Table of Contents

Experimental Studies

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  Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells

  ANUSHA THADI, LAUREN LEWIS, EVE GOLDSTEIN, ANSHU AGGARWAL, MARIAN KHALILI, LINDSAY STEELE, BORIS POLYAK, SHABNAM SEYDAFKAN, MARTIN H. BLUTH, KRISTINE A. WARD, MICHAEL STYLER, PAUL M. CAMPBELL, MATTHEW R. PINCUS and WILBUR B. BOWNE

  Anticancer Research September 2020, 40 (9) 4857-4867; DOI: https://doi.org/10.21873/anticanres.14488
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  Adjuvant Oral Recombinant Methioninase Inhibits Lung Metastasis in a Surgical Breast-Cancer Orthotopic Syngeneic Model

  NORIHIKO SUGISAWA, KAZUYUKI HAMADA, QINGHONG HAN, JUN YAMAMOTO, YU SUN, HIROTO NISHINO, KEI KAWAGUCHI, MICHAEL BOUVET, MICHIAKI UNNO and ROBERT M. HOFFMAN

  Anticancer Research September 2020, 40 (9) 4869-4874; DOI: https://doi.org/10.21873/anticanres.14489
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  A Potential Mechanism of Anticancer Immune Response Coincident With Immune-related Adverse Events in Patients With Renal Cell Carcinoma

  TAIGO KATO, EISUKE TOMIYAMA, YOKO KOH, MAKOTO MATSUSHITA, YUJIRO HAYASHI, KOSUKE NAKANO, YU ISHIZUYA, CONG WANG, KOJI HATANO, ATSUNARI KAWASHIMA, TAKESHI UJIKE, KEISUKE KAWASAKI, EIICHI MORII, KUNIHITO GOTOH, HIDETOSHI EGUCHI, KAZUMA KIYOTANI, KAZUTOSHI FUJITA, NORIO NONOMURA and MOTOHIDE UEMURA

  Anticancer Research September 2020, 40 (9) 4875-4883; DOI: https://doi.org/10.21873/anticanres.14490
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  Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro

  MICHITO TERATANI, SHOUTA NAKAMURA, HIROSHI SAKAGAMI, MASAKAZU FUJISE, MASASHI HASHIMOTO, NORIYUKI OKUDAIRA, KENJIRO BANDOW, YOSUKE IIJIMA, JUNKO NAGAI, YOSHIHIRO UESAWA and HIDETSUGU WAKABAYASHI

  Anticancer Research September 2020, 40 (9) 4885-4894; DOI: https://doi.org/10.21873/anticanres.14491
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  Effect of Phosphoribosyltransferase Down-regulation on Malignant Glioma Cell Characteristics

  MINORI KAMADA, KEIICHI IKEDA and YOSHINOBU MANOME

  Anticancer Research September 2020, 40 (9) 4895-4905; DOI: https://doi.org/10.21873/anticanres.14492
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  Luteolin Induces Cytotoxicity in Mix Cellularity Classical Hodgkin's Lymphoma via Caspase Activated-cell Death

  RAJENDRA GHARBARAN, ENYUAN SHANG, ONYEKWERE ONWUMERE, NAOMI CODRINGTON, EVANGELINA DANKWA SARPONG and STEPHEN REDENTI

  Anticancer Research September 2020, 40 (9) 4907-4912; DOI: https://doi.org/10.21873/anticanres.14493
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  New Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives Inhibit FAK Phosphorylation and Potentiate the Antiproliferative Effects of Gemcitabine Through Modulation of the Human Equilibrative Nucleoside Transporter-1 in Peritoneal Mesothelioma

  GIOVANNA LI PETRI, CAMILLA PECORARO, ORNELLA RANDAZZO, SILVIA ZOPPI, STELLA MARIA CASCIOFERRO, BARBARA PARRINO, DANIELA CARBONE, BTISSAME EL HASSOUNI, ANDREA CAVAZZONI, NADIA ZAFFARONI, GIROLAMO CIRRINCIONE, PATRIZIA DIANA, GODEFRIDUS J. PETERS and ELISA GIOVANNETTI

  Anticancer Research September 2020, 40 (9) 4913-4919; DOI: https://doi.org/10.21873/anticanres.14494
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  Phenothiazines and Selenocompounds: A Potential Novel Combination Therapy of Multidrug Resistant Cancer

  MÁRIÓ GAJDÁCS, MÁRTA NOVÉ, ÁKOS CSONKA, BORISZ VARGA, CARMEN SANMARTÍN, ENRIQUE DOMÍNGUEZ-ÁLVAREZ and GABRIELLA SPENGLER

  Anticancer Research September 2020, 40 (9) 4921-4928; DOI: https://doi.org/10.21873/anticanres.14495
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  Discovery of a Novel Chemical Scaffold Against Mutant Isocitrate Dehydrogenase 1 (IDH1)

  CHUNG HYO KANG, SANG UN CHOI, YOU HWA SON, HEUNG KYOUNG LEE, HYE GWANG JEONG, CHANG-SOO YUN, SUNJOO AHN and CHI HOON PARK

  Anticancer Research September 2020, 40 (9) 4929-4935; DOI: https://doi.org/10.21873/anticanres.14496
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  ALK Inhibitors Do Not Increase Sensitivity to Radiation in EML4-ALK Non-small Cell Lung Cancer

  KATHRIN FLESCHUTZ, LISA WALTER, RUMO LEISTNER and LUCIE HEINZERLING

  Anticancer Research September 2020, 40 (9) 4937-4946; DOI: https://doi.org/10.21873/anticanres.14497
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  Effects of Sclareol Against Small Cell Lung Carcinoma and the Related Mechanism: In Vitro and In Vivo Studies

