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Research ArticleExperimental Studies

Positive Correlation Between the Number of Circulating Tumor Cells in the Pulmonary Vein and Tumor Spread Through Air Spaces in Resected Non-small Cell Lung Cancer

HIROAKI KURODA, KATSUHIRO MASAGO, YUSUKE TAKAHASHI, SHIRO FUJITA, EIICHI SASAKI, TAKEO NAKADA, NORIAKI SAKAKURA, HAYAO NAKANISHI, HIROKAZU MATSUSHITA and YASUSHI YATABE
Anticancer Research November 2021, 41 (11) 5499-5505; DOI: https://doi.org/10.21873/anticanres.15363
HIROAKI KURODA
1Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan;
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  • For correspondence: h-kuroda@aichi-cc.jp
KATSUHIRO MASAGO
2Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan;
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YUSUKE TAKAHASHI
1Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan;
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SHIRO FUJITA
2Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan;
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EIICHI SASAKI
2Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan;
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TAKEO NAKADA
1Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan;
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NORIAKI SAKAKURA
1Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan;
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HAYAO NAKANISHI
2Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan;
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HIROKAZU MATSUSHITA
3Division of Translational Oncoimmunology, Aichi Cancer Research Institute, Nagoya, Japan;
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YASUSHI YATABE
2Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan;
4Department of Diagnostic Pathology, Division of Molecular Pathology, National Cancer Center, Tokyo, Japan
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Abstract

Background/Aim: Circulating tumor cells (CTCs) is one of the promising markers that predict dissemination and metastases. This study aimed to identify the relationship between CTCs in pulmonary vein (PuV) and spread through air space (STAS) in non-small cell lung cancers. Materials and Methods: We applied a cytology-based microfluidic platform for rare cell isolation. Twenty-four patients were enrolled. Results: The rate of CTC detection in PuV was 79.2%, and STAS was observed in 54.2% of the samples. When the definitive cut-off value was 1 CTC/1 ml, of the 14 CTC-PuV-high cases, 11 (78.6%) were STAS-positive, whereas 2 of the 10 (20.0%) CTC-PuV-low cases were STAS-positive, and the difference between the two groups was statistically significant (p=0.02). CTC-PuV-high exhibited a significantly poorer survival (p<0.01). Conclusion: The higher frequency of STAS is significantly associated with a higher number of CTCs in PuV, and the combination of STAS and CTC was significantly associated with poor prognosis.

Key Words:
  • Circulating tumor cells
  • non-small cell lung cancer
  • spread through air spaces
  • pulmonary vein
  • Received July 6, 2021.
  • Revision received October 17, 2021.
  • Accepted October 20, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (11)
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November 2021
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Positive Correlation Between the Number of Circulating Tumor Cells in the Pulmonary Vein and Tumor Spread Through Air Spaces in Resected Non-small Cell Lung Cancer
HIROAKI KURODA, KATSUHIRO MASAGO, YUSUKE TAKAHASHI, SHIRO FUJITA, EIICHI SASAKI, TAKEO NAKADA, NORIAKI SAKAKURA, HAYAO NAKANISHI, HIROKAZU MATSUSHITA, YASUSHI YATABE
Anticancer Research Nov 2021, 41 (11) 5499-5505; DOI: 10.21873/anticanres.15363

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Positive Correlation Between the Number of Circulating Tumor Cells in the Pulmonary Vein and Tumor Spread Through Air Spaces in Resected Non-small Cell Lung Cancer
HIROAKI KURODA, KATSUHIRO MASAGO, YUSUKE TAKAHASHI, SHIRO FUJITA, EIICHI SASAKI, TAKEO NAKADA, NORIAKI SAKAKURA, HAYAO NAKANISHI, HIROKAZU MATSUSHITA, YASUSHI YATABE
Anticancer Research Nov 2021, 41 (11) 5499-5505; DOI: 10.21873/anticanres.15363
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Keywords

  • Circulating tumor cells
  • non-small cell lung cancer
  • spread through air spaces
  • pulmonary vein
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