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Research ArticleExperimental Studies

Activation-Induced Cytidine Deaminase Promotes Proliferation and Enhances Chemoresistance and Migration in B-cell Lymphoma

GRANT GODSMARK, LEONARDO ALVES DE SOUZA RIOS and SHAHEEN MOWLA
Anticancer Research January 2021, 41 (1) 237-247; DOI: https://doi.org/10.21873/anticanres.14770
GRANT GODSMARK
Division of Haematology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
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LEONARDO ALVES DE SOUZA RIOS
Division of Haematology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
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SHAHEEN MOWLA
Division of Haematology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
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  • For correspondence: shaheen.mowla@uct.ac.za
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Abstract

Background/Aim: Activation-induced cytidine deaminase (AID) is a DNA modifying enzyme which has an essential function in promoting antibody diversification. Its overexpression is strongly associated with B-cell derived malignancies including Burkitt lymphoma, where AID is required for the characteristic c-MYC/IGH translocation. This study aimed at defining AID’s oncopathogenic role which is still poorly understood. Materials and Methods: We created over-expressing and knock-down cell culture models of AID, and used cellular assays to provide insight into its contribution to lymphomagenesis. Results: We showed that AID expression is highly specific to, and abundantly expressed in B-cell-derived cancers and that ectopic overexpression of AID leads to rapid cell death. Using a knock-down model, we revealed that AID expression significantly impacts genomic stability, proliferation, migration and drug resistance. Conclusion: AID is an important driver of lymphoma, impacting multiple cellular events, and is potentially a strong candidate for targeted therapy in lymphoma.

Key Words:
  • Activation-induced cytidine deaminase
  • Burkitt lymphoma
  • DNA damage
  • proliferation
  • migration
  • Received November 24, 2020.
  • Revision received December 15, 2020.
  • Accepted December 16, 2020.
  • Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (1)
Anticancer Research
Vol. 41, Issue 1
January 2021
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Activation-Induced Cytidine Deaminase Promotes Proliferation and Enhances Chemoresistance and Migration in B-cell Lymphoma
GRANT GODSMARK, LEONARDO ALVES DE SOUZA RIOS, SHAHEEN MOWLA
Anticancer Research Jan 2021, 41 (1) 237-247; DOI: 10.21873/anticanres.14770

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Activation-Induced Cytidine Deaminase Promotes Proliferation and Enhances Chemoresistance and Migration in B-cell Lymphoma
GRANT GODSMARK, LEONARDO ALVES DE SOUZA RIOS, SHAHEEN MOWLA
Anticancer Research Jan 2021, 41 (1) 237-247; DOI: 10.21873/anticanres.14770
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Keywords

  • Activation-induced cytidine deaminase
  • Burkitt lymphoma
  • DNA damage
  • proliferation
  • migration
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