  HSIANG LAI CHEN, JINY YIN GONG, SHIH-CHAO LIN, SHIMING LI, YU-CHIH CHIANG, JUI-HSIANG HUNG, CHIEH-CHI YEN and CHI-CHIEN LIN

  Anticancer Research September 2020, 40 (9) 4947-4960; DOI: https://doi.org/10.21873/anticanres.14498
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  Inhibition of Retinoblastoma Cell Growth by CEP1347 Through Activation of the P53 Pathway

  KEITA TOGASHI, MASASHI OKADA, SHUHEI SUZUKI, TOMOMI SANOMACHI, SHIZUKA SEINO, MASAHIRO YAMAMOTO, HIDETOSHI YAMASHITA and CHIFUMI KITANAKA

  Anticancer Research September 2020, 40 (9) 4961-4968; DOI: https://doi.org/10.21873/anticanres.14499
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  Brucea javanica Increases Survival and Enhances Gemcitabine Efficacy in a Patient-derived Orthotopic Xenograft (PDOX) Mouse Model of Pancreatic Cancer

  HAITAO YANG, ZHONG TONG, LEI SHEN, YU SUN, ROBERT M. HOFFMAN and JUN HUANG

  Anticancer Research September 2020, 40 (9) 4969-4978; DOI: https://doi.org/10.21873/anticanres.14500
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  CDKN1A Gene Expression in Two Multiple Myeloma Cell Lines With Different P53 Functionality

  DENISA HRCKOVA DROZDKOVA, JAN GURSKY, JIRI MINARIK, IVO ÜBERALL, ZDENEK KOLAR and KATERINA SMESNY TRTKOVA

  Anticancer Research September 2020, 40 (9) 4979-4987; DOI: https://doi.org/10.21873/anticanres.14501
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  Ephemeranthol A Suppresses Epithelial to Mesenchymal Transition and FAK-Akt Signaling in Lung Cancer Cells

  NONGYAO NONPANYA, ORNJIRA PRAKHONGCHEEP, KORRAKOD PETSRI, CHOLASIT JITJAICHAM, SUCHARAT TUNGSUKRUTHAI, BOONCHOO SRITULARAK and PITHI CHANVORACHOTE

  Anticancer Research September 2020, 40 (9) 4989-4999; DOI: https://doi.org/10.21873/anticanres.14502
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  The Effects of Newly Synthesized Platinum(IV) Complexes on Cytotoxicity and Radiosensitization of Human Tumour Cells In Vitro

  MARIJA PETROVIC, SUZANA POPOVIC, DEJAN BASKIC, MILOS TODOROVIC, PREDRAG DJURDJEVIC, ALEKSANDRA RISTIC-FIRA, OTILIJA KETA, VLADANA PETKOVIC, LELA KORICANAC, DANIJELA STOJKOVIC, VERICA JEVTIC, SRECKO TRIFUNOVIC and DANIJELA TODOROVIC

  Anticancer Research September 2020, 40 (9) 5001-5013; DOI: https://doi.org/10.21873/anticanres.14503
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  Assessment of In Vitro Anti-melanoma Potential of Ephedranthus pisocarpus R.E.Fr.

  LUBNA KARINE BESERRA SANTOS, MÁRCIA DENISE ALVES VERAS, KARINNE KELLY GADELHA MARQUES, MICHEL MUALÉM DE MORAES ALVES, ANDERSON NOGUEIRA MENDES, FERNANDO AÉCIO DE AMORIM CARVALHO, MARIANNA VIEIRA SOBRAL, MARIANA HELENA CHAVES and JUAN CARLOS RAMOS GONÇALVES

  Anticancer Research September 2020, 40 (9) 5015-5024; DOI: https://doi.org/10.21873/anticanres.14504
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  A New Ciprofloxacin-derivative Inhibits Proliferation and Suppresses the Migration Ability of HeLa Cells

  MOUSTAFA FATHY, SIJIA SUN, QING-LI ZHAO, MOHAMED ABDEL-AZIZ, GAMAL EL-DIN A. ABUO-RAHMA, SURESH AWALE and TOSHIO NIKAIDO

  Anticancer Research September 2020, 40 (9) 5025-5033; DOI: https://doi.org/10.21873/anticanres.14505
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  Up-regulation of Death Receptor 5/TRAIL-R2 Mediates Apoptosis Induced by N,N’-[(3,4-dimethoxyphenyl)methylene] Biscinnamide in Cancer Cells

  HIROMI II, SUSUMU NAKATA and JUN'ICHI UENISHI

  Anticancer Research September 2020, 40 (9) 5035-5041; DOI: https://doi.org/10.21873/anticanres.14506
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  Inhibitory Effect of Eicosapentaenoic Acid on the Migration of the Esophageal Squamous Cell Carcinoma Cell Line TE-1

  HISAKO KUBOTA, TOSHIHIRO HIRAI, AKIRA YAMAUCHI, AYAKO OGO, HIDEO MATSUMOTO and TOMIO UENO

  Anticancer Research September 2020, 40 (9) 5043-5048; DOI: https://doi.org/10.21873/anticanres.14507
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  Anticancer Effect of a Spiro-acridine Compound Involves Immunomodulatory and Anti-angiogenic Actions

  SÂMIA SOUSA DUARTE, DAIANA KARLA FRADE SILVA, THAÍS MANGEON HONORATO LISBOA, RAWNY GALDINO GOUVEIA, RAFAEL CARLOS FERREIRA, RICARDO OLÍMPIO DE MOURA, JