectious Complications, in Patients Who Undergo Laparoscopic Surgery for Colorectal Cancer
MASATSUNE SHIBUTANI, WANG EN, YUKI OKAZAKI, KIYOSHI MAEDA, KOSEI HIRAKAWA and MASAICHI OHIRA

Anticancer Research March 2021, 41 (3) 1593-1598; DOI: https://doi.org/10.21873/anticanres.14920
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Blood Cell Count Biomarkers Predicting Efficacy of Pembrolizumab as Second-line Therapy for Advanced Urothelial Carcinoma
YOSHIFUMI KADONO, SHOHEI KAWAGUCHI, TAKAHIRO NOHARA, KAZUYOSHI SHIGEHARA, KOUJI IZUMI, TAIKI KAMIJIMA, CHIKASHI SETO, AKINOBU TAKANO, SATOSHI YOTSUYANAGI, RYUNOSUKE NAKAGAWA, TOHRU MIYAGI, SHUHEI AOYAMA, HIDEKI ASAHI, RIE FUKUDA and ATSUSHI MIZOKAMI

Anticancer Research March 2021, 41 (3) 1599-1606; DOI: https://doi.org/10.21873/anticanres.14921
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Predictive Impact of Prognostic Nutritional Index on Pembrolizumab for Metastatic Urothelial Carcinoma Resistant to Platinum-based Chemotherapy
YUDAI ISHIYAMA, TSUNENORI KONDO, YUKI NEMOTO, YUKI KOBARI, HIROKI ISHIHARA, HIDEKAZU TACHIBANA, KAZUHIKO YOSHIDA, YASUNOBU HASHIMOTO, TOSHIO TAKAGI, JUNPEI IIZUKA and KAZUNARI TANABE

Anticancer Research March 2021, 41 (3) 1607-1614; DOI: https://doi.org/10.21873/anticanres.14922
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Primary Prophylaxis of Febrile Neutropenia With Pegfilgrastim in Small-cell Lung Cancer Patients Receiving Amrubicin as Second-line Therapy
YUKINA SATO, HIROTOSHI IIHARA, MOTOHIKO KINOMURA, CHIEMI HIROSE, HIRONORI FUJII, JUNKI ENDO, KOMEI YANASE, DAIZO KAITO, YUKA SASAKI, TAKENOBU GOMYO, CHIZURU SAKAI, MASAMICHI IWAI, YOSHIKI TSUBOI, TAKUMA ISHIHARA, RYO KOBAYASHI, YASUSHI OHNO and AKIO SUZUKI

Anticancer Research March 2021, 41 (3) 1615-1620; DOI: https://doi.org/10.21873/anticanres.14923
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Prognostic Impact of Albumin-bilirubin (ALBI) Grade on Non-small Lung Cell Carcinoma: A Propensity-score Matched Analysis
FUMIHIKO KINOSHITA, TAKANORI YAMASHITA, YUKA OKU, KEISUKE KOSAI, YUKI ONO, SHO WAKASU, NAOKI HARATAKE, GOUJI TOYOKAWA, TOMOYOSHI TAKENAKA, TETSUZO TAGAWA, MOTOTSUGU SHIMOKAWA, NAOKI NAKASHIMA and MASAKI MORI

Anticancer Research March 2021, 41 (3) 1621-1628; DOI: https://doi.org/10.21873/anticanres.14924
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Efficacy of Adjuvant Chemotherapy According to the Pathological Response to Neoadjuvant Chemotherapy Among Patients With Pancreatic Ductal Adenocarcinoma
SHOZO MORI, TAKU AOKI, YUHKI SAKURAOKA, TAKAYUKI SHIMIZU, TAKAMUNE YAMAGUCHI, KYUNG-HWA PARK, TAKATSUGU MATSUMOTO, TAKAYUKI SHIRAKI, YUKIHIRO ISO and KEIICHI KUBOTA

Anticancer Research March 2021, 41 (3) 1629-1639; DOI: https://doi.org/10.21873/anticanres.14925
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Acute Kidney Injury Following Hyperthermic Intraperitoneal Chemotherapy With Cisplatin
KERRY L. CHEN, RAPHAEL SHAMAVONIAN, JOSH B. KARPES, NAYEF A. ALZAHRANI and DAVID L. MORRIS

Anticancer Research March 2021, 41 (3) 1641-1646; DOI: https://doi.org/10.21873/anticanres.14926
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Up-regulation of HDAC6 Results in Poor Prognosis and Chemoresistance in Patients With Advanced Ovarian High-grade Serous Carcinoma
MITSUTAKE YANO, MARIKO MIYAZAWA, NAOKI OGANE, AIKO OGASAWARA, KOSEI HASEGAWA, HISASHI NARAHARA and MASANORI YASUDA

