Anticancer Research: 41 (12)

December 2021; Volume 41,Issue 12

Special Issue on New Anticancer Agents

Reviews

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Osteosarcoma Patient-derived Orthotopic Xenograft (PDOX) Models Used to Identify Novel and Effective Therapeutics: A Review
TAKASHI HIGUCHI, KENTARO IGARASHI, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, MICHAEL BOUVET, HIROYUKI TSUCHIYA and ROBERT M. HOFFMAN

Anticancer Research December 2021, 41 (12) 5865-5871; DOI: https://doi.org/10.21873/anticanres.15406
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New Insights as to Why Progesterone Receptor Modulators, such as Mifepristone, Seem to Be More Effective in Treating Cancers that Are Devoid of the Classical Nuclear Progesterone Receptor
JEROME H. CHECK and DIANE CHECK

Anticancer Research December 2021, 41 (12) 5873-5880; DOI: https://doi.org/10.21873/anticanres.15407
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Targeting Production of Reactive Oxygen Species as an Anticancer Strategy
GRIGORIA-KALLIOPI MARIOLI-SAPSAKOU and MALAMATI KOURTI

Anticancer Research December 2021, 41 (12) 5881-5902; DOI: https://doi.org/10.21873/anticanres.15408
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Effects of Circulating 25(OH)D Status in Advanced Colorectal Cancer Patients Undergoing Chemotherapy: A Systematic Review
XIAOFENG ZENG, LIYING ZHANG, SHULI JIA, TAIPING LIN, GONGXIANG LIU, JIRONG YUE and XIAOLI HUANG

Anticancer Research December 2021, 41 (12) 5903-5912; DOI: https://doi.org/10.21873/anticanres.15409
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Repurposing Metformin for Cancer Treatment: A Great Challenge of a Promising Drug
CHARUPONG SAENGBOONMEE, THANACHAI SANLUNG and SOPIT WONGKHAM

Anticancer Research December 2021, 41 (12) 5913-5918; DOI: https://doi.org/10.21873/anticanres.15410

Experimental Studies

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Effect of Diallyl Trisulfide on TNF-α-induced CCL2/MCP-1 Release in Genetically Different Triple-negative Breast Cancer Cells
KONAN J.W. KANGA, PATRICIA MENDONCA, KARAM F.A. SOLIMAN, DOMINIQUE T. FERGUSON and SELINA F. DARLING-REED

Anticancer Research December 2021, 41 (12) 5919-5933; DOI: https://doi.org/10.21873/anticanres.15411
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Activity in MCF-7 Estrogen-sensitive Breast Cancer Cells of Capsicodendrin from Cinnamosma fragrans
ULYANA MUNOZ ACUNA, NATHAN EZZONE, L. HARINANTENAINA RAKOTONDRAIBE and ESPERANZA J. CARCACHE DE BLANCO

Anticancer Research December 2021, 41 (12) 5935-5944; DOI: https://doi.org/10.21873/anticanres.15412
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Harnessing the Power of Kiwifruit for Radiosensitization of Melanoma
LEON KOU, ZIWEN ZHU, EMERSON FAJARDO, QIAN BAI, CHASE REDINGTON, HUAPING XIAO, MARCO LEQUIO, NELSON SHAM, MARK R. WAKEFIELD and YUJIANG FANG

Anticancer Research December 2021, 41 (12) 5945-5951; DOI: https://doi.org/10.21873/anticanres.15413
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Reduction in Copper Uptake and Inhibition of Prostate Cancer Cell Proliferation by Novel Steroid-based Compounds
FANG XIE and FANGYU PENG

Anticancer Research December 2021, 41 (12) 5953-5958; DOI: https://doi.org/10.21873/anticanres.15414
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GLO 1 and PKCλ Regulate ALDH1-positive Breast Cancer Stem Cell Survival
HITOMI MOTOMURA, SHOMA TAMORI, MASA-AKI YATANI, AYANO NAMIKI, CHOTARO ONAGA, AYAKA OZAKI, RYOKO TAKASAWA, YASUNARI MANO, TSUGUMICHI SATO, YASUSHI HARA, KEIKO SATO, YUYUN XIONG, YOHSUKE HARADA, TAKEHISA HANAWA, SEI-ICHI TANUMA, KAZUNORI SASAKI, SHIGEO OHNO and KAZUNORI AKIMOTO

