Table of Contents

Clinical Studies

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  Antibiotic Usage Reduced Overall Survival by over 70% in Non-small Cell Lung Cancer Patients on Anti-PD-1 Immunotherapy

  KAZUYUKI HAMADA, KIYOSHI YOSHIMURA, YUYA HIRASAWA, MASAHIRO HOSONUMA, MASAKAZU MURAYAMA, YOICHIRO NARIKAWA, HIROTSUGU ARIIZUMI, RYOTARO OHKUMA, MIDORI SHIDA, YUTARO KUBOTA, SATOSHI MATSUKUMA, TOMOYUKI ISHIGURO, TAKEHIKO SAMBE, ATSUSHI HORIIKE, ATSUO KURAMASU, SATOSHI WADA, JUNJI TSURUTANI, EISUKE INOUE, NAOKI UCHIDA, YUJI KIUCHI, SHINICHI KOBAYASHI, ROBERT M. HOFFMAN and TAKUYA TSUNODA

  Anticancer Research October 2021, 41 (10) 4985-4993; DOI: https://doi.org/10.21873/anticanres.15312
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  Updated Outcomes of Split Course Radiotherapy in Elderly or Infirm Patients With Advanced Cancers of the Head and Neck

  CHAIM DOMB, TIMOTHY D. SMILE, CHANDANA REDDY, NEIL M. WOODY, SHAUNA R. CAMPBELL, JOYCELIN F. CANAVAN, NIKHIL P. JOSHI, JOHN F GRESKOVICH, DEBORAH J. CHUTE, BRIAN B. BURKEY, LAMIE A. KU, ERIC LAMARRE, ROBERT R. LORENZ, BRANDON PRENDES, JOSEPH SCHARPF, LARISA SCHWARTZMAN, JESSICA L. GEIGER, SHLOMO A. KOYFMAN and CHRISTOPHER W. FLEMING

  Anticancer Research October 2021, 41 (10) 4995-5000; DOI: https://doi.org/10.21873/anticanres.15313
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  Symptom Outcomes of Cancer Patients With Clival Metastases Treated With Radiotherapy: A Study of 44 Patients

  REBECCA STURGIS, ALLEDA MACK, SEONGHO KIM, JORDAN MAIER and ELISABETH I. HEATH

  Anticancer Research October 2021, 41 (10) 5001-5006; DOI: https://doi.org/10.21873/anticanres.15314
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  An Exploratory Phase II Study of Eribulin Re-challenge After Short Term Therapy of 5-Fluorouracil for HER2 Negative, Advanced or Recurrent Breast Cancer

  TSUTOMU TAKASHIMA, SHIGEHIKO NISHIMURA, HIDEMI KAWAJIRI, YOKO MIZUYAMA, TAKEO NISHIMORI, SHIGEHITO YAMAGATA, SHINYA TOKUNAGA, KENJI TEZUKA, SEIKA TEI, TAKESHI SUNAMI, KATSUMI IKEDA, YOSHINARI OGAWA, SHINICHIRO KASHIWAGI, SATORU NODA, NAOYOSHI ONODA, TETSURO ISHIKAWA, SHINZOH KUDOH, MINORU TAKADA, KOSEI HIRAKAWA and MASAICHI OHIRA

  Anticancer Research October 2021, 41 (10) 5007-5014; DOI: https://doi.org/10.21873/anticanres.15315
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  Vascularized Bone Graft Reconstruction Following Bone Tumor Resection at a Multidisciplinary Sarcoma Center: Outcome Analysis

  SABINA M. GORSKI, CHAO DONG, ANDREAS. H. KRIEG and MARTIN HAUG

  Anticancer Research October 2021, 41 (10) 5015-5023; DOI: https://doi.org/10.21873/anticanres.15316
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  Role of the Cardiophrenic Lymph Node Status After Neoadjuvant Chemotherapy in Primary Advanced Ovarian Cancer

