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Research ArticleExperimental Studies

The Thioredoxin-1 Inhibitor, PX-12, Suppresses Local Osteosarcoma Progression

HIDEYUKI KINOSHITA, OSAMU SHIMOZATO, TAKESHI ISHII, HIROTO KAMODA, YOKO HAGIWARA, SEIJI OHTORI and TSUKASA YONEMOTO
Anticancer Research December 2021, 41 (12) 6013-6021; DOI: https://doi.org/10.21873/anticanres.15420
HIDEYUKI KINOSHITA
1Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan;
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  • For correspondence: kinoshi1783{at}yahoo.co.jp
OSAMU SHIMOZATO
2Laboratory of Oncogenomics, Chiba Cancer Center Research Institute, Chiba, Japan;
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TAKESHI ISHII
1Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan;
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HIROTO KAMODA
1Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan;
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YOKO HAGIWARA
1Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan;
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SEIJI OHTORI
3Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
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TSUKASA YONEMOTO
1Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan;
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Article Information

vol. 41 no. 12 6013-6021
DOI 
https://doi.org/10.21873/anticanres.15420
PMID 
34848455

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received October 2, 2021
  • Revision received October 30, 2021
  • Accepted November 1, 2021
  • Published online November 30, 2021.

Copyright & Usage 
Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. HIDEYUKI KINOSHITA1⇑,
  2. OSAMU SHIMOZATO2,
  3. TAKESHI ISHII1,
  4. HIROTO KAMODA1,
  5. YOKO HAGIWARA1,
  6. SEIJI OHTORI3 and
  7. TSUKASA YONEMOTO1
  1. 1Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan;
  2. 2Laboratory of Oncogenomics, Chiba Cancer Center Research Institute, Chiba, Japan;
  3. 3Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
  1. Correspondence to: Hideyuki Kinoshita, Department of Orthopedic Surgery, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, Japan. Tel: +81 432645431, Fax: +81 432628680, e-mail: kinoshi1783{at}yahoo.co.jp
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December 2021
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The Thioredoxin-1 Inhibitor, PX-12, Suppresses Local Osteosarcoma Progression
HIDEYUKI KINOSHITA, OSAMU SHIMOZATO, TAKESHI ISHII, HIROTO KAMODA, YOKO HAGIWARA, SEIJI OHTORI, TSUKASA YONEMOTO
Anticancer Research Dec 2021, 41 (12) 6013-6021; DOI: 10.21873/anticanres.15420

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The Thioredoxin-1 Inhibitor, PX-12, Suppresses Local Osteosarcoma Progression
HIDEYUKI KINOSHITA, OSAMU SHIMOZATO, TAKESHI ISHII, HIROTO KAMODA, YOKO HAGIWARA, SEIJI OHTORI, TSUKASA YONEMOTO
Anticancer Research Dec 2021, 41 (12) 6013-6021; DOI: 10.21873/anticanres.15420
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Keywords

  • osteosarcoma
  • thioredoxin
  • PX-12
  • oxidative stress
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