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Review ArticleReviews

Inguinal GIST: A Systematic Literature Review of Primary and Metastatic Cases

EDOARDO VIRGILIO, ALFREDO ANNICCHIARICO, LORENZO PAGLIAI, ANDREA MORINI, ANDREA ROMBOLI, FILIPPO MONTALI and RENATO COSTI
Anticancer Research January 2021, 41 (1) 21-25; DOI: https://doi.org/10.21873/anticanres.14748
EDOARDO VIRGILIO
1Department of Medicine and Surgery, University of Parma, Parma, Italy;
2Department of General Surgery, di Vaio Hospital, Fidenza, Italy;
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  • For correspondence: edoardo.virgilio@unipr.it
ALFREDO ANNICCHIARICO
1Department of Medicine and Surgery, University of Parma, Parma, Italy;
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LORENZO PAGLIAI
1Department of Medicine and Surgery, University of Parma, Parma, Italy;
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ANDREA MORINI
1Department of Medicine and Surgery, University of Parma, Parma, Italy;
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ANDREA ROMBOLI
1Department of Medicine and Surgery, University of Parma, Parma, Italy;
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FILIPPO MONTALI
2Department of General Surgery, di Vaio Hospital, Fidenza, Italy;
3Department of Experimental Medicine, University of L’Aquila, L’Aquila, Italy
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RENATO COSTI
1Department of Medicine and Surgery, University of Parma, Parma, Italy;
2Department of General Surgery, di Vaio Hospital, Fidenza, Italy;
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Abstract

Background/Aim: Gastrointestinal stromal tumor (GIST) has a wide spectrum of clinical manifestations. Involvement of the groin region can cause interesting presentations but, as of 2020, has rarely been investigated. Our aim was to assess the clinicopathological and prognostic features of GIST appearing in this specific part of the body. Materials and Methods: We investigated the world literature dealing with primary or metastatic GIST appearing in the inguinal region (IGIST). A case of metastatic IGIST from our clinical records was also included. Results: We found only six cases of primary and nine of metastatic IGIST. All were of male gender, and most aged 60 years or more (10 cases). Inguinal hernia (11 cases) was the patient type most frequently affected. The association between metastatic IGIST and inguinal lymphadenopathy was statistically significant (p=0.049). Conclusion: IGIST is a rare entity with particular clinical manifestations. Inguinal hernia and inguinal lymphadenopathy should be carefully investigated in patients with a history of GIST.

Key Words:
  • Gastrointestinal stromal tumor
  • GIST
  • inguinal hernia
  • inguinal hernia sac
  • review

Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasm in the gastrointestinal (GI) tract (80%) (1). Their estimated incidence is approximately 1/100,000 per year; male patients in their 60s represent the population most commonly affected (2). GISTs originate from stem cells differentiating toward interstitial cells of Cajal and expressing, in the vast majority of cases, specific receptors (tyrosine kinase receptor KIT or platelet-derived growth factor receptor alpha) and markers such as CD117 antigen (an epitope of the KIT receptor). However, dedifferentiation to a de novo or anaplastic KIT-negative phenotype post-imatinib mesylate treatment is possible (3, 4). GISTs usually arise from the GI tract (in descending order: stomach in 60-70%, small bowel in 20-30%, colorectum in 5%, esophagus in under 5%) but occasionally an extra-intestinal origin is observed (EGIST: omentum-mesentery-peritoneum in 5% and retroperitoneum in under 3%) (2, 5). Differential diagnosis from other mesenchymal tumors or subepithelial reactive processes can be challenging for pathologists and includes, inter alia, intra-abdominal fibromatosis, dedifferentiated liposarcoma, reactive nodular fibrous pseudotumor of the GI tract or mesentery and colonic ischemic pseudotumor (6-8). GISTs can run an asymptomatic course but can also manifest with pain, masses or bleeding involving the abdomen and GI system (9-11). The groin region represents a particular localization for GIST. At this level, in fact, the clinical scenario can be extremely variable, presenting as an inguinal bulge or lump, from soft to firm, reducible or non-tender, painless or complicated by local or systemic signs of inflammation (12-25). All of these manifestations can be the result of a primary or metastatic GIST located in the GI tract, lymph nodes (LNs) or soft tissues. Since, with the exception of a few anecdotal experiences and case reports, literature has rarely investigated inguinal GIST (IGIST), our aim was to offer a systematic review of this specific presentation assessing the main clinicopathological and prognostic features of IGIST.