  VERONICA LUENGAS-WUERZINGER, FRIEDERIKE RAWERT, SABRINA CLAßEN-VON SPEE, SAHER BARANSI, ESTHER SCHULER, KATHARINA CARRIZO, PETER MALLMANN and BJOERN LAMPE

  Anticancer Research October 2021, 41 (10) 5025-5031; DOI: https://doi.org/10.21873/anticanres.15317
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  A Posterior-Anterior Cephalometric Study of Skull Symmetry in Patients With Neurofibromatosis Type 1

  REINHARD E. FRIEDRICH, GEORG CHRIST, HANNAH T. SCHEUER and HANNA A. SCHEUER

  Anticancer Research October 2021, 41 (10) 5033-5044; DOI: https://doi.org/10.21873/anticanres.15318
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  Sense of Coherence as Predictor of Quality of Life in Early Breast Cancer Patients

  NIINA VÄHÄAHO, LIISA HAKAMIES-BLOMQVIST, CARL BLOMQVIST, PIRKKO-LIISA KELLOKUMPU-LEHTINEN, RIIKKA HUOVINEN, TIINA SAARTO and CHRISTIAN HAKULINEN

  Anticancer Research October 2021, 41 (10) 5045-5052; DOI: https://doi.org/10.21873/anticanres.15319
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  Detectability of Lung Nodules in Ultra-low Dose CT

  SONJA JANSSEN, DANIEL OVERHOFF, MATTHIAS F. FROELICH, STEFAN O. SCHOENBERG and NILS RATHMANN

  Anticancer Research October 2021, 41 (10) 5053-5058; DOI: https://doi.org/10.21873/anticanres.15320
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  The Value of Post-treatment Surveillance for Detection of Loco-regional Recurrences in Oral Tongue Cancer

  FREDRIK LANDSTRÖM, ELIN ASPENBLAD, JOHAN REIZENSTEIN and STEFAN KRISTIANSSON

  Anticancer Research October 2021, 41 (10) 5059-5063; DOI: https://doi.org/10.21873/anticanres.15321
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  Risk Factors for Sleep Disturbances in Patients Scheduled for Radiotherapy of Head-and-Neck Cancer

  DIRK RADES, SVENJA KOPELKE, TAMER SOROR, TOBIAS BARTSCHT, SOEREN TVILSTED, TROELS W. KJAER and STEVEN E. SCHILD

  Anticancer Research October 2021, 41 (10) 5065-5069; DOI: https://doi.org/10.21873/anticanres.15322
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  The New Generation Immunochemical Test for Fecal Occult Blood (ColonView Quick Test) Shows a High Diagnostic Accuracy in Colorectal Cancer Detection

  JANNICA MEKLIN, MAARET ESKELINEN, DENISE PEIXOTO GUIMARAES, TUOMAS SELANDER, JENNI INKINEN, TAPANI TIUSANEN, KARI SYRJÄNEN and MATTI ESKELINEN

  Anticancer Research October 2021, 41 (10) 5071-5079; DOI: https://doi.org/10.21873/anticanres.15323
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  Consolidation of Tumorous Mandibular Ramus Defect During Denosumab Treatment for Rapidly Progressive Metastatic Breast Cancer

  REINHARD E. FRIEDRICH and ELIKA MADANI

  Anticancer Research October 2021, 41 (10) 5081-5087; DOI: https://doi.org/10.21873/anticanres.15324
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  Treatments and Outcomes in Oligometastatic Soft Tissue Soft Sarcoma – A Single Centre Retrospective Analysis

  GERARD M. WALLS, SHANE H. ZAIDI, NICOS FOTIADIS, SIMON JORDAN, MARCO MARUZZO, INTAN HAMID, OMAR AL-MUDERIS, KOMEL KHABRA, CHARLOTTE BENSON, ROBIN L. JONES, IAN R. JUDSON and AISHA B. MIAH

  Anticancer Research October 2021, 41 (10) 5089-5096; DOI: https://doi.org/10.21873/anticanres.15325
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  Can D3 Lymph Node Dissection for Patients With Colon Cancer With a Poor C-Reactive Protein/Albumin Ratio Improve Survival Outcomes?

