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Research ArticleClinical Studies

Impact of Intraoperative Blood Loss and Blood Transfusion on the Prognosis of Colorectal Liver Metastasis Following Curative Resection

SHIBUTANI MASATSUNE, KENJIRO KIMURA, SHINICHIRO KASHIWAGI, WANG EN, YUKI OKAZAKI, KIYOSHI MAEDA, KOSEI HIRAKAWA and MASAICHI OHIRA
Anticancer Research November 2021, 41 (11) 5617-5623; DOI: https://doi.org/10.21873/anticanres.15377
SHIBUTANI MASATSUNE
1Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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  • For correspondence: fbxbj429@ybb.ne.jp
KENJIRO KIMURA
2Department of Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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SHINICHIRO KASHIWAGI
3Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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WANG EN
1Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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YUKI OKAZAKI
1Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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KIYOSHI MAEDA
1Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
4Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
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KOSEI HIRAKAWA
1Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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MASAICHI OHIRA
1Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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Abstract

Background/Aim: The identification of risk factors for recurrence after resection of colorectal liver metastasis is necessary in order to establish a more effective treatment strategy. In addition to well-known prognostic factors, such as the tumor diameter and number of metastatic tumors, a large amount of intraoperative blood loss (IBL) and blood transfusion have recently been reported to be associated with shorter long-term survival. The aim of this study was to assess the impact of IBL and blood transfusion on the prognosis of colorectal liver metastasis after curative resection. Patients and Methods: A total of 104 patients who underwent R0 resection for colorectal liver metastasis were enrolled in this study. Results: The high-IBL (>300 ml) group had significantly shorter relapse-free survival after hepatic resection in comparison to the low-IBL (≤300 ml) group (p=0.0025). Patients with blood transfusion had significantly shorter relapse-free survival after hepatic resection in comparison to patients without blood transfusion (p=0.0026). Conclusion: A large amount of IBL and blood transfusion may have a negative impact on long-term survival in patients who undergo hepatic resection for colorectal liver metastasis.

Key Words:
  • Colorectal liver metastasis
  • prognosis
  • blood transfusion
  • intraoperative blood loss
  • Received September 1, 2021.
  • Revision received September 13, 2021.
  • Accepted September 15, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (11)
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November 2021
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Impact of Intraoperative Blood Loss and Blood Transfusion on the Prognosis of Colorectal Liver Metastasis Following Curative Resection
SHIBUTANI MASATSUNE, KENJIRO KIMURA, SHINICHIRO KASHIWAGI, WANG EN, YUKI OKAZAKI, KIYOSHI MAEDA, KOSEI HIRAKAWA, MASAICHI OHIRA
Anticancer Research Nov 2021, 41 (11) 5617-5623; DOI: 10.21873/anticanres.15377

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Impact of Intraoperative Blood Loss and Blood Transfusion on the Prognosis of Colorectal Liver Metastasis Following Curative Resection
SHIBUTANI MASATSUNE, KENJIRO KIMURA, SHINICHIRO KASHIWAGI, WANG EN, YUKI OKAZAKI, KIYOSHI MAEDA, KOSEI HIRAKAWA, MASAICHI OHIRA
Anticancer Research Nov 2021, 41 (11) 5617-5623; DOI: 10.21873/anticanres.15377
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Keywords

  • Colorectal liver metastasis
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