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Research ArticleClinical Studies

Lung Cancer in Non-smokers in Czech Republic: Data from LUCAS Lung Cancer Clinical Registry

ONDREJ VENCLICEK, JANA SKRICKOVA, KRISTIAN BRAT, ONDREJ FISCHER, LIBOR HAVEL, MICHAL HRNCIARIK, MILOSLAV MAREL, PETR OPALKA, GABRIELA KRAKOROVA, DENISA ROZSIVALOVA, JURAJ KULTAN, ANDREA MULLEROVA, LYDIA ZARNAYOVA, PETRA SMICKOVA, MARTINA VASAKOVA, ZSUZSANNA GYORFY, MICHAL JIROUSEK, DANIEL KREJCI, JANA KREJCI, PETR ZUNA, MARTIN SVATON, KRISTYNA HRDA, JAROSLAV DUBA, JANA ALAHAKOON, MICHAL SVOBODA and JIRI SILAR
Anticancer Research November 2021, 41 (11) 5549-5556; DOI: https://doi.org/10.21873/anticanres.15368
ONDREJ VENCLICEK
1Department of Respiratory Diseases, University Hospital Brno, Brno, Czech Republic;
2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
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  • For correspondence: venclicek.ondrej@fnbrno.cz
JANA SKRICKOVA
1Department of Respiratory Diseases, University Hospital Brno, Brno, Czech Republic;
2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
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KRISTIAN BRAT
1Department of Respiratory Diseases, University Hospital Brno, Brno, Czech Republic;
2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
3International Clinical Research Center, St. Anne’s University Hospital, Brno, Czech Republic;
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ONDREJ FISCHER
4Department of Respiratory Medicine, University Hospital Olomouc, Olomouc, Czech Republic;
5Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;
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LIBOR HAVEL
6Department of Respiratory Medicine, Thomayer Hospital, Prague, Czech Republic;
71st Faculty of Medicine, Charles University, Prague, Czech Republic;
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MICHAL HRNCIARIK
8Pulmonary Department, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic;
9Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic;
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MILOSLAV MAREL
10Department of Pulmonology, University Hospital Motol, Prague, Czech Republic;
112nd Faculty of Medicine, Charles University, Prague, Czech Republic;
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PETR OPALKA
12Department of Pneumology, Bulovka University Hospital, Prague, Czech Republic;
133rd Faculty of Medicine, Charles University, Prague, Czech Republic;
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GABRIELA KRAKOROVA
12Department of Pneumology, Bulovka University Hospital, Prague, Czech Republic;
133rd Faculty of Medicine, Charles University, Prague, Czech Republic;
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DENISA ROZSIVALOVA
4Department of Respiratory Medicine, University Hospital Olomouc, Olomouc, Czech Republic;
5Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;
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JURAJ KULTAN
4Department of Respiratory Medicine, University Hospital Olomouc, Olomouc, Czech Republic;
5Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;
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ANDREA MULLEROVA
4Department of Respiratory Medicine, University Hospital Olomouc, Olomouc, Czech Republic;
5Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;
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LYDIA ZARNAYOVA
4Department of Respiratory Medicine, University Hospital Olomouc, Olomouc, Czech Republic;
5Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;
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PETRA SMICKOVA
4Department of Respiratory Medicine, University Hospital Olomouc, Olomouc, Czech Republic;
5Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;
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MARTINA VASAKOVA
6Department of Respiratory Medicine, Thomayer Hospital, Prague, Czech Republic;
71st Faculty of Medicine, Charles University, Prague, Czech Republic;
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ZSUZSANNA GYORFY
6Department of Respiratory Medicine, Thomayer Hospital, Prague, Czech Republic;
71st Faculty of Medicine, Charles University, Prague, Czech Republic;
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MICHAL JIROUSEK
8Pulmonary Department, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic;
9Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic;
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DANIEL KREJCI
12Department of Pneumology, Bulovka University Hospital, Prague, Czech Republic;
133rd Faculty of Medicine, Charles University, Prague, Czech Republic;
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JANA KREJCI
12Department of Pneumology, Bulovka University Hospital, Prague, Czech Republic;
133rd Faculty of Medicine, Charles University, Prague, Czech Republic;
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PETR ZUNA
12Department of Pneumology, Bulovka University Hospital, Prague, Czech Republic;
133rd Faculty of Medicine, Charles University, Prague, Czech Republic;
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MARTIN SVATON
14Department of Pneumology, University Hospital Pilsen, Pilsen, Czech Republic;
15Faculty of Μedicine in Pilsen, Charles University, Pilsen, Czech Republic;
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KRISTYNA HRDA
14Department of Pneumology, University Hospital Pilsen, Pilsen, Czech Republic;
15Faculty of Μedicine in Pilsen, Charles University, Pilsen, Czech Republic;
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JAROSLAV DUBA
16OAKS Consulting, Prague, Czech Republic;
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JANA ALAHAKOON
16OAKS Consulting, Prague, Czech Republic;
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MICHAL SVOBODA
2Faculty of Medicine, Masaryk University, Brno, Czech Republic;
17Institute of Biostatistics and Analyses, Ltd., Brno, Czech Republic
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JIRI SILAR
17Institute of Biostatistics and Analyses, Ltd., Brno, Czech Republic
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Abstract

