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Research ArticleClinical Studies

Brain Metastasis in Soft Tissue Sarcoma at Initial Presentation

RYO ITOGA, MASATAKE MATSUOKA, TOMOHIRO ONODERA, ISAO YOKOTA, KOJI IWASAKI, SHINJI MATSUBARA, RYOSUKE HISHIMURA, YUKI SUZUKI, AKIRA IWATA, EIJI KONDO and NORIMASA IWASAKI
Anticancer Research November 2021, 41 (11) 5611-5616; DOI: https://doi.org/10.21873/anticanres.15376
RYO ITOGA
1Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan;
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MASATAKE MATSUOKA
1Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan;
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  • For correspondence: masatakem@pop.med.hokudai.ac.jp
TOMOHIRO ONODERA
1Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan;
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ISAO YOKOTA
2Department of Biostatistics, Graduate School of Medicine, Hokkaido University, Sapporo, Japan;
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KOJI IWASAKI
3Department of Functional Reconstruction for the Knee Joint, Hokkaido University, Sapporo, Japan;
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SHINJI MATSUBARA
1Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan;
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RYOSUKE HISHIMURA
1Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan;
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YUKI SUZUKI
1Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan;
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AKIRA IWATA
1Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan;
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EIJI KONDO
4Centre for Sports Medicine, Hokkaido University Hospital, Sapporo, Japan
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NORIMASA IWASAKI
1Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan;
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Abstract

Background/Aim: Brain metastasis is a rare condition among patients with soft tissue sarcoma (STS), and its precise incidence remains unclear. The aim of this study was to investigate which patients should be screened for brain metastasis. Patients and Methods: We identified all patients with STS diagnosed between 2010 and 2015 in the SEER database. Incidence of brain metastasis at initial presentation and higher incidence of brain metastasis by histological subtype were investigated. In addition, risk factors for brain metastasis were examined. Results: A total of 26,676 patients were included for analysis, of whom 162 patients (0.6%) had brain metastasis. Alveolar soft part sarcoma (6.3%), malignant hemangioendothelioma (3.1%) and malignant schwannoma (2.6%) showed higher incidence of brain metastasis. Deep-rooted tumor, trunk tumor, and histological high-grade tumor tended to show higher incidence of brain metastasis. Conclusion: Risk factors for brain metastasis were deep location, trunk development and histologically high-grade tumor, or specific histological subtypes.

Key Words:
  • Soft tissue sarcoma
  • brain metastasis
  • mortality
  • secondary surgery
  • soft tissue sarcoma
  • SEER program
  • neoplasm grading
  • retrospective study
  • treatment outcome
  • Received August 14, 2021.
  • Revision received September 10, 2021.
  • Accepted September 29, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (11)
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Brain Metastasis in Soft Tissue Sarcoma at Initial Presentation
RYO ITOGA, MASATAKE MATSUOKA, TOMOHIRO ONODERA, ISAO YOKOTA, KOJI IWASAKI, SHINJI MATSUBARA, RYOSUKE HISHIMURA, YUKI SUZUKI, AKIRA IWATA, EIJI KONDO, NORIMASA IWASAKI
Anticancer Research Nov 2021, 41 (11) 5611-5616; DOI: 10.21873/anticanres.15376

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Brain Metastasis in Soft Tissue Sarcoma at Initial Presentation
RYO ITOGA, MASATAKE MATSUOKA, TOMOHIRO ONODERA, ISAO YOKOTA, KOJI IWASAKI, SHINJI MATSUBARA, RYOSUKE HISHIMURA, YUKI SUZUKI, AKIRA IWATA, EIJI KONDO, NORIMASA IWASAKI
Anticancer Research Nov 2021, 41 (11) 5611-5616; DOI: 10.21873/anticanres.15376
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Keywords

  • soft tissue sarcoma
  • brain metastasis
  • mortality
  • secondary surgery
  • SEER program
  • neoplasm grading
  • retrospective study
  • treatment outcome
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