Anticancer Research December 2021, 41 (12) 5959-5971; DOI: https://doi.org/10.21873/anticanres.15415
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The Novel, Orally Bioavailable CDK9 Inhibitor Atuveciclib Sensitises Pancreatic Cancer Cells to TRAIL-induced Cell Death
JAN-PHILIPP RUFF, ANNA-LAURA KRETZ, MARKO KORNMANN, DORIS HENNE-BRUNS, JOHANNES LEMKE and BENNO TRAUB

Anticancer Research December 2021, 41 (12) 5973-5985; DOI: https://doi.org/10.21873/anticanres.15416
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The Dual Histone Deacetylase-Proteasome Inhibitor RTS-V5 Acts Synergistically With Ritonavir to Induce Endoplasmic Reticulum Stress in Bladder Cancer Cells
KAZUKI OKUBO, NINA REßING, WOLFGANG A. SCHULZ, FINN K. HANSEN, TAKAKO ASANO and AKINORI SATO

Anticancer Research December 2021, 41 (12) 5987-5996; DOI: https://doi.org/10.21873/anticanres.15417
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Effects of Rhenium(I)-diselenoether and of its Diselenide Ligand on the Production of Cathepsins B and S by MDA-MB231 Breast Malignant Cells
PHILIPPE COLLERY, VIJAYKUMAR VEENA, DIDIER DESMAËLE, ADHIKESAVAN HARIKRISHNAN and BASAVEGOWDA LAKSHMI

Anticancer Research December 2021, 41 (12) 5997-6001; DOI: https://doi.org/10.21873/anticanres.15418
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Intravenous Administration of Dehydroxymethylepoxyquinomicin With Polymer Enhances the Inhibition of Pancreatic Carcinoma Growth in Mice
HIROTO FUJISAKI, YUTAKA NAKANO, SACHIKO MATSUDA, KEIICHI SUZUKI, OSAMU ITANO, MASAYUKI TANAKA, SHUTARO HORI, YASUSHI HASEGAWA, YUTA ABE, HIROSHI YAGI, MINORU KITAGO, TOMOHIRO KONNO, KAZUHIKO ISHIHARA, KEIKO OHNO, SATOSHI KISHINO, KAZUO UMEZAWA and YUKO KITAGAWA

Anticancer Research December 2021, 41 (12) 6003-6012; DOI: https://doi.org/10.21873/anticanres.15419
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The Thioredoxin-1 Inhibitor, PX-12, Suppresses Local Osteosarcoma Progression
HIDEYUKI KINOSHITA, OSAMU SHIMOZATO, TAKESHI ISHII, HIROTO KAMODA, YOKO HAGIWARA, SEIJI OHTORI and TSUKASA YONEMOTO

Anticancer Research December 2021, 41 (12) 6013-6021; DOI: https://doi.org/10.21873/anticanres.15420
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Metabolic Alteration in Cancer Cells by Therapeutic Carbon Ions
NAOTO OSU, HIDEKI MAKINOSHIMA, TAKAHIRO OIKE and TATSUYA OHNO

Anticancer Research December 2021, 41 (12) 6023-6029; DOI: https://doi.org/10.21873/anticanres.15421
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Characteristics of Human Peripheral Blood γδ T Cells Expanded With Zoledronate
MINSONG KIM, HYORI KIM, MINA HAN, HYUN JU HWANG, HYERY KIM, HO JOON IM, NAYOUNG KIM and KYUNG-NAM KOH

Anticancer Research December 2021, 41 (12) 6031-6038; DOI: https://doi.org/10.21873/anticanres.15422
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Efficacy of a Novel Oral Chemotherapeutic Agent, TAS-102, Against Human Oral Squamous Cell Carcinoma Cells
KOJI HARADA, TARANNUM FERDOUS and KATSUAKI MISHIMA

Anticancer Research December 2021, 41 (12) 6039-6049; DOI: https://doi.org/10.21873/anticanres.15423
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Evaluation of Erastin as a Therapeutic Agent Under Hypoxic Conditions in Pancreatic Cancer Cells
SATOSHI OWADA, HITOSHI ENDO, YUKARI SHIDA, TAKAAKI KINOUE, HIROYUKI FURUYA and MASAYUKI TATEMICHI

Anticancer Research December 2021, 41 (12) 6051-6059; DOI: https://doi.org/10.21873/anticanres.15424
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Activity of Free and Liposomal Antimony Trioxide in the Acute Promyelocytic Leukemia Cell Line NB4
ALTEVIR ROSSATO VIANA, CAROLINA BORDIN DAVIDSON, BRUNO SALLES, LUCIANA YAMAMOTO DE ALMEIDA, ALEXANDRE KRAUSE, CEZAR AUGUSTO BIZZI, EDUARDO MAGALHAES REGO, LUCIANA MARIA FONTANARI KRAUSE and SERGIO ROBERTO MORTARI

