Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

Clinical Impact of Primary Tumor Site in Stage IV Colorectal Cancer: A Statewide Cohort Study

HIDETAKA KAWAMURA, MICHITAKA HONDA, KOICHI TAKIGUCHI, TAKAHIRO KAMIGA, KATSUMASA SAITO, ATSUSHI MUTO, SATORU SHIRASO, NAOYUKI YAMASHITA, TOSHIYASU IWAO, SHIGEHIRA SAJI, KOJI KONO and SHINICHI KONNO
Anticancer Research November 2021, 41 (11) 5693-5702; DOI: https://doi.org/10.21873/anticanres.15385
HIDETAKA KAWAMURA
1Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan;
2Department of Surgical Oncology, Southern Tohoku General Hospital, Southern Tohoku Research Institute for Neuroscience, Koriyama, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: hidetaka0716.hk@gmail.com
MICHITAKA HONDA
1Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan;
2Department of Surgical Oncology, Southern Tohoku General Hospital, Southern Tohoku Research Institute for Neuroscience, Koriyama, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KOICHI TAKIGUCHI
3Department of Surgery, The Takeda Healthcare Foundation Takeda General Hospital, Aizu-Wakamatsu, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
TAKAHIRO KAMIGA
4Department of Surgery, Shirakawa Kosei General Hospital, Shirakawa, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KATSUMASA SAITO
5Department of Surgery, Ohta Nishinouchi Hospital, Koriyama, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ATSUSHI MUTO
6Department of Surgery, Fukishma Rosai Hospital, Iwaki, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SATORU SHIRASO
7Department of Surgery, Iwaki Kyoritsu General Hospital, Iwaki, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
NAOYUKI YAMASHITA
8Department of Surgery, Tsuboi Hospital, Koriyama, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
TOSHIYASU IWAO
9Department of Gastroenterology, Aidu Chuo Hospital, Aizu-Wakamatsu, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SHIGEHIRA SAJI
10Department of Medical Oncology, Fukushima Medical University, Fukushima, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KOJI KONO
11Department of Gastrointestinal Tract Surgery, Fukushima Medical University, Fukushima, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SHINICHI KONNO
12Department of Orthopedic Surgery, Fukushima Medical University, Fukushima, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Background/Aim: We investigated the clinical impact of the primary tumor site in stage IV colorectal cancer (CRC). Patients and Methods: In this statewide multicenter retrospective cohort, patients with stage IV CRC from nine hospital-based cancer registries across the Fukushima Prefecture (2008-2015) were categorized based on three primary tumor sites: right colon cancer (RCC), left colon cancer (LCC), and rectal cancer. Overall survival was assessed using Cox regression analysis. Results: A total of 1,211 patients were included. The most common clinical symptom was obstruction in LCC and bleeding in rectal cancer. Liver metastases were multiple and larger in LCC, while lung metastases were multiple in rectal cancer. Compared to LCC, the adjusted hazard ratio (HR) for overall survival was 1.19 [95% confidence interval (CI)=1.01-1.39, p=0.032] in RCC and 1.03 (95% CI=0.86-1.23, p=0.77) in rectal cancer. Conclusion: RCC was independently associated with a worse prognosis in stage IV CRC.

Key Words:
  • Primary tumor site
  • colorectal neoplasms
  • population-based study
  • observational study
  • survival analysis
  • Received August 5, 2021.
  • Revision received September 7, 2021.
  • Accepted September 23, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
View Full Text

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.

patientACCESS

patientACCESS - Patients desiring access to articles
PreviousNext
Back to top

In this issue

Anticancer Research: 41 (11)
Anticancer Research
Vol. 41, Issue 11
November 2021
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Clinical Impact of Primary Tumor Site in Stage IV Colorectal Cancer: A Statewide Cohort Study
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
1 + 14 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Clinical Impact of Primary Tumor Site in Stage IV Colorectal Cancer: A Statewide Cohort Study
HIDETAKA KAWAMURA, MICHITAKA HONDA, KOICHI TAKIGUCHI, TAKAHIRO KAMIGA, KATSUMASA SAITO, ATSUSHI MUTO, SATORU SHIRASO, NAOYUKI YAMASHITA, TOSHIYASU IWAO, SHIGEHIRA SAJI, KOJI KONO, SHINICHI KONNO
Anticancer Research Nov 2021, 41 (11) 5693-5702; DOI: 10.21873/anticanres.15385

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Clinical Impact of Primary Tumor Site in Stage IV Colorectal Cancer: A Statewide Cohort Study
HIDETAKA KAWAMURA, MICHITAKA HONDA, KOICHI TAKIGUCHI, TAKAHIRO KAMIGA, KATSUMASA SAITO, ATSUSHI MUTO, SATORU SHIRASO, NAOYUKI YAMASHITA, TOSHIYASU IWAO, SHIGEHIRA SAJI, KOJI KONO, SHINICHI KONNO
Anticancer Research Nov 2021, 41 (11) 5693-5702; DOI: 10.21873/anticanres.15385
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Patients and Methods
    • Results
    • Discussion
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Pelvic Recurrence After Curative Resection for Rectal Adenocarcinoma: Impact of Surgery on Survival
  • Glasgow Prognostic Score Predicts Survival and Recurrence Pattern in Patients With Hepatocellular Carcinoma After Hepatectomy
  • Small Bowel Lipomatosis: An Unusual Radiological Finding in Patients With Renal Cell Cancer on Pazopanib
Show more Clinical Studies

Similar Articles

Keywords

  • Primary tumor site
  • colorectal neoplasms
  • population-based study
  • observational study
  • survival analysis
Anticancer Research

© 2023 Anticancer Research

Powered by HighWire