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Research ArticleClinical Studies

Smoking History Predicts High Presence of TILs and Efficacy of PD-1 Blockade in PD-L1 Expression-negative Non-small Cell Lung Cancer Patients

YUKIKO SHIMODA, TATSUYA YOSHIDA, MASAYUKI SHIRASAWA, TAKAAKI MIZUNO, HITOMI JO, YUJI MATSUMOTO, YUKI SHINNO, YUSUKE OKUMA, YASUSHI GOTO, HIDEHITO HORINOUCHI, NOBORU YAMAMOTO, YASUSHI YATABE, YUICHIRO OHE and NORIKO MOTOI
Anticancer Research November 2021, 41 (11) 5739-5747; DOI: https://doi.org/10.21873/anticanres.15390
YUKIKO SHIMODA
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
2Cancer Medicine, Cooperative Graduate School, The Jikei University Graduate School of Medicine, Tokyo, Japan;
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TATSUYA YOSHIDA
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
3Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan;
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  • For correspondence: tatyoshi@ncc.go.jp
MASAYUKI SHIRASAWA
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
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TAKAAKI MIZUNO
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
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HITOMI JO
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
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YUJI MATSUMOTO
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
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YUKI SHINNO
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
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YUSUKE OKUMA
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
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YASUSHI GOTO
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
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HIDEHITO HORINOUCHI
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
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NOBORU YAMAMOTO
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
3Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan;
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YASUSHI YATABE
4Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan
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YUICHIRO OHE
1Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan;
2Cancer Medicine, Cooperative Graduate School, The Jikei University Graduate School of Medicine, Tokyo, Japan;
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NORIKO MOTOI
4Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan
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Anticancer Research: 41 (11)
Anticancer Research
Vol. 41, Issue 11
November 2021
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Smoking History Predicts High Presence of TILs and Efficacy of PD-1 Blockade in PD-L1 Expression-negative Non-small Cell Lung Cancer Patients
YUKIKO SHIMODA, TATSUYA YOSHIDA, MASAYUKI SHIRASAWA, TAKAAKI MIZUNO, HITOMI JO, YUJI MATSUMOTO, YUKI SHINNO, YUSUKE OKUMA, YASUSHI GOTO, HIDEHITO HORINOUCHI, NOBORU YAMAMOTO, YASUSHI YATABE, YUICHIRO OHE, NORIKO MOTOI
Anticancer Research Nov 2021, 41 (11) 5739-5747; DOI: 10.21873/anticanres.15390

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Smoking History Predicts High Presence of TILs and Efficacy of PD-1 Blockade in PD-L1 Expression-negative Non-small Cell Lung Cancer Patients
YUKIKO SHIMODA, TATSUYA YOSHIDA, MASAYUKI SHIRASAWA, TAKAAKI MIZUNO, HITOMI JO, YUJI MATSUMOTO, YUKI SHINNO, YUSUKE OKUMA, YASUSHI GOTO, HIDEHITO HORINOUCHI, NOBORU YAMAMOTO, YASUSHI YATABE, YUICHIRO OHE, NORIKO MOTOI
Anticancer Research Nov 2021, 41 (11) 5739-5747; DOI: 10.21873/anticanres.15390
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Keywords

  • Non-small cell lung cancer (NSCLC)
  • programmed death-ligand 1 (PD-L1)
  • smoking index
  • nivolumab
  • CD8+ tumor infiltrating lymphocytes (TILs)
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