Anticancer Research December 2021, 41 (12) 6061-6065; DOI: https://doi.org/10.21873/anticanres.15425
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Pharmacological Strategy for Selective Targeting of Glioblastoma by Redox-active Combination Drug – Comparison With the Chemotherapeutic Standard-of-care Temozolomide
AKIRA SUMIYOSHI, SAYAKA SHIBATA, ZHIVKO ZHELEV, THOMAS MILLER, DESSISLAVA LAZAROVA, GENOVEVA ZLATEVA, ICHIO AOKI and RUMIANA BAKALOVA

Anticancer Research December 2021, 41 (12) 6067-6076; DOI: https://doi.org/10.21873/anticanres.15426
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Combinational Anti-tumor Effects of Chemicals from Paeonia lutea Leaf Extract in Oral Squamous Cell Carcinoma Cells
SHINSUKE NAKAMURA, YOSHIKI MUKUDAI, JUNICHIRO CHIKUDA, MEILIN ZHANG, HIDEYUKI SHIGEMORI, KAZUNAGA YAZAWA, SEIJI KONDO, TOSHIKAZU SHIMANE and TATSUO SHIROTA

Anticancer Research December 2021, 41 (12) 6077-6086; DOI: https://doi.org/10.21873/anticanres.15427
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A DNA Topoisomerase II Inhibitor Results in Ex Vivo Differentiation of THP-1 Cells and Activation of Dendritic Cells
YOUNG JIN CHO, HEEJAE LEE, JIHYEONG KIM, GYUNGYUB GONG, HEE JIN LEE and IN AH PARK

Anticancer Research December 2021, 41 (12) 6087-6094; DOI: https://doi.org/10.21873/anticanres.15428
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Cetyltrimethylammonium Bromide Disrupts Mesenchymal Characteristics of Human Tongue Squamous Cell Carcinoma SCC4 Cells Through Modulating Canonical TGF-β/Smad/miR-181b/TIMP3 Signaling Pathway
CHIA-HERNG YUE, CHUNG-HUNG CHEN, YING-RU PAN, YI-PING CHEN, FU-MEI HUANG and CHIA-JEN LEE

Anticancer Research December 2021, 41 (12) 6095-6104; DOI: https://doi.org/10.21873/anticanres.15429
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Differences in Transport Characteristics and Cytotoxicity of Epirubicin and Doxorubicin in HepG2 and A549 Cells
KATSUHITO NAGAI, SHUHEI FUKUNO, MAHO SHIOTA, MAYUKO TAMURA, SAYAKA YABUMOTO and HIROKI KONISHI

Anticancer Research December 2021, 41 (12) 6105-6112; DOI: https://doi.org/10.21873/anticanres.15430
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Suppressive Effects of Anisomycin on the Proliferation of B16 Mouse Melanoma Cells In Vitro
HIRONORI USHIJIMA, RINA MONZAKI and ARISA ONODERA

Anticancer Research December 2021, 41 (12) 6113-6121; DOI: https://doi.org/10.21873/anticanres.15431
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Flaccidoxide Induces Apoptosis Through Down-regulation of PI3K/AKT/mTOR/p70S6K Signaling in Human Bladder Cancer Cells
BING-SANG WONG, WEN-TUNG WU, JUI-HSIN SU, YIH-GANG GOAN and YU-JEN WU

Anticancer Research December 2021, 41 (12) 6123-6133; DOI: https://doi.org/10.21873/anticanres.15432
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RGS2 Suppresses Melanoma Growth via Inhibiting MAPK and AKT Signaling Pathways
SHENG-JIA LIN, YIN-CHENG HUANG, HAO-YUAN CHEN, JIA-YOU FANG, SHU-YUAN HSU, HUNG-YU SHIH, YU-CHIEN LIU and YI-CHUAN CHENG

Anticancer Research December 2021, 41 (12) 6135-6145; DOI: https://doi.org/10.21873/anticanres.15433
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Pongamol Inhibits Epithelial to Mesenchymal Transition Through Suppression of FAK/Akt-mTOR Signaling
HARDYANTI EKA PUTRI, BOONCHOO SRITULARAK and PITHI CHANVORACHOTE

Anticancer Research December 2021, 41 (12) 6147-6154; DOI: https://doi.org/10.21873/anticanres.15434
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Sequence of CX-4945 and Cisplatin Administration Determines the Effectiveness of Drug Combination and Cellular Response in Cholangiocarcinoma Cells In Vitro
JOMNARONG LERTSUWAN, ANYAPORN SAWASDICHAI, NATHAPOL TASNAWIJITWONG, KEVIN GASTON, PADMA-SHEELA JAYARAMAN and JUTAMAAD SATAYAVIVAD

