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Research ArticleExperimental Studies

YYB-101, a Humanized Antihepatocyte Growth Factor Monoclonal Antibody, Inhibits Ovarian Cancer Cell Motility and Proliferation

HYUN JUNG KIM and KYUN HEO
Anticancer Research February 2021, 41 (2) 671-678; DOI: https://doi.org/10.21873/anticanres.14818
HYUN JUNG KIM
Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul, Republic of Korea
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KYUN HEO
Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul, Republic of Korea
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  • For correspondence: kyunheo@kookmin.ac.kr
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Abstract

Background/Aim: Hepatocyte growth factor (HGF) acts as a key regulator in promoting ovarian cancer metastasis. Previously, we observed that YYB-101, a humanized anti-HGF antibody, effectively inhibits ovarian cancer cell migration, invasion, and progression. Here, we evaluated the signaling mechanisms affected by YYB-101 that are important in ovarian cancer cell progression. Materials and Methods: Using cell migration, invasion and proliferation assays, we evaluated the effects of YYB-101 on A2780/luc and SKOV3 cells. The effects of YYB-101 on signaling molecules were determined by immunocytochemistry and immunoblot analysis. Results: YYB-101 inhibited HGF-induced ovarian cancer cell motility by down-regulating paxillin phosphorylation and actin-cytoskeleton rearrangement. Also, YYB-101 inhibited ovarian cancer cell proliferation by reducing c-MET phosphorylation and activating apoptosis in vitro and in vivo. These effects were significantly enhanced by combining YYB-101 treatment with paclitaxel, a standard chemotherapy drug. Conclusion: YYB-101 can be examined as a new therapeutic agent for the treatment of patients with ovarian cancer.

Key Words:
  • Hepatocyte growth factor
  • c-MET
  • ovarian cancer
  • humanized monoclonal antibody
  • apoptosis
  • Received December 12, 2020.
  • Revision received December 27, 2020.
  • Accepted December 28, 2020.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (2)
Anticancer Research
Vol. 41, Issue 2
February 2021
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YYB-101, a Humanized Antihepatocyte Growth Factor Monoclonal Antibody, Inhibits Ovarian Cancer Cell Motility and Proliferation
HYUN JUNG KIM, KYUN HEO
Anticancer Research Feb 2021, 41 (2) 671-678; DOI: 10.21873/anticanres.14818

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YYB-101, a Humanized Antihepatocyte Growth Factor Monoclonal Antibody, Inhibits Ovarian Cancer Cell Motility and Proliferation
HYUN JUNG KIM, KYUN HEO
Anticancer Research Feb 2021, 41 (2) 671-678; DOI: 10.21873/anticanres.14818
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Keywords

  • Hepatocyte growth factor
  • c-MET
  • Ovarian cancer
  • humanized monoclonal antibody
  • apoptosis
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