  YOSUKE ATSUMI, MASAKATSU NUMATA, KEISUKE KAZAMA, SHINNOSUKE KAWAHARA, MIHWA JU, KENTA IGUCHI, SHO SAWAZAKI, TORU AOYAMA, AYAKO TAMAGAWA, SUMITO SATO, AKIO HIGUCHI, NOBUHIRO SUGANO, TENI GODAI, HIROSHI TAMAGAWA, HIROYUKI SAEKI, TAKASHI OSHIMA, MANABU SHIOZAWA, NORIO YUKAWA and YASUSHI RINO

  Anticancer Research October 2021, 41 (10) 5097-5106; DOI: https://doi.org/10.21873/anticanres.15326
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  Stereotactic and Hypofractionated Radiotherapy Associated With Immune Checkpoint Inhibitor Drugs: Analysis of Local Control, Toxicity, and Outcome in a Single Research Centre Case Study

  DIMITRI ANZELLINI, VITALIANA DE SANCTIS, MAURIZIO VALERIANI, CHIARA REVERBERI, LUCA MARINELLI, MARIA MASSARO, GIANLUCA VULLO, GIUSEPPE FACONDO, RICCARDO CARLO SIGILLO, EMANUELE TOSI and MATTIA FALCHETTO OSTI

  Anticancer Research October 2021, 41 (10) 5107-5116; DOI: https://doi.org/10.21873/anticanres.15327
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  The Role of Serum Tumor Markers in Follow-up After Surgical Treatment of Malignant Lung Tumors

  JOSEF VODICKA, MARTIN SKALA, JAKUB SEBEK, VLADISLAV TRESKA, JAKUB FICHTL, KRISTYNA PROCHAZKOVA, BOHUSLAVA VANKOVA, MARTIN SVATON, LADISLAV PECEN, ONDREJ TOPOLCAN, MONIKA BLUDOVSKA and RADEK KUCERA

  Anticancer Research October 2021, 41 (10) 5117-5122; DOI: https://doi.org/10.21873/anticanres.15328
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  Postoperative Outcomes of Tangential versus Segmental Resection and End-to-end Reconstruction of the Superior Mesenterico-Portal Vein During Pancreatoduodenectomy for Pancreatic Adenocarcinoma: A Single-Center Experience

  HRYHORIY LAPSHYN, THERESA SCHULTE, NATALIE PETRUCH, EKATERINA PETROVA, KIM HONSELMANN, STEFFEN DEICHMANN, RÜDIGER BRAUN, BIRTE KULEMANN, JENS HOEPPNER, DIRK RADES, TOBIAS KECK, ULRICH F. WELLNER, DIRK BAUSCH and LOUISA BOLM

  Anticancer Research October 2021, 41 (10) 5123-5130; DOI: https://doi.org/10.21873/anticanres.15329
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  Intensity-modulated Radiotherapy in Patients With Aggressive Extranodal Non-Hodgkin Lymphoma of the Head and Neck

  JENS EISMANN, KHALED ELSAYAD, DANIEL ROLF, IQBAL SARIF, EVA WARDELMANN, HENDRIK BERSSENBRÜGGE, GEORG LENZ and HANS THEODOR EICH

  Anticancer Research October 2021, 41 (10) 5131-5135; DOI: https://doi.org/10.21873/anticanres.15330
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  Comparison Between Second- and Third-generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors as First-line Treatment in Patients With Non-small-cell Lung Cancer: A Retrospective Analysis

  SHO MITSUYA, KENJIRO TSURUOKA, KIYOE KANAOKA, TOMOYA FUNAMOTO, HIROYUKI TSUJI, NINSO MATSUNAGA, TAKAHIKO NAKAMURA, YOSUKE TAMURA, MASAFUMI IMANISHI, SOICHIRO IKEDA, YASUHITO FUJISAKA, ISAO GOTO and AKIHISA IMAGAWA

