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Research ArticleClinical Studies

Safety and Feasibility of Gastrectomy for Gastric Cancer in Patients Receiving Antiplatelet and/or Anticoagulation Treatment

TORU AOYAMA, MASATO NAKAZONO, KENKI SEGAMI, SHINSUKE NAGASAWA, KENTARO HARA, HIROSHI TAMAGAWA, KEISUKE KOMORI, HIDEAKI SUEMATSU, YUKIO MAEZAWA, KAZUKI KANO, ITARU HASHIMOTO, TAKAONOBU YAMADA, TSUTOMU SATO, MASAKATSU NUMATA, NORIO YUKAWA, TAKASHI OGATA, YASUSHI RINO and TAKASHI OSHIMA
Anticancer Research November 2021, 41 (11) 5605-5610; DOI: https://doi.org/10.21873/anticanres.15375
TORU AOYAMA
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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  • For correspondence: t-aoyama@lilac.plala.or.jp oshimat@kcch.jp
MASATO NAKAZONO
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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KENKI SEGAMI
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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SHINSUKE NAGASAWA
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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KENTARO HARA
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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HIROSHI TAMAGAWA
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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KEISUKE KOMORI
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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HIDEAKI SUEMATSU
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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YUKIO MAEZAWA
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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KAZUKI KANO
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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ITARU HASHIMOTO
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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TAKAONOBU YAMADA
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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TSUTOMU SATO
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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MASAKATSU NUMATA
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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NORIO YUKAWA
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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TAKASHI OGATA
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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YASUSHI RINO
1Department of Surgery, Yokohama City University, Yokohama, Japan;
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TAKASHI OSHIMA
1Department of Surgery, Yokohama City University, Yokohama, Japan;
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
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  • For correspondence: t-aoyama@lilac.plala.or.jp oshimat@kcch.jp
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Abstract

Background/Aim: The number of patients who have cardiovascular-morbidities and use antiplatelet and/or anticoagulation therapy is rapidly growing worldwide. The present study evaluated the safety and feasibility of gastrectomy for gastric cancer in patients who received antiplatelet and/or anticoagulation therapy in the perioperative period. Patients and Methods: Cases were selected from the medical records of consecutive patients who were diagnosed with gastric cancer and underwent complete resection at the Kanagawa Cancer Center from 2013 to 2017. The patients were divided into the antiplatelet and/or anticoagulation treatment group and the non-antiplatelet and/or anticoagulation treatment group. Results: Five hundred and six patients underwent gastrectomy for gastric cancer and were analyzed in the present study. Among them, 62 patients (12.3%) received anticoagulation therapy (anticoagulation group). When the anticoagulation and non-anticoagulation groups were compared, although there were some differences in patient background factors, the surgical findings, perioperative clinical course, and details of postoperative complications were similar. The incidence of postoperative bleeding was 0.8% (4/506) in all patients. The incidence of postoperative bleeding was 1.6% (1/62) in the anticoagulation group and 0.7% (3/446) in the non-anticoagulation group. Preoperative anticoagulation therapy was not identified as a significant independent risk factor for postoperative bleeding. Conclusion: These results suggest that curative gastrectomy for gastric cancer is safe and feasible, regardless of the perioperative use of antiplatelet and/or anticoagulation treatment. In addition, the perioperative use of antiplatelet and/or anticoagulation treatment was not a significant risk factor for postoperative bleeding after gastrectomy for gastric cancer.

Key Words:
  • Gastric cancer
  • bleeding
  • antiplatelet treatment
  • anticoagulation treatment
  • Received September 13, 2021.
  • Revision received September 23, 2021.
  • Accepted October 13, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (11)
Anticancer Research
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November 2021
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Safety and Feasibility of Gastrectomy for Gastric Cancer in Patients Receiving Antiplatelet and/or Anticoagulation Treatment
TORU AOYAMA, MASATO NAKAZONO, KENKI SEGAMI, SHINSUKE NAGASAWA, KENTARO HARA, HIROSHI TAMAGAWA, KEISUKE KOMORI, HIDEAKI SUEMATSU, YUKIO MAEZAWA, KAZUKI KANO, ITARU HASHIMOTO, TAKAONOBU YAMADA, TSUTOMU SATO, MASAKATSU NUMATA, NORIO YUKAWA, TAKASHI OGATA, YASUSHI RINO, TAKASHI OSHIMA
Anticancer Research Nov 2021, 41 (11) 5605-5610; DOI: 10.21873/anticanres.15375

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Safety and Feasibility of Gastrectomy for Gastric Cancer in Patients Receiving Antiplatelet and/or Anticoagulation Treatment
TORU AOYAMA, MASATO NAKAZONO, KENKI SEGAMI, SHINSUKE NAGASAWA, KENTARO HARA, HIROSHI TAMAGAWA, KEISUKE KOMORI, HIDEAKI SUEMATSU, YUKIO MAEZAWA, KAZUKI KANO, ITARU HASHIMOTO, TAKAONOBU YAMADA, TSUTOMU SATO, MASAKATSU NUMATA, NORIO YUKAWA, TAKASHI OGATA, YASUSHI RINO, TAKASHI OSHIMA
Anticancer Research Nov 2021, 41 (11) 5605-5610; DOI: 10.21873/anticanres.15375
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Keywords

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