Materials and Methods

We systematically reviewed world literature on IGIST. Investigation was carried out through eight popular search engines (PubMed, Science Direct, Scopus, Web of Science, Google Scholar, ResearchGate, Publons and Academia). Gastrointestinal stromal tumor, GIST, EGIST, inguinal GIST, inguinal hernia GIST, groin GIST, GIST sac, primary GIST and metastatic IGIST were the key words utilized for searching. English and non-English articles were considered. All other kinds of malignancies involving the inguinal canal were excluded from the review. We also included one case of metastatic IGIST present in our clinical records. The patient, an 89-year-old man who underwent resection of a stomach GIST 6 years earlier, experienced acute abdominal pain of 4 days’ duration. On examination, a painful, irreducible and non-pulsatile mass was palpated in his left groin and an incarcerated inguinal hernia was suspected. At surgery, after opening the hernia sac, multiple bleeding congested nodules were observed encumbering an intestinal loop. Intraoperative histology revealed metastatic IGIST. Hemostasis was achieved using electrocautery and the inguinal defect repaired with Lichtenstein tension-free mesh technique. Three days after surgery, the patient died of acute kidney failure and cardiac arrest.

Statistics. Statistical analysis of the reviewed data was performed using MedCalc® Statistical Software version 19.6 (Ostend, Belgium; https://www.medcalc.org; 2020). Categorical and continuous variables were compared with the chi-square test and the Student’s t-test, respectively. Univariate analysis was conducted through one-way and two-way analysis of variance. Multivariate analysis was assessed with Cox proportional hazards model. A value of p≤0.05 was considered statistically significant.

Results

As of 2020, after examining the relevant literature, we found only 14 articles describing 14 patients with an inguinal manifestation of GIST: interestingly, all were case reports (12-25). Six tumors were primary GIST (12-17) (Table I) while the others were metastatic IGISTs (18-25) (Table II). To the latter list, we also added the case of metastatic IGIST taken from our clinical records. The vast majority of cases involved male sex (M/F: 14/1), age 60 years and over (11 patients, 78.6%), irreducible inguinal hernia (10 cases) and a GIST with GI origin (eight cases). Seven out of the 10 interventions for inguinal hernia repair were accomplished with or followed by surgical excision of the main mass. Interestingly, the finding of an inguinal lymph node (iLN) as a manifestation of metastatic IGIST was statistically significant (p=0.049) at univariate analysis. Correlation of metastatic IGIST with iLN plus duration of clinical scenario ≥10 days was borderline significant (p=0.08). All the other results from univariate and multivariate analyses of the reviewed primary and metastatic IGISTs did not achieve statistical significance. Regarding survival, there were two deaths in the group with metastatic IGIST, one due to tumor progression, the other following postoperative renal and cardiac complications (Table II).

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Table I.

Literature review of primary cases of gastrointestinal stromal tumors manifesting in the groin region.

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Table II.

Review of cases of metastatic gastrointestinal stromal tumor (mIGIST) manifesting in the groin region.

