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Research ArticleExperimental Studies

miR-3188 Enhances Sensitivity of Breast Cancer Cells to Ionizing Radiation by Down-regulating Rictor

SUNG-EUN HONG, HYEON-OK JIN, SEUNG-MI KIM, SE-KYEONG JANG, CHAN SUB PARK, MIN-KI SEONG, HYUN-AH KIM, WOO CHUL NOH and IN-CHUL PARK
Anticancer Research December 2021, 41 (12) 6169-6176; DOI: https://doi.org/10.21873/anticanres.15436
SUNG-EUN HONG
1KIRAMS Radiation Biobank, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea;
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HYEON-OK JIN
1KIRAMS Radiation Biobank, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea;
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SEUNG-MI KIM
1KIRAMS Radiation Biobank, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea;
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SE-KYEONG JANG
2Division of Fusion Radiology Research, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea;
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CHAN SUB PARK
3Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea;
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MIN-KI SEONG
3Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea;
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HYUN-AH KIM
3Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea;
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WOO CHUL NOH
4Department of Surgery, Konkuk University Medical Center, Seoul, Republic of Korea
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  • For correspondence: 20210415@kuh.ac.kr parkic@kirams.re.kr
IN-CHUL PARK
2Division of Fusion Radiology Research, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea;
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  • For correspondence: 20210415@kuh.ac.kr parkic@kirams.re.kr
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Abstract

Background/Aim: Rictor is an adaptor protein essential for mTORC2, which regulates cell growth and survival. The aim of this study was to identify microRNAs (miR) that down-regulate Rictor and investigate their function on breast cancer cell survival. Materials and Methods: Trypan blue assay, MTT assay, polymerase chain reaction analysis, luciferase reporter assay and western blot analysis were carried out in breast cancer cell lines HCC1954, MDA-MB-231, SK-BR-3, and BT474. Results: miR-3188 overexpression suppressed the expression of Rictor and inhibited cell viability in HCC1954 and MDA-MB-231, highly Rictor-expressing breast cancer cells. In addition, miR-3188 overexpression decreased the protein level of p-AKT at Ser473, a substrate of mTORC2. Moreover, miRNA-3188 overexpression sensitized breast cancer cells to ionizing radiation (IR) by down-regulating Rictor and p-AKT. Conclusion: miR-3188 enhances IR sensitivity by affecting the mTORC2/AKT signalling pathway by altering the expression of Rictor, which could be a promising therapeutic strategy for the future treatment of breast cancer.

Key Words:
  • Breast cancer
  • ionizing radiation
  • miR-3188
  • Rictor
  • Received September 16, 2021.
  • Revision received October 10, 2021.
  • Accepted October 27, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (12)
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December 2021
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miR-3188 Enhances Sensitivity of Breast Cancer Cells to Ionizing Radiation by Down-regulating Rictor
SUNG-EUN HONG, HYEON-OK JIN, SEUNG-MI KIM, SE-KYEONG JANG, CHAN SUB PARK, MIN-KI SEONG, HYUN-AH KIM, WOO CHUL NOH, IN-CHUL PARK
Anticancer Research Dec 2021, 41 (12) 6169-6176; DOI: 10.21873/anticanres.15436

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miR-3188 Enhances Sensitivity of Breast Cancer Cells to Ionizing Radiation by Down-regulating Rictor
SUNG-EUN HONG, HYEON-OK JIN, SEUNG-MI KIM, SE-KYEONG JANG, CHAN SUB PARK, MIN-KI SEONG, HYUN-AH KIM, WOO CHUL NOH, IN-CHUL PARK
Anticancer Research Dec 2021, 41 (12) 6169-6176; DOI: 10.21873/anticanres.15436
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Keywords

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