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Research ArticleClinical Studies

Far-advanced Colorectal Liver Metastases Successfully Managed With Modified ALPPS and Radiofrequency Ablation in Combination With Chemotherapy

YUKI ADACHI, KENSUKE YAMAMURA, SHINSEI YUMOTO, TAKAAKI HIGASHI, HIROYUKI ISHIODORI, SHINOBU HONDA, YOSHIHIRO HARA, KAZUKI MATSUMURA, ERI ODA, SHINICHI AKAHOSHI, HIDEAKI YUKI, HIDEAKI MIYAMOTO, KOICHI DOI and TORU BEPPU
Anticancer Research November 2021, 41 (11) 5855-5861; DOI: https://doi.org/10.21873/anticanres.15405
YUKI ADACHI
1Department of Surgery, Miyazaki Nobeoka Prefectural Hospital, Nobeoka, Japan;
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KENSUKE YAMAMURA
2Department of Surgery, Yamaga City Medical Center, Yamaga, Japan;
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SHINSEI YUMOTO
1Department of Surgery, Miyazaki Nobeoka Prefectural Hospital, Nobeoka, Japan;
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TAKAAKI HIGASHI
1Department of Surgery, Miyazaki Nobeoka Prefectural Hospital, Nobeoka, Japan;
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HIROYUKI ISHIODORI
1Department of Surgery, Miyazaki Nobeoka Prefectural Hospital, Nobeoka, Japan;
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SHINOBU HONDA
1Department of Surgery, Miyazaki Nobeoka Prefectural Hospital, Nobeoka, Japan;
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YOSHIHIRO HARA
1Department of Surgery, Miyazaki Nobeoka Prefectural Hospital, Nobeoka, Japan;
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KAZUKI MATSUMURA
1Department of Surgery, Miyazaki Nobeoka Prefectural Hospital, Nobeoka, Japan;
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ERI ODA
2Department of Surgery, Yamaga City Medical Center, Yamaga, Japan;
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SHINICHI AKAHOSHI
2Department of Surgery, Yamaga City Medical Center, Yamaga, Japan;
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HIDEAKI YUKI
3Department of Radiology, Yamaga City Medical Center, Yamaga, Japan;
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HIDEAKI MIYAMOTO
4Department of Medical Oncology, Yamaga City Medical Center, Kumamoto, Japan
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KOICHI DOI
1Department of Surgery, Miyazaki Nobeoka Prefectural Hospital, Nobeoka, Japan;
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TORU BEPPU
2Department of Surgery, Yamaga City Medical Center, Yamaga, Japan;
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  • For correspondence: tbeppu@yamaga-mc.jp
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Abstract

Background: Large numbers of synchronous colorectal liver metastases are associated with poor prognosis. Case Report: A 47-year-old male patient with rectal cancer and unresectable colorectal liver metastases (over 15 cm in diameter and over 30 metastases) was treated with a multidisciplinary treatment including systemic chemotherapy with mFOLFOX6/panitumumab and surgical therapies (colostomy, modified associating liver partition and portal vein ligation for staged hepatectomy together with radiofrequency ablation). For solitary recurrent colorectal liver metastases, percutaneous radiofrequency ablation with chemoembolization and open radiofrequency ablation in combination with the same systemic chemotherapy was performed. Since the diagnosis 3 years ago, he has been leading a good quality of life, free of any tumor or treatment. Conclusion: For patients with far-advanced but liver-only colorectal liver metastases, surgical therapy, systemic chemotherapy, and interventional treatment can be important for achieving good prognosis.

Key Words:
  • Liver partition
  • portal vein ligation
  • staged hepatectomy
  • colorectal liver metastases
  • multidisciplinary treatment
  • radiofrequency ablation
  • systemic chemotherapy
  • Received September 6, 2021.
  • Revision received October 14, 2021.
  • Accepted October 18, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (11)
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November 2021
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Far-advanced Colorectal Liver Metastases Successfully Managed With Modified ALPPS and Radiofrequency Ablation in Combination With Chemotherapy
YUKI ADACHI, KENSUKE YAMAMURA, SHINSEI YUMOTO, TAKAAKI HIGASHI, HIROYUKI ISHIODORI, SHINOBU HONDA, YOSHIHIRO HARA, KAZUKI MATSUMURA, ERI ODA, SHINICHI AKAHOSHI, HIDEAKI YUKI, HIDEAKI MIYAMOTO, KOICHI DOI, TORU BEPPU
Anticancer Research Nov 2021, 41 (11) 5855-5861; DOI: 10.21873/anticanres.15405

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Far-advanced Colorectal Liver Metastases Successfully Managed With Modified ALPPS and Radiofrequency Ablation in Combination With Chemotherapy
YUKI ADACHI, KENSUKE YAMAMURA, SHINSEI YUMOTO, TAKAAKI HIGASHI, HIROYUKI ISHIODORI, SHINOBU HONDA, YOSHIHIRO HARA, KAZUKI MATSUMURA, ERI ODA, SHINICHI AKAHOSHI, HIDEAKI YUKI, HIDEAKI MIYAMOTO, KOICHI DOI, TORU BEPPU
Anticancer Research Nov 2021, 41 (11) 5855-5861; DOI: 10.21873/anticanres.15405
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Keywords

  • Liver partition
  • portal vein ligation
  • staged hepatectomy
  • Colorectal liver metastases
  • multidisciplinary treatment
  • radiofrequency ablation
  • systemic chemotherapy
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