Discussion

In keeping with the pertinent literature, the reviewed patient population were mainly composed of men in their 60s having a concomitant or previous primary GIST arising from the GI tract (2, 4). Currently, several clinicopathologicaI features of GIST have been well documented and associated with high risk of malignant potential, recurrence and poor prognosis, such as high proliferative index, tumor dimension larger than 5-10 cm, extra-gastric localization, rupture, GI hemorrhage, lack or mutation of a specific receptor helpful for targeted therapy, development of a de novo or post-imatinib anaplastic dedifferentiation and presence of lymph node or distant metastases (4, 26-30). A clinical manifestation starting in the groin may represent a further risk factor of dismal prognosis in GIST. Our review of world literature showed that IGIST has rarely been studied and most knowledge comes from single case reports; despite this, we found several clinical associations and prognostic similarities between IGIST and GIST presenting the aforementioned traditional predictors of poor survival (12-25). Age ≥60 years appears a very common characteristic in the IGIST population (11 out of 14 patients considering both primary and metastatic cases). Although no statistical association between age and IGIST was found by our analysis, some authors formerly demonstrated that overall and disease-specific-survival of patients with GIST older than 50 years were significantly lower than young patients and this was confirmed at least for the group with metastatic IGIST (for patients >60 years, two deaths, one with tumor progression) (19, 31). Female gender seems a protective feature in GIST and this may also be true for IGIST (in fact, 93% of patients with IGIST were men) (31). A silent or irreducible hernia was the most frequent clinical manifestation affecting the groin region (11/14 cases). Regarding primary cases, the protruding tumors arose from the small bowel in three, large bowel in one and retroperitoneum in two cases (Table I); concerning metastatic IGISTs, deposits in the inguinal canal were derived from the small bowel in two, large bowel in one and retroperitoneum in two cases (Table II). Characteristically, all these sites are associated with a malignant potential higher than that of gastric origin (28-31). Interestingly, metastatic IGIST significantly correlated with the presence of inguinal lymphadenopathy (p=0.049): therefore, the appearance of an iLN in a patient with previous or concomitant history of GIST should always be suspected as a metastasis from primary tumor and investigated before surgical excision. GI bleeding comprises a traditional feature of malignancy for GIST: in the group with metastatic IGIST, three patients presented with hemorrhagic complications of the groin (22, 25). Metastatic IGIST also presented in the inguinal regional in the shape of a nodule (two cases) or mass (two cases).

Etiopathogenesis of IGIST presenting with inguinal hernia is rather interesting and varies depending on the phase of disease. An intrabdominal (intestinal, colonic, peritoneal or retroperitoneal) primary GIST can drop into the inguinal canal, causing a silent or incarcerated inguinal hernia (12-14, 16, 17). Inguinal hernia can also be the clinical manifestation of a metastatic IGIST; since the lymphatic route is improbable for GIST, some authors have hypothesized that neoplastic cells might be released from the primary tumor spontaneously (due to enlargement of the tumor mass with subsequent hypovascularization, hypoxia, necrosis and crevice of the most peripheral areas), or following surgical maneuvers executed during a former intervention for GIST, then be exfoliated into the peritoneal cavity and become trapped by the narrow neck of a pre-existing inguinal hernial sac (21). Concerning inguinal hernia, some authors have also suggested that a longstanding silent hernia which becomes acutely incarcerated has a higher risk of containing a cancer: One patient with primary and another with metastatic IGIST having a silent longstanding inguinal hernia became symptomatic after 6 and 4 months, respectively (13, 20, 32, 33).

Conclusion

IGIST comprises a particular clinical presentation for GIST/EGIST and its prognostic features should be further addressed by future studies. The groin region can be affected by IGIST in several ways. A clinical suspicion of inguinal metastasis should always be considered when managing patients with a previous medical history of GIST. In this category of patients with inguinal hernia or iLN, preoperative investigation and exploration of the hernia sac should always be mandatory.

Footnotes

  • Authors’ Contributions

    All the authors agreed with the content of the article. Dr. Virgilio conceived the research idea. Dr. Virgilio wrote the article. Dr. Annicchiarico and Dr. Pagliai reviewed the literature. Dr. Montali selected patients amenable to inclusion or exclusion. Dr. Morini prepared the tables. Dr. Costi supervised the entire project.