Anticancer Research March 2021, 41 (3) 1647-1654; DOI: https://doi.org/10.21873/anticanres.14927
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Extracellular Water-to-total Body Water Ratio as an Objective Biomarker for Frailty in Lung Cancer Patients
TOMONORI HIRASHIMA, YOSHIMI NODA, HIDEKAZU SUZUKI, SHINGO NASU, AYAKO TANAKA, NAOKO MORISHITA, NORIKO RYOTA, KAORI IWATA, YUKARI OKADA and NORIO OKAMOTO

Anticancer Research March 2021, 41 (3) 1655-1662; DOI: https://doi.org/10.21873/anticanres.14928
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Neutrophil-to-lymphocyte Ratio as a Predictor of Malignancy of Intraductal Papillary Mucinous Neoplasms
KEISHI SUGIMACHI, YOHEI MANO, YOSHIHIRO MATSUMOTO, TOMONORI NAKANOKO, HIDEO UEHARA, YUICHIRO NAKASHIMA, MASAHIKO SUGIYAMA, MITSUHIKO OTA, MASARU MORITA and YASUSHI TOH

Anticancer Research March 2021, 41 (3) 1663-1669; DOI: https://doi.org/10.21873/anticanres.14929
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First-line Gemcitabine Versus Treatment of Physician’s Choice for Metastatic Breast Cancer: A Prospective Cohort Study
SHINYA YAMAMOTO, KAZUTAKA NARUI, TAKASHI ISHIKAWA, SHOKO ADACHI, KAZUHIRO SHIMADA, DAISUKE SHIMIZU, AKIMITSU YAMADA, SADATOSHI SUGAE, MIKIKO TANABE, MARI OBA, SATOSHI MORITA, TAKAKO DOI, SATOSHI HASEGAWA, TOMOYUKI MORITA, AYAKO KITO, TAKASHI CHISHIMA, YASUSHI ICHIKAWA and ITARU ENDO

Anticancer Research March 2021, 41 (3) 1671-1676; DOI: https://doi.org/10.21873/anticanres.14930
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Feasibility and Safety of Lateral Pelvic Lymph Node Dissection After Neoadjuvant Chemoradiotherapy for Elderly Patients With Locally Advanced Rectal Cancer
KYOSUKE AGAWA, TAKERU MATSUDA, KIMIHIRO YAMASHITA, HIROSHI HASEGAWA, GOSUKE TAKIGUCHI, NAOKI URAKAWA, SHINGO KANAJI, TARO OSHIKIRI, TETSU NAKAMURA, SATOSHI SUZUKI and YOSHIHIRO KAKEJI

Anticancer Research March 2021, 41 (3) 1677-1682; DOI: https://doi.org/10.21873/anticanres.14931
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Baseline Tumour Size as a Prognostic Factor for Radioiodine-refractory Differentiated Thyroid Cancer Treated With Lenvatinib
NAOKI FUKUDA, KAZUHISA TODA, AKIHIRO OHMOTO, XIAOFEI WANG, NAOMI HAYASHI, TETSUYA URASAKI, YASUYOSHI SATO, KENJI NAKANO, MAKIKO ONO, JUNICHI TOMOMATSU, HIROKI MITANI and SHUNJI TAKAHASHI

Anticancer Research March 2021, 41 (3) 1683-1691; DOI: https://doi.org/10.21873/anticanres.14932
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Complete Response of Bone Metastasis in Non-small Cell Lung Cancer With Pembrolizumab: Two Case Reports
YOHEI ASANO, NORIO YAMAMOTO, KATSUHIRO HAYASHI, AKIHIKO TAKEUCHI, SHINJI MIWA, KENTARO IGARASHI, HIROTAKA YONEZAWA, YOSHIHIRO ARAKI, SEI MORINAGA, KAZUO KASAHARA, TAKASHI SONE and HIROYUKI TSUCHIYA

Anticancer Research March 2021, 41 (3) 1693-1699; DOI: https://doi.org/10.21873/anticanres.14933
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Impact of the Regional Palliative Care Pathway on Emergency Room Visits and Hospitalizations
OLLI HALTIA, OUTI M. HIRVONEN, TIINA SAARTO and JUHO T. LEHTO

Anticancer Research March 2021, 41 (3) 1701-1706; DOI: https://doi.org/10.21873/anticanres.14934
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Drug-induced Interstitial Lung Disease Has the Same Degree of Risk for Mortality as Old Age in Patients With Lung Cancer
KOHEI IWASHITA, TOMOHIRO MIZUNO, SATOMI KUMAZAWA, KAZUYOSHI IMAIZUMI and SHIGEKI YAMADA

Anticancer Research March 2021, 41 (3) 1707-1711; DOI: https://doi.org/10.21873/anticanres.14935

Erratum

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Erratum
Anticancer Research March 2021, 41 (3) 1713; DOI: https://doi.org/10.21873/anticanres.41.3.1713

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