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Research ArticleExperimental Studies

Ideal Nozzle Position During Pressurized Intraperitoneal Aerosol Chemotherapy in an Ex Vivo Model

JINLAN PIAO, SOO JIN PARK, HEESU LEE, JUNSIK KIM, SUNWOO PARK, NARA LEE, SE IK KIM, MARIA LEE, GWONHWA SONG, JUNG CHAN LEE, HEE SEUNG KIM and ON BEHALF OF THE KORIA TRIAL GROUP
Anticancer Research November 2021, 41 (11) 5489-5498; DOI: https://doi.org/10.21873/anticanres.15362
JINLAN PIAO
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea;
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SOO JIN PARK
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea;
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HEESU LEE
2Interdisciplinary Program in Bioengineering, Seoul National University Graduate School, Seoul, Republic of Korea;
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JUNSIK KIM
2Interdisciplinary Program in Bioengineering, Seoul National University Graduate School, Seoul, Republic of Korea;
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SUNWOO PARK
3Department of Plant & Biomaterials Science, Gyeongsang National University, Jinju-si, Republic of Korea;
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NARA LEE
4Department of Obstetrics & Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea;
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SE IK KIM
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea;
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MARIA LEE
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea;
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GWONHWA SONG
5Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea;
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JUNG CHAN LEE
6Department of Biomedical Engineering, Seoul National University College of Medicine, and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, Republic of Korea
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HEE SEUNG KIM
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea;
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  • For correspondence: bboddi0311@gmail.com
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Abstract

Background/Aim: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is known to show uneven distribution and penetration of agents based on the nozzle position. Thus, this study aimed to investigate the ideal nozzle position for maximizing drug delivery during PIPAC. Materials and Methods: We created 2 cm-, 4 cm- and 8 cm-ex vivo models according to the distance from the bottom to the nozzle using 21×15×16 cm-sized sealable plastic boxes. After each set of eight normal peritoneal tissues from swine were placed at eight different points (A to H), we performed PIPAC, compared the methylene blue staining areas to investigate the distribution, and estimated the depth of concentrated diffusion (DCD) and the depth of maximal diffusion (DMD) of doxorubicin. Results: In terms of distribution, the 4 cm- and 8 cm-ex vivo models showed more stained faces than the 2 cm-ex vivo model. Regarding the penetration depth, the 4 cm- ex vivo model showed the highest DCD (mean; 244.1 μm, C; 105.1 μm, D; 80.9 μm, E; 250.2 μm, G; 250.2 μm, H) and DMD (mean; 174.8 μm, D; 162.7 μm, E; 511.7 μm, F; 522.2 μm, G; 528.1 μm, H) in the most points corresponding to 62.5%. Conclusion: The ideal nozzle position during PIPAC might be halfway between the nozzle inlet and the bottom in the ex vivo model.

Key Words:
  • Nozzle
  • pressurized intraperitoneal aerosol chemotherapy
  • ex vivo model
  • peritoneal metastasis
  • intraperitoneal chemotherapy
  • Received August 3, 2021.
  • Revision received September 25, 2021.
  • Accepted September 28, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (11)
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Ideal Nozzle Position During Pressurized Intraperitoneal Aerosol Chemotherapy in an Ex Vivo Model
JINLAN PIAO, SOO JIN PARK, HEESU LEE, JUNSIK KIM, SUNWOO PARK, NARA LEE, SE IK KIM, MARIA LEE, GWONHWA SONG, JUNG CHAN LEE, HEE SEUNG KIM, ON BEHALF OF THE KORIA TRIAL GROUP
Anticancer Research Nov 2021, 41 (11) 5489-5498; DOI: 10.21873/anticanres.15362

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Ideal Nozzle Position During Pressurized Intraperitoneal Aerosol Chemotherapy in an Ex Vivo Model
JINLAN PIAO, SOO JIN PARK, HEESU LEE, JUNSIK KIM, SUNWOO PARK, NARA LEE, SE IK KIM, MARIA LEE, GWONHWA SONG, JUNG CHAN LEE, HEE SEUNG KIM, ON BEHALF OF THE KORIA TRIAL GROUP
Anticancer Research Nov 2021, 41 (11) 5489-5498; DOI: 10.21873/anticanres.15362
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Keywords

  • Nozzle
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  • ex vivo model
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