  • This article is freely accessible online.

  • Conflicts of Interest

    The Authors declare no conflicts of interest.

  • Received November 26, 2020.
  • Revision received December 6, 2020.
  • Accepted December 8, 2020.
  • Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

References

  1. ↵
    1. Takahashi R,
    2. Toyokawa T,
    3. Yoshi M,
    4. Tamura T,
    5. Tanaka H,
    6. Lee S,
    7. Muguruma K,
    8. Yashiro M and
    9. Ohira M
    : A giant gastric gastrointestinal stromal tumor successfully resected following neoadjuvant treatment with imatinib mesylate. Anticancer Res 40: 1147-1152, 2020. PMID: 32014967. DOI: 10.21873/nticanres.14056
    OpenUrlAbstract/FREE Full Text
  2. ↵
    1. Boukovinas I,
    2. Kotsakis A,
    3. Androulakis N,
    4. Aravantinos G,
    5. Michalaki V,
    6. Christodoulou C,
    7. Avgerinos A,
    8. Papandreou C,
    9. Sidiropoulou V,
    10. Kousidou O and
    11. Kosmidis P
    : Recurrence-free survival and safety of imatinib in patients with gastrointestinal stromal tumour (GIST) in Greece. Anticancer Res 40: 435-441, 2020. PMID: 31892598. DOI: 10.21873/anticanres.13971
    OpenUrlAbstract/FREE Full Text
  3. ↵
    1. Fröbom R,
    2. Sellberg F,
    3. Xu C,
    4. Zhao A,
    5. Larsson C,
    6. Lui WO,
    7. Nilsson IL,
    8. Berglund E and
    9. Bränström R
    : Biochemical inhibition of DOG1/TMEM16A achieves antitumoral effects in human gastrointestinal stromal tumor cells in vitro. Anticancer Res 39: 3433-3442, 2019. PMID: 31262867. DOI: 10.21873/anticanres.13489
    OpenUrlAbstract/FREE Full Text
  4. ↵
    1. Virgilio E,
    2. Mercantini P,
    3. Tarantino G,
    4. Socciarelli F,
    5. Pilozzi E,
    6. Uccini S,
    7. Caterino S and
    8. Ziparo V
    : Gastrointestinal stromal tumors with de novo anaplastic dedifferentiation: considerations on a little-known neoplastic metamorphosis. Int J Surg Pathol 22: 385, 2014. PMID: 24487042. DOI: 10.1177/1066896914521288
    OpenUrlCrossRefPubMed
  5. ↵
    1. Mochizuki K,
    2. Kondo T,
    3. Oishi N,
    4. Tahara I,
    5. Inoue T,
    6. Kasai K,
    7. Nakazawa T and
    8. Katoh R
    : Single-stranded DNA (ssDNA) labeling index is related to risk grade in patients with gastrointestinal stromal tumors. Anticancer Res 38: 2939-2943, 2018. PMID: 29715120. DOI: 10.21873/anticanres.12542
    OpenUrlAbstract/FREE Full Text
  6. ↵
    1. Virgilio E,
    2. Pucci E,
    3. Pilozzi E,
    4. Mongelli S,
    5. Cavallini M and
    6. Ferri M
    : Reactive nodular fibrous pseudotumor of the gastrointestinal tract and mesentery giving multiple hepatic deposits and associated with colon cancer. Am Surg 78: 262-264, 2012. PMID: 22546099.
    OpenUrl
    1. Aurello P,
    2. Virgilio E,
    3. Sirimarco D,
    4. Novi L,
    5. D’Angelo F and
    6. Ramacciato G
    : Dedifferentiated liposarcoma of the retropertoneum with osteosarcomatous component. Int J Surg Pathol 21: 314-315, 2013. PMID: 23426961. DOI: 10.1177/1066896913476749