  Anticancer Research October 2021, 41 (10) 5137-5145; DOI: https://doi.org/10.21873/anticanres.15331
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  Second-line Chemotherapy for Previously Treated Metastatic Small Bowel Adenocarcinoma: A Retrospective Analysis

  TAIKO NAKAZAWA, YUKIYA NARITA, RYOSUKE KUMANISHI, TAKATSUGU OGATA, YUKI MATSUBARA, KAZUKI NOZAWA, KYOKO KATO, KAZUNORI HONDA, TOSHIKI MASUISHI, HIDEAKI BANDO, SHIGENORI KADOWAKI, MASASHI ANDO, KAZUO HARA, MASAHIRO TAJIKA and KEI MURO

  Anticancer Research October 2021, 41 (10) 5147-5155; DOI: https://doi.org/10.21873/anticanres.15332
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  Immunonutritional Indices in Non-small-cell Lung Cancer Patients Receiving Adjuvant Platinum-based Chemotherapy

  TAICHI MATSUBARA, FUMIHIKO HIRAI, MASAFUMI YAMAGUCHI and MOTOHARU HAMATAKE

  Anticancer Research October 2021, 41 (10) 5157-5163; DOI: https://doi.org/10.21873/anticanres.15333
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  Frequency and Risk Factors of Sleep Disturbances in Patients With Prostate Cancer Assigned to Local or Loco-regional Radiotherapy

  SVENJA KOPELKE, TOBIAS BARTSCHT, STEVEN E. SCHILD, SOEREN TVILSTED, TROELS W. KJAER and DIRK RADES

  Anticancer Research October 2021, 41 (10) 5165-5169; DOI: https://doi.org/10.21873/anticanres.15334
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  Clinical Predictors of Unresectable Disease at Laparotomy in Patients With Pancreatic Ductal Adenocarcinoma Planning to Undergo Surgical Resection

  TAKAYUKI SHIMIZU, TAKU AOKI, SHUN SATO, TAKATSUGU MATSUMOTO, TAKAYUKI SHIRAKI, YUHKI SAKURAOKA, SHOZO MORI, YUKIHIRO ISO, MITSURU ISHIZUKA and KEIICHI KUBOTA

  Anticancer Research October 2021, 41 (10) 5171-5177; DOI: https://doi.org/10.21873/anticanres.15335
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  Clinical Significance of ¹⁸F-fluorodeoxyglucose and Glucose Transporter 1 mRNA in Clear Cell Renal Cell Carcinoma

  HIRONORI BETSUNOH, SETSU SAKAMOTO, YASUSHI KAJI, AKINORI NUKUI, MINORU KOBAYASHI, MASAHIRO YASHI, KEITARO HAYASHI, NAOHIKO ANZAI and TAKAO KAMAI

  Anticancer Research October 2021, 41 (10) 5179-5188; DOI: https://doi.org/10.21873/anticanres.15336
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  Impact of Inferior Mesenteric Artery Occlusion on the Calibre of Collateral Arteries of the Colon

  TETSUHIRO IIDA, KOJI MURONO, HIROSHI SHIRATORI, HIROAKI NOZAWA, KAZUSHIGE KAWAI, KAZUHITO SASAKI, SHIGENOBU EMOTO, JUNKO KISHIKAWA, HIROAKI ISHII, YUICHIRO YOKOYAMA, SHINYA ABE, YUZO NAGAI, HIROYUKI ANZAI, HIROFUMI SONODA, TOSHIO TAKAYAMA, KATSUYUKI HOSHINA and SOICHIRO ISHIHARA

  Anticancer Research October 2021, 41 (10) 5189-5193; DOI: https://doi.org/10.21873/anticanres.15337
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  Preoperative Pre-albumin Concentration as a Predictor of Short-term Outcomes in Elderly Patients With Colorectal Cancer