Background/Aim: LUCAS is a clinical lung cancer registry (ClinicalTrials.gov identifier is NCT04228237), prospectively collecting data from newly diagnosed lung cancer patients in seven pneumooncology centers in the Czech Republic, since June 1, 2018. The aim of the study was to assess the stage of the disease at the time of diagnosis, percentage of morphological types, survival, percentage of driving mutations, eligibility for radical surgery, and percentage of patients who undergo radical surgery, in the non-smoking population in comparison with smokers and former smokers. Patients and Methods: The total number of patients in the registry at the time of the analysis was 2,743. Only 2,439 patients with complete records (smoking status, stage, and type of tumor) were included in this study. Results: The analysis indicated that non-smokers are diagnosed at a later stage of the disease but they have a better survival rate than smokers. Fewer smokers with stage III disease who are eligible for radical surgery will undergo surgery compared to non-smokers with the same clinical stage. Driving mutations are more common in non-smokers, even after adjustment for the more frequent occurrence of adenocarcinoma in the group of non-smokers. Conclusion: The data from LUCAS registry are consistent with already known facts, suggesting that the LUCAS registry is a useful clinical tool.

Key Words:
  • Lung cancer
  • non-smokers
  • clinical registry
  • NSCLC
  • survival
  • driving mutations
  • Received August 30, 2021.
  • Revision received October 15, 2021.
  • Accepted October 18, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Lung Cancer in Non-smokers in Czech Republic: Data from LUCAS Lung Cancer Clinical Registry
ONDREJ VENCLICEK, JANA SKRICKOVA, KRISTIAN BRAT, ONDREJ FISCHER, LIBOR HAVEL, MICHAL HRNCIARIK, MILOSLAV MAREL, PETR OPALKA, GABRIELA KRAKOROVA, DENISA ROZSIVALOVA, JURAJ KULTAN, ANDREA MULLEROVA, LYDIA ZARNAYOVA, PETRA SMICKOVA, MARTINA VASAKOVA, ZSUZSANNA GYORFY, MICHAL JIROUSEK, DANIEL KREJCI, JANA KREJCI, PETR ZUNA, MARTIN SVATON, KRISTYNA HRDA, JAROSLAV DUBA, JANA ALAHAKOON, MICHAL SVOBODA, JIRI SILAR
Anticancer Research Nov 2021, 41 (11) 5549-5556; DOI: 10.21873/anticanres.15368

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Lung Cancer in Non-smokers in Czech Republic: Data from LUCAS Lung Cancer Clinical Registry
ONDREJ VENCLICEK, JANA SKRICKOVA, KRISTIAN BRAT, ONDREJ FISCHER, LIBOR HAVEL, MICHAL HRNCIARIK, MILOSLAV MAREL, PETR OPALKA, GABRIELA KRAKOROVA, DENISA ROZSIVALOVA, JURAJ KULTAN, ANDREA MULLEROVA, LYDIA ZARNAYOVA, PETRA SMICKOVA, MARTINA VASAKOVA, ZSUZSANNA GYORFY, MICHAL JIROUSEK, DANIEL KREJCI, JANA KREJCI, PETR ZUNA, MARTIN SVATON, KRISTYNA HRDA, JAROSLAV DUBA, JANA ALAHAKOON, MICHAL SVOBODA, JIRI SILAR
Anticancer Research Nov 2021, 41 (11) 5549-5556; DOI: 10.21873/anticanres.15368
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Keywords

  • Lung cancer
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