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Research ArticleClinical Studies

Impact of Sarcopenia as a Prognostic Factor on Reductive Hepatectomy for Advanced Hepatocellular Carcinoma

SATOSHI OMIYA, SHOHEI KOMATSU, MASAHIRO KIDO, KAORI KURAMITSU, HIDETOSHI GON, KENJI FUKUSHIMA, TAKESHI URADE, SHINICHI SO, KEITARO SOFUE, YOSHIHIKO YANO, YOSHITADA SAKAI, HIROAKI YANAGIMOTO, HIROCHIKA TOYAMA, TETSUO AJIKI and TAKUMI FUKUMOTO
Anticancer Research November 2021, 41 (11) 5775-5783; DOI: https://doi.org/10.21873/anticanres.15394
SATOSHI OMIYA
1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
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SHOHEI KOMATSU
1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
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  • For correspondence: komasho8@med.kobe-u.ac.jp
MASAHIRO KIDO
1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
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KAORI KURAMITSU
1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
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HIDETOSHI GON
1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
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KENJI FUKUSHIMA
1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
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TAKESHI URADE
1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
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SHINICHI SO
1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
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KEITARO SOFUE
2Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan;
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YOSHIHIKO YANO
3Department of Internal Medicine, Division of Gastroenterology, Kobe University Graduate School of Medicine, Kobe, Japan;
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YOSHITADA SAKAI
4Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
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HIROAKI YANAGIMOTO
1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
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HIROCHIKA TOYAMA
1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
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TETSUO AJIKI
1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
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TAKUMI FUKUMOTO
1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;
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Abstract

Background/Aim: Sarcopenia has been reported to be a significant prognostic factor in patients with hepatocellular carcinoma in recent years. This study aimed to clarify the prognostic significance of sarcopenia in advanced hepatocellular carcinoma treated with reductive hepatectomy. Patients and Methods: We retrospectively analyzed 93 patients who underwent reductive hepatectomy for advanced hepatocellular carcinoma. Results: Median survival time of the sarcopenia group (16.4 months) was significantly shorter than that of the non-sarcopenia group (20.4 months). The overall survival rates at 1, 3, and 5 years of the sarcopenia group were significantly lower than those of the non-sarcopenia group (57.9%, 8.6%, and 2.9% vs. 67.3%, 29.2%, and 15.7%, respectively; p=0.035). On multivariate analysis, sarcopenia was a significant risk factor of overall survival (hazard ratio=1.60, 95% confidence interval=1.00-2.56, p=0.049). Conclusion: Sarcopenia was a significant prognostic factor of survival after reductive hepatectomy in advanced hepatocellular carcinoma.

Key Words:
  • Sarcopenia
  • skeletal muscle index
  • reductive hepatectomy
  • advanced hepatocellular carcinoma
  • Received August 6, 2021.
  • Revision received September 19, 2021.
  • Accepted September 20, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (11)
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Impact of Sarcopenia as a Prognostic Factor on Reductive Hepatectomy for Advanced Hepatocellular Carcinoma
SATOSHI OMIYA, SHOHEI KOMATSU, MASAHIRO KIDO, KAORI KURAMITSU, HIDETOSHI GON, KENJI FUKUSHIMA, TAKESHI URADE, SHINICHI SO, KEITARO SOFUE, YOSHIHIKO YANO, YOSHITADA SAKAI, HIROAKI YANAGIMOTO, HIROCHIKA TOYAMA, TETSUO AJIKI, TAKUMI FUKUMOTO
Anticancer Research Nov 2021, 41 (11) 5775-5783; DOI: 10.21873/anticanres.15394

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Impact of Sarcopenia as a Prognostic Factor on Reductive Hepatectomy for Advanced Hepatocellular Carcinoma
SATOSHI OMIYA, SHOHEI KOMATSU, MASAHIRO KIDO, KAORI KURAMITSU, HIDETOSHI GON, KENJI FUKUSHIMA, TAKESHI URADE, SHINICHI SO, KEITARO SOFUE, YOSHIHIKO YANO, YOSHITADA SAKAI, HIROAKI YANAGIMOTO, HIROCHIKA TOYAMA, TETSUO AJIKI, TAKUMI FUKUMOTO
Anticancer Research Nov 2021, 41 (11) 5775-5783; DOI: 10.21873/anticanres.15394
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Keywords

  • sarcopenia
  • skeletal muscle index
  • reductive hepatectomy
  • advanced hepatocellular carcinoma
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