    OpenUrlCrossRefPubMed
  7. ↵
    1. Virgilio E,
    2. Mercantini P,
    3. Ferri M,
    4. Corleto VD,
    5. Sparagna A and
    6. Ziparo V
    : Ischemic pseudotumor of the colon: an insidious form of ischemic colitis. World J Surg 36: 2949-2950, 2012. PMID: 22864568. DOI: 10.1007/s00268-012-1739-1
    OpenUrlCrossRefPubMed
  8. ↵
    1. Costi R,
    2. Le Bian A,
    3. Creuze N,
    4. Prevot S,
    5. Cauchy F,
    6. Violi V and
    7. Smadja C
    : Hemoperitoneum caused by a ruptured GIST located in the posterior gastric wall managed by endoscopic diagnosis and laparoscopic treatment: Case report and literature review. Surg Laparosc Endosc Percutan Tech 21: 316-318, 2011. PMID: 22146181. DOI: 10.1097/SLE.0b013e318231998b
    OpenUrlCrossRef
    1. Sekido Y,
    2. Ohigashi S,
    3. Takahashi T,
    4. Hayashi N,
    5. Suzuki K and
    6. Hirota S
    : Familial gastrointestinal stromal tumor with germline KIT mutations accompanying hereditary breast and ovarian cancer syndrome. Anticancer Res 37: 1425-1432, 2017. PMID: 28314314. DOI: 10.21873/anticanres.11466
    OpenUrlAbstract/FREE Full Text
  9. ↵
    1. Abu-Amna M,
    2. Awadie H and
    3. Bar-Sela G
    : Imatinib-induced gastrointestinal vascular ectasia in a patient with advanced GIST: Case report and literature review. Anticancer Res 36: 6151-6154, 2016. PMID: 27793944. DOI: 10.21873/anticanres.11206
    OpenUrlAbstract/FREE Full Text
  10. ↵
    1. Chan SY,
    2. Law WL and
    3. Chu KW
    : Gastrointestinal stromal tumour presenting as incarcerated inguinal hernia. ANZ J Surg 74: 391-392, 2004. PMID: 15144272. DOI: 10.1111/j.1445-1433.2004.03004.x
    OpenUrlCrossRefPubMed
  11. ↵
    1. Mulla M,
    2. Yeung J and
    3. Reynolds J
    : Gastrointestinal stromal tumour (GIST) mimicking an indirect inguinal hernia, a rare presentation. Eur Surg 39: 270-272, 2007. DOI: 10.1007/s10353-007-0342-4
    OpenUrlCrossRef
  12. ↵
    1. Tinoco-Gonzàlez J
    : Gastrointestinal stromal tumor (GIST) presenting as a groin mass mimicking an incarcerated hernia. Int J Surg Case Rep 6C: 166-168, 2015. PMID: 25544483. DOI: 10.1016/j.ijscr.2014.09.001
    OpenUrlCrossRef
    1. Agrawala SK,
    2. Panda PC,
    3. Samal D,
    4. Hansa J,
    5. Mohanty DP,
    6. Sahoo MK and
    7. Kannan R
    : Gastrointestinal stromal tumour (GIST) presenting as inguinal mass – an unusual presentation and literature review. Int J Pharm Sci Rev Res 44: 112-114, 2017.
    OpenUrl
  13. ↵
    1. Massani M,
    2. Capovilla G,
    3. Ruffolo C and
    4. Bassi N
    : Gastrointestinal stromal tumour (GIST) presenting as a strangulated inguinal hernia with small bowel obstruction. BMJ Case Rep 2017: bcr2016217273, 2017. PMID: 28104721. DOI: 10.1136/bcr-2016-217273
    OpenUrlAbstract/FREE Full Text
  14. ↵
    1. Zhou Y,
    2. Wu X-D,
    3. Shi Q,
    4. Zhou B and
    5. Jia J
    : A retroperitoneal gastrointestinal stromal tumor (GIST) with inguinal lymph node metastasis: a case report. Int J Clin Exp Med 10: 13935-13937, 2017.