Anticancer Research December 2021, 41 (12) 6155-6167; DOI: https://doi.org/10.21873/anticanres.15435
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miR-3188 Enhances Sensitivity of Breast Cancer Cells to Ionizing Radiation by Down-regulating Rictor
SUNG-EUN HONG, HYEON-OK JIN, SEUNG-MI KIM, SE-KYEONG JANG, CHAN SUB PARK, MIN-KI SEONG, HYUN-AH KIM, WOO CHUL NOH and IN-CHUL PARK

Anticancer Research December 2021, 41 (12) 6169-6176; DOI: https://doi.org/10.21873/anticanres.15436
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Sensitization Effects of Repurposed Blood Pressure-regulating Drugs on Drug-resistant Cancer Cells
CHUNXUE JIANG, TIAN ZHENG, JAE HYEON PARK, JIN-SOL LEE, YUNMOON OH, AMIT KUNDU, HYUNG SIK KIM and SUNGPIL YOON

Anticancer Research December 2021, 41 (12) 6179-6190; DOI: https://doi.org/10.21873/anticanres.15437

Clinical Studies

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A Case of Rare Matrix-producing Triple-negative Breast Carcinoma for Which Drug Response in a Patient-derived Orthotopic Xenograft Mouse Model Was Correlated With Patient Response
TSUNEHISA NOMURA, JUNICHI KUREBAYASHI, TAKUYA MORIYA, WATARU SAITO, TAKUYA MURATA, JUN YAMAMOTO, CHIHIRO HOZUMI and ROBERT M. HOFFMAN

Anticancer Research December 2021, 41 (12) 6191-6197; DOI: https://doi.org/10.21873/anticanres.15438
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A Multicentre Retrospective Study of Nivolumab Plus Ipilimumab for Untreated Metastatic Renal Cell Carcinoma
RENPEI KATO, TAKAHIRO KOJIMA, TOMOKAZU SAZUKA, HAYATO YAMAMOTO, SHOHEI FUKUDA, KAZUTOSHI YAMANA, YUSUKE SUGINO, SHUZO HAMAMOTO, NOBORU NAKAIGAWA, KOKI KABU, HIROSHI MURAKAMI and WATARU OBARA

Anticancer Research December 2021, 41 (12) 6199-6209; DOI: https://doi.org/10.21873/anticanres.15439
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The Efficacy and Safety of Trifluridine/Tipiracil Treatment for Elderly Patients With Metastatic Colorectal Cancer in a Real-world Setting
MASATSUNE SHIBUTANI, WANG EN, YUKI OKAZAKI, SHINICHIRO KASHIWAGI, TATSUNARI FUKUOKA, YASUHITO ISEKI, KOSEI HIRAKAWA and MASAICHI OHIRA

Anticancer Research December 2021, 41 (12) 6211-6216; DOI: https://doi.org/10.21873/anticanres.15440
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Comparison of Treatment Completion Rate Between Conventional and Dose-dense Doxorubicin and Cyclophosphamide (AC) Followed by a Taxane in Patients With Breast Cancer: A Propensity Score-matched Analysis
KANAKO MAMISHIN, YOICHI NAITO, SHOGO NOMURA, GAKUTO OGAWA, KUMI NIGUMA, KAEDE BABA, SAEKO SAKAEDA, HIROMICHI NAKAJIMA, SHOTA KUSUHARA, CHIKAKO FUNASAKA, TAKEHIRO NAKAO, YOKO FUKASAWA, CHIHIRO KONDOH, KENICHI HARANO, TAKAHIRO KOGAWA, NOBUAKI MATSUBARA, AKO HOSONO, TOSHIKATSU KAWASAKI and TORU MUKOHARA

Anticancer Research December 2021, 41 (12) 6217-6224; DOI: https://doi.org/10.21873/anticanres.15441
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Immune Checkpoint Inhibitor as a Therapeutic Choice for Double Cancer: A Case Series
HIROSHI AOKI, NAOKI MATSUMOTO, HIROSHI TAKAHASHI, MASAYUKI HONDA, TOMOHIRO KANEKO, SHUHEI ARIMA, TOMOTAKA ISHII, TAKU MIZUTANI, RYOTA MASUZAKI, KAZUSHIGE NIREI, HIROAKI YAMAGAMI, MASAHIRO OGAWA, TATSUO KANDA, MITSUHIKO MORIYAMA and KATSUHIRO MIURA

