Research ArticleClinical Studies

Smoking History Predicts High Presence of TILs and Efficacy of PD-1 Blockade in PD-L1 Expression-negative Non-small Cell Lung Cancer Patients

YUKIKO SHIMODA, TATSUYA YOSHIDA, MASAYUKI SHIRASAWA, TAKAAKI MIZUNO, HITOMI JO, YUJI MATSUMOTO, YUKI SHINNO, YUSUKE OKUMA, YASUSHI GOTO, HIDEHITO HORINOUCHI, NOBORU YAMAMOTO, YASUSHI YATABE, YUICHIRO OHE and NORIKO MOTOI
Anticancer Research November 2021, 41 (11) 5739-5747; DOI: https://doi.org/10.21873/anticanres.15390

Article Information

vol. 41 no. 11 5739-5747
DOI 
https://doi.org/10.21873/anticanres.15390
PubMed 
34732447
Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received September 7, 2021
  • Revision received October 10, 2021
  • Accepted October 11, 2021
  • Published online November 3, 2021.
Copyright & Usage 
Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. YUKIKO SHIMODA1,2,
  2. TATSUYA YOSHIDA1,3⇑,
  3. MASAYUKI SHIRASAWA1,
  4. TAKAAKI MIZUNO1,
  5. HITOMI JO1,
  6. YUJI MATSUMOTO1,
  7. YUKI SHINNO1,
  8. YUSUKE OKUMA1,
  9. YASUSHI GOTO1,
  10. HIDEHITO HORINOUCHI1,
  11. NOBORU YAMAMOTO1,3,
  12. YASUSHI YATABE4,
  13. YUICHIRO OHE1,2 and
  14. NORIKO MOTOI4
  1. 1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
  2. 2Cancer Medicine, Cooperative Graduate School, The Jikei University Graduate School of Medicine, Tokyo, Japan;
  3. 3Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan;
  4. 4Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan
  1. Correspondence to: Tatsuya Yoshida, MD, Ph.D., Department of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo,104-0045, Japan. Tel: +81 335422511, Fax: +81 335423815, e-mail: tatyoshi{at}ncc.go.jp
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Smoking History Predicts High Presence of TILs and Efficacy of PD-1 Blockade in PD-L1 Expression-negative Non-small Cell Lung Cancer Patients
YUKIKO SHIMODA, TATSUYA YOSHIDA, MASAYUKI SHIRASAWA, TAKAAKI MIZUNO, HITOMI JO, YUJI MATSUMOTO, YUKI SHINNO, YUSUKE OKUMA, YASUSHI GOTO, HIDEHITO HORINOUCHI, NOBORU YAMAMOTO, YASUSHI YATABE, YUICHIRO OHE, NORIKO MOTOI
Anticancer Research Nov 2021, 41 (11) 5739-5747; DOI: 10.21873/anticanres.15390
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