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Research ArticleClinical Studies

Radiation Pneumonitis After Volumetric Modulated Arc Therapy for Non-small Cell Lung Cancer

MASAYUKI FUJIWARA, HIROSHI DOI, MASATAKA IGETA, HITOMI SUZUKI, KAZUHIRO KITAJIMA, MASAO TANOOKA, TOSHIHISA ISHIDA, TSUKASA WAKAYAMA, TAKASHI YOKOI, KOZO KURIBAYASHI, TAKASHI KIJIMA, MASAKI HASHIMOTO, NOBUYUKI KONDO, SEIJI MATSUMOTO, SEIKI HASEGAWA, NORIHIKO KAMIKONYA and KOICHIRO YAMAKADO
Anticancer Research November 2021, 41 (11) 5793-5802; DOI: https://doi.org/10.21873/anticanres.15396
MASAYUKI FUJIWARA
1Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan;
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  • For correspondence: m-fuji@hyo-med.ac.jp
HIROSHI DOI
1Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan;
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MASATAKA IGETA
2Department of Biostatistics, Hyogo College of Medicine, Nishinomiya, Japan;
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HITOMI SUZUKI
1Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan;
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KAZUHIRO KITAJIMA
1Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan;
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MASAO TANOOKA
1Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan;
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TOSHIHISA ISHIDA
3Department of Radiological technology, Hyogo College of Medicine College Hospital, Nishinomiya, Japan;
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TSUKASA WAKAYAMA
3Department of Radiological technology, Hyogo College of Medicine College Hospital, Nishinomiya, Japan;
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TAKASHI YOKOI
4Department of Respiratory Medicine and Hematology, Hyogo College of Medicine, Nishinomiya, Japan;
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KOZO KURIBAYASHI
4Department of Respiratory Medicine and Hematology, Hyogo College of Medicine, Nishinomiya, Japan;
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TAKASHI KIJIMA
4Department of Respiratory Medicine and Hematology, Hyogo College of Medicine, Nishinomiya, Japan;
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MASAKI HASHIMOTO
5Department of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Japan
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NOBUYUKI KONDO
5Department of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Japan
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SEIJI MATSUMOTO
5Department of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Japan
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SEIKI HASEGAWA
5Department of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Japan
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NORIHIKO KAMIKONYA
1Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan;
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KOICHIRO YAMAKADO
1Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan;
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Abstract

Background/Aim: To evaluate the incidence and grade of radiation pneumonitis after volumetric modulated arc therapy (VMAT) performed for the treatment of non-small cell cancer (NSCLC). Patients and Methods: Fifty consecutive non-surgical candidates with NSCLC underwent VMAT. Thirty-five patients had stage-III tumors and 15 had recurrent tumors. The prescribed radiation dose for the gross tumor and the elective nodal area was 69 Gy in 30 fractions and 51 Gy in 30 fractions, respectively. Results: Radiation pneumonitis developed in 38 patients (76%, 38/50), and grade ≥2 radiation pneumonitis developed in 11 patients (22%, 11/50). The percentage of lung volume that received a dose in excess of 5 Gy (V5), V10, V20, V30, and the mean lung dose (MLD) in the bilateral and ipsilateral lung were significantly associated with the development of grade ≥2 radiation pneumonitis. Conclusion: The incidence and degree of radiation pneumonitis are acceptable following treatment of NSCLC with VMAT.

Key Words:
  • Non-small cell lung cancer
  • chemoradiotherapy
  • IMRT
  • VMAT
  • radiation pneumonitis
  • Received August 10, 2021.
  • Revision received September 11, 2021.
  • Accepted September 15, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (11)
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November 2021
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Radiation Pneumonitis After Volumetric Modulated Arc Therapy for Non-small Cell Lung Cancer
MASAYUKI FUJIWARA, HIROSHI DOI, MASATAKA IGETA, HITOMI SUZUKI, KAZUHIRO KITAJIMA, MASAO TANOOKA, TOSHIHISA ISHIDA, TSUKASA WAKAYAMA, TAKASHI YOKOI, KOZO KURIBAYASHI, TAKASHI KIJIMA, MASAKI HASHIMOTO, NOBUYUKI KONDO, SEIJI MATSUMOTO, SEIKI HASEGAWA, NORIHIKO KAMIKONYA, KOICHIRO YAMAKADO
Anticancer Research Nov 2021, 41 (11) 5793-5802; DOI: 10.21873/anticanres.15396

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Radiation Pneumonitis After Volumetric Modulated Arc Therapy for Non-small Cell Lung Cancer
MASAYUKI FUJIWARA, HIROSHI DOI, MASATAKA IGETA, HITOMI SUZUKI, KAZUHIRO KITAJIMA, MASAO TANOOKA, TOSHIHISA ISHIDA, TSUKASA WAKAYAMA, TAKASHI YOKOI, KOZO KURIBAYASHI, TAKASHI KIJIMA, MASAKI HASHIMOTO, NOBUYUKI KONDO, SEIJI MATSUMOTO, SEIKI HASEGAWA, NORIHIKO KAMIKONYA, KOICHIRO YAMAKADO
Anticancer Research Nov 2021, 41 (11) 5793-5802; DOI: 10.21873/anticanres.15396
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Keywords

  • Non-small cell lung cancer
  • chemoradiotherapy
  • IMRT
  • VMAT
  • Radiation pneumonitis
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