    OpenUrl
  15. ↵
    1. Zhang Q,
    2. Yu JW,
    3. Yang WL,
    4. Liu XS and
    5. Yu JR
    : Gastrointestinal stromal tumor of stomach with inguinal lymph nodes metastasis: A case report. World J Gastroenterol 16: 1808-1810, 2010. DOI: 10.3748/wjg.v16.i14.1808
    OpenUrlCrossRefPubMed
  16. ↵
    1. Vassos N,
    2. Agaimy A,
    3. Hohenberger W and
    4. Croner RS
    : Extraabdominal lymph node metastasis in gastrointestinal stromal tumors (GIST). J Gastrointest Surg 15: 1232-1236, 2011. DOI: 10.1007/s11605-011-1464-3
    OpenUrlCrossRefPubMed
  17. ↵
    1. Raval P,
    2. Unadkat S and
    3. Kirthi V
    : Rare and unusual metastases of a gastrointestinal stromal tumour. J Park Med Assoc 63: 148-149, 2013. PMID: 23865157.
    OpenUrl
  18. ↵
    1. Goyal A,
    2. Mansel RE and
    3. Goyal S
    : Gastrointestinal stromal tumour in an inguinal hernia sac: An unusual presentation. Postgrad Med J 79: 707-708, 2003. PMID: 14707251.
    OpenUrlPubMed
  19. ↵
    1. Kitamura D,
    2. Ikeda K,
    3. Unotoro J,
    4. Seki E,
    5. Gonda H and
    6. Izumi H
    : A case of multiple metastatic giant rectal GIST successfully treated with surgical intervention after administration of imatinib mesylate. Nihon Shokakibyo Gakkai Zasshi 110: 74-80, 2013. PMID: 23303232.
    OpenUrl
    1. Liu PH,
    2. Kung WC,
    3. Wu YC,
    4. Chien ST,
    5. Chang WY and
    6. Hsu CW
    : Metastatic malignant gastrointestinal stromal tumor mimicking a right incarcerated inguinal hernia. Formosan J Surg 47: 189-192, 2014. DOI: 10.1016/j.fjs.2014.04.003
    OpenUrlCrossRef
    1. Campbell R,
    2. Hashmi A,
    3. Hunsinger M,
    4. Shabahang M,
    5. Blansfield J and
    6. Alaparthi M
    : Incidental finding of a gastrointestinal stromal tumor during an inguinal hernia repair. JSM Gen Surg Cases Images 2: 1024, 2017.
    OpenUrl
  20. ↵
    1. Ferhatoglu MF,
    2. Kartal A and
    3. Kivilcim T
    : Gastrointestinal stromal tumor mimicking such as incarcerated inguinal hernia. Med Sci Disc 5: 166-168, 2018. DOI: 10.17546/msd.407478
    OpenUrlCrossRef
  21. ↵
    1. Fletcher CD,
    2. Berman JJ,
    3. Corless C,
    4. Gorstein F,
    5. Lasota J,
    6. Longley BJ,
    7. Miettinen M,
    8. O’Leary TJ,
    9. Remotti H,
    10. Rubin BP,
    11. Shmookler B,
    12. Sobin LH and
    13. Weiss SW
    : Diagnosis of gastrointestinal stromal tumors: A consensus approach. Int J Surg Pathol 10: 81-89, 2002. PMID: 12075401. DOI: 10.1177/106689690201000201
    OpenUrlCrossRefPubMed
    1. Hompland I and
    2. Bruland ØS
    : Can imatinib be safely withdrawn in patients with surgically resected metastatic GIST? Anticancer Res 35: 5759-5765, 2015. PMID: 26503996.
    OpenUrlAbstract/FREE Full Text
  22. ↵
    1. Miyamoto H,
    2. Kunisaki C,
    3. Otsuka Y,
    4. Takahashi M,
    5. Takagawa R,
    6. Misuta K,
    7. Kameda K,
    8. Makino H,
    9. Matsuda G,
