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Research ArticleClinical Studies

A Case of Rare Matrix-producing Triple-negative Breast Carcinoma for Which Drug Response in a Patient-derived Orthotopic Xenograft Mouse Model Was Correlated With Patient Response

TSUNEHISA NOMURA, JUNICHI KUREBAYASHI, TAKUYA MORIYA, WATARU SAITO, TAKUYA MURATA, JUN YAMAMOTO, CHIHIRO HOZUMI and ROBERT M. HOFFMAN
Anticancer Research December 2021, 41 (12) 6191-6197; DOI: https://doi.org/10.21873/anticanres.15438
TSUNEHISA NOMURA
1Department of Breast and Thyroid Surgery, Kawasaki Medical School, Kurashiki, Japan;
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  • For correspondence: somoejo{at}med.kawasaki-m.ac.jp
JUNICHI KUREBAYASHI
1Department of Breast and Thyroid Surgery, Kawasaki Medical School, Kurashiki, Japan;
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TAKUYA MORIYA
2Department of Pathology, Kawasaki Medical School, Kurashiki, Japan;
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WATARU SAITO
1Department of Breast and Thyroid Surgery, Kawasaki Medical School, Kurashiki, Japan;
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TAKUYA MURATA
3Department of Obstetrics and Gynecology 2, Kawasaki Medical School, Kurashiki, Japan;
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JUN YAMAMOTO
4AntiCancer Inc, San Diego, CA, U.S.A.;
5Department of Surgery, UCSD, San Diego, CA, U.S.A.;
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CHIHIRO HOZUMI
6AntiCancer Japan Inc, Narita, Japan
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ROBERT M. HOFFMAN
4AntiCancer Inc, San Diego, CA, U.S.A.;
5Department of Surgery, UCSD, San Diego, CA, U.S.A.;
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    Figure 1.

    Matrix-producing breast carcinoma imaging findings. A: Breast ultrasound sonogram showed a lobulated hypoechoic mass that was well-defined with a rough border and heterogeneous echo in internal structure. B: Contrast-enhanced computed tomography revealed a peripheral ring enhancement (arrow) in the breast tumor. C: Contrast-enhanced T2-weighted magnetic resonance imaging showed a ring-enhanced appearance in the tumor (arrow).

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    Figure 2.

    Matrix-producing breast carcinoma microscopic findings (hematoxylin and eosin staining). A: The tumor was relatively well-circumscribed, and viable cancer cells were located on the periphery (arrows) (×20). B: Invasive carcinoma, with trabecular cell nests, was seen, and a chondromyxoid matrix was attached (arrows) (×100).

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    Figure 3.

    Metastatic carcinoma of the ovary. A: The right ovary was enlarged and was totally replaced by metastatic tumor (arrows) (hematoxylin and eosin staining, ×20). B: The tumor histology was consistent with metastatic breast carcinoma (arrows)(hematoxylin and eosin staining, ×200). C: Programmed cell-death ligand 1 (PD-L1; clone SP142; ×400) staining was positive for tumor-infiltrating immune cells (black stain).

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    Figure 4.

    Computed tomography images before (A, B) and after (C, D) eribulin therapy. A rapid enlargement of the thyroid gland (red arrows) and cervical (yellow arrows) and mediastinal lymph nodes (blue arrows) was observed after eribulin therapy.

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Anticancer Research
Vol. 41, Issue 12
December 2021
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A Case of Rare Matrix-producing Triple-negative Breast Carcinoma for Which Drug Response in a Patient-derived Orthotopic Xenograft Mouse Model Was Correlated With Patient Response
TSUNEHISA NOMURA, JUNICHI KUREBAYASHI, TAKUYA MORIYA, WATARU SAITO, TAKUYA MURATA, JUN YAMAMOTO, CHIHIRO HOZUMI, ROBERT M. HOFFMAN
Anticancer Research Dec 2021, 41 (12) 6191-6197; DOI: 10.21873/anticanres.15438

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A Case of Rare Matrix-producing Triple-negative Breast Carcinoma for Which Drug Response in a Patient-derived Orthotopic Xenograft Mouse Model Was Correlated With Patient Response
TSUNEHISA NOMURA, JUNICHI KUREBAYASHI, TAKUYA MORIYA, WATARU SAITO, TAKUYA MURATA, JUN YAMAMOTO, CHIHIRO HOZUMI, ROBERT M. HOFFMAN
Anticancer Research Dec 2021, 41 (12) 6191-6197; DOI: 10.21873/anticanres.15438
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  • High Clinical Concordance of Drug Resistance in Patient-derived Orthotopic Xenograft (PDOX) Mouse Models: First Step to Validated Precise Individualized Cancer Chemotherapy
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Keywords

  • Matrix-producing breast carcinoma
  • triple-negative
  • Patient-derived orthotopic xenograft
  • PDOX
  • eribulin
  • paclitaxel
  • bevacizumab
  • clinical correlation
  • concordance
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