Anticancer Research December 2021, 41 (12) 6225-6230; DOI: https://doi.org/10.21873/anticanres.15442
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Effect of Monoammonium Glycyrrhizinate on the Development of Hepatotoxicity After Initial Intrathecal Chemotherapy for Leukemia
KENJI KISHIMOTO, DAIICHIRO HASEGAWA, SUGURU UEMURA, SAYAKA NAKAMURA, AIKO KOZAKI, ATSURO SAITO, TOSHIAKI ISHIDA, TAKESHI MORI and YOSHIYUKI KOSAKA

Anticancer Research December 2021, 41 (12) 6231-6236; DOI: https://doi.org/10.21873/anticanres.15443
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Prospective Randomized Trial of Early Postoperative Enteral and Total Parenteral Nutrition for Treating Esophageal Cancer
YOICHI HAMAI, JUN HIHARA, MANABU EMI, YUTA IBUKI, TOMOAKI KUROKAWA, TORU YOSHIKAWA, RYOSUKE HIROHATA, MANATO OHSAWA, NAO KITASAKI and MORIHITO OKADA

Anticancer Research December 2021, 41 (12) 6237-6246; DOI: https://doi.org/10.21873/anticanres.15444
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Phase II Study of Preoperative Chemoradiotherapy With S-1 Plus Oxaliplatin for Locally Advanced Rectal Cancer (PerSeUS-RC01)
NOBUHISA MATSUHASHI, TAKAO TAKAHASHI, CHIHIRO TANAKA, KAZUNORI YAWATA, MAKOTO YAMADA, YOSHINORI IWATA, SHIGERU KIYAMA, CHIKA MIZUTANI, JESSE YU TAJIMA, TAKUMA ISHIHARA and KAZUHIRO YOSHIDA

Anticancer Research December 2021, 41 (12) 6247-6257; DOI: https://doi.org/10.21873/anticanres.15445
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Efficacy and Safety of Induction Chemotherapy and/or External Beam Radiotherapy Followed by Brachytherapy in Patients With Tongue Cancer
RYO-ICHI YOSHIMURA, KAZUMA TODA, HIROSHI WATANABE, ATSUSHI KAIDA, HIROYUKI HARADA, TAKAHIRO ASAKAGE and MASAHIKO MIURA

Anticancer Research December 2021, 41 (12) 6259-6266; DOI: https://doi.org/10.21873/anticanres.15446
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CTLA-4 Expression in Tumor-infiltrating Lymphocytes Is Irrelevant to PD-L1 Expression in NSCLC
SATOSHI MUTO, SHO INOMATA, HIKARU YAMAGUCHI, HAYATO MINE, HIRONORI TAKAGI, YUKI OZAKI, MASAYUKI WATANABE, TAKUYA INOUE, TAKUMI YAMAURA, MITSURO FUKUHARA, NAOYUKI OKABE, YUKI MATSUMURA, TAKEO HASEGAWA, JUN OSUGI, MIKA HOSHINO, MITSUNORI HIGUCHI, YUTAKA SHIO and HIROYUKI SUZUKI

Anticancer Research December 2021, 41 (12) 6267-6272; DOI: https://doi.org/10.21873/anticanres.15447
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Doxorubicin Combined With Ifosfamide for Sarcoma Induces Muscle Atrophy and Sleep Disruption
HIDEYUKI KINOSHITA, YOKO HAGIWARA, TAKESHI ISHII, HIROTO KAMODA, TOSHINORI TSUKANISHI, SEIJI OHTORI and TSUKASA YONEMOTO

Anticancer Research December 2021, 41 (12) 6273-6278; DOI: https://doi.org/10.21873/anticanres.15448
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Effect of Concomitant Lafutidine on Adjuvant S-1 for Head and Neck Cancer: A Comparative Study
KOICHIRO YOSHINO, ISAKU OKAMOTO, HIROKI SATO, TAKURO OKADA, KUNIHIKO TOKASHIKI, TAKAHITO KONDO and KIYOAKI TSUKAHARA

Anticancer Research December 2021, 41 (12) 6279-6285; DOI: https://doi.org/10.21873/anticanres.15449
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Applicability of the Histoculture Drug Response Assay to Predict Platinum Sensitivity and Prognosis in Ovarian Cancer
JUHUN LEE, JONG MI KIM, YOON HEE LEE, GUN OH CHONG and DAE GY HONG

Anticancer Research December 2021, 41 (12) 6287-6292; DOI: https://doi.org/10.21873/anticanres.15450

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Special Issue on New Anticancer Agents

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