    10. Yamaguchi N,
    11. Kamiya N,
    12. Murakami T,
    13. Morita S,
    14. Akiyama H and
    15. Endo I
    : Macroscopic type is a prognostic factor for recurrence-free survival after resection of gastric GIST. Anticancer Res 34: 4267-4273, 2014. PMID: 25075057.
    OpenUrlAbstract/FREE Full Text
    1. Vallböhmer D,
    2. Marcus HE,
    3. Baldus SE,
    4. Brabender J,
    5. Lurje G,
    6. Drebber U,
    7. Metzger R,
    8. Hölscher AH and
    9. Schneider PM
    : Comparative analysis of four histopathological classification systems to discriminate benign and malignant behaviour in gastrointestinal stromal tumors. Anticancer Res 28: 367-372, 2008. PMID: 18383871.
    OpenUrlAbstract/FREE Full Text
  23. ↵
    1. Kovac D,
    2. Petrovecki M,
    3. Jasic M,
    4. Dobi-Babic R,
    5. Ivanis N,
    6. Rubinic M,
    7. Krizanac S,
    8. Jonjic N,
    9. Rizzardi C and
    10. Melato M
    : Prognostic factors of gastrointestinal stromal tumors. Anticancer Res 22: 1913-1917, 2002. PMID: 12168893.
    OpenUrlPubMed
  24. ↵
    1. Kramer K,
    2. Knippschild U,
    3. Mayer B,
    4. Bögelspacher K,
    5. Spatz H,
    6. Henne-Bruns D,
    7. Agaimy A,
    8. Schwab M and
    9. Schmieder M
    : Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST). BMC Cancer 15: 57, 2015. PMID: 25886494. DOI: 10.1186/s12885-015-1054-y
    OpenUrlCrossRef
  25. ↵
    1. Val-Bernal JF,
    2. Mayorga M,
    3. Fernández FA,
    4. Val D and
    5. Sánchez R
    : Malignant epithelial tumors observed in hernia sacs. Hernia 18: 831-835, 2014. PMID: 25053260. DOI: 10.1007/s10029-014-1283-z
    OpenUrlCrossRefPubMed
  26. ↵
    1. Roberts JA,
    2. Ho D,
    3. Ayala AG and
    4. Ro JY
    : A study of metastatic carcinoma found in hernia sacs between 2006 and 2012 at one institution. Ann Diagn Pathol 18: 71-73, 2014. PMID: 24332748. DOI: 10.1016/j.anndiagpath.2013.10.008
    OpenUrlCrossRef
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Anticancer Research: 41 (1)
Anticancer Research
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January 2021
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Inguinal GIST: A Systematic Literature Review of Primary and Metastatic Cases
EDOARDO VIRGILIO, ALFREDO ANNICCHIARICO, LORENZO PAGLIAI, ANDREA MORINI, ANDREA ROMBOLI, FILIPPO MONTALI, RENATO COSTI
Anticancer Research Jan 2021, 41 (1) 21-25; DOI: 10.21873/anticanres.14748

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Inguinal GIST: A Systematic Literature Review of Primary and Metastatic Cases
EDOARDO VIRGILIO, ALFREDO ANNICCHIARICO, LORENZO PAGLIAI, ANDREA MORINI, ANDREA ROMBOLI, FILIPPO MONTALI, RENATO COSTI
Anticancer Research Jan 2021, 41 (1) 21-25; DOI: 10.21873/anticanres.14748
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Keywords

  • Gastrointestinal stromal tumor
  • GIST
  • inguinal hernia
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  • review
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