  SUMITO SATO, MANABU SHIOZAWA, SUGURU NUKADA, KENTA IGUCHI, KEISUKE KAZAMA, YOSUKE ATSUMI, MASAKATSU NUMATA, HIROSHI TAMAGAWA, KUNIYA TANAKA, TAKASHI OSHIMA and YASUSHI RINO

  Anticancer Research October 2021, 41 (10) 5195-5202; DOI: https://doi.org/10.21873/anticanres.15338
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  Morphomics Can Predict Oncological Features and Survival of Metastatic Renal Cell Carcinoma After Cytoreductive Nephrectomy

  I-HUNG SHAO, YING-HSU CHANG, TING-WEN SHENG, CHIN-CHIEH TAN, LI-JEN WANG, CHENG-KENG CHUANG, CHUN-TE WU and SEE-TONG PANG

  Anticancer Research October 2021, 41 (10) 5203-5211; DOI: https://doi.org/10.21873/anticanres.15339
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  Impact of Frailty on Treatment Outcome in Patients With Locally Advanced Esophageal Cancer Undergoing Concurrent Chemoradiotherapy

  YUNG-HSIN HUANG, YU-SHIN HUNG, CHENG-CHOU LAI, MING-MO HO, KUN-YUN YEH, CHIEH YANG, CHANG-HSIEN LU, CHEN-KAN TSENG, NGAN-MING TSANG, CHIA-YEN HUNG, SHUN-WEN HSUEH, PEI-HUNG CHANG, YA-WEN HO, YU-CHING LIN and WEN-CHI CHOU

  Anticancer Research October 2021, 41 (10) 5213-5222; DOI: https://doi.org/10.21873/anticanres.15340
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  Pancreaticoduodenectomy at a Non-high-volume Center and Efforts to Perform Safe Surgery

  TAISHI YAMANE, DAISUKE IZUMI, SHOTARO KINOSHITA, CHIKA SHIRAKAMI, KEISUKE MORITA, SATOSHI IKESHIMA, KEI HORINO, SHINYA SHIMADA and HIDEO BABA

  Anticancer Research October 2021, 41 (10) 5223-5229; DOI: https://doi.org/10.21873/anticanres.15341
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  Efficacy and Feasibility of Adjuvant Gemcitabine Plus Cisplatin Chemotherapy After Major Hepatectomy for Biliary Tract Cancer

  SHOZO MORI, TAKU AOKI, TAKAYUKI SHIRAKI, TAKAYUKI SHIMIZU, TAKAMUNE YAMAGUCHI, KYUNG-HWA PARK, TAKATSUGU MATSUMOTO, YUHKI SAKURAOKA, YUKIHIRO ISO and KEIICHI KUBOTA

  Anticancer Research October 2021, 41 (10) 5231-5240; DOI: https://doi.org/10.21873/anticanres.15342
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  Chemoembolization for Hepatocellular Carcinoma in Patients With Inferior Vena Caval/Right Atrial Tumor Thrombi Without Hepatic Vein Invasion

  MINUK KIM, HYO-CHEOL KIM and JIN WOOK CHUNG

  Anticancer Research October 2021, 41 (10) 5241-5247; DOI: https://doi.org/10.21873/anticanres.15343
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  Intrahepatic Cholangiocarcinoma Coexisting With Multiple Bile Duct Adenoma Treated as Liver Metastasis from a Pancreatic Neuroendocrine Tumor

  ERI ODA, KENSUKE YAMAMURA, YOSHIHIRO HARA, KAZUKI MATSUMURA, SHINICHI AKAHOSHI, HIDEAKI YUKI, TOSHIHIKO MOTOHARA, HIDEAKI MIYAMOTO, KOICHI KINOSHITA, FUJIO MATSUMURA, KOJI OHNISHI, YOSHIHIRO KOMOHARA and TORU BEPPU

  Anticancer Research October 2021, 41 (10) 5249-5254; DOI: https://doi.org/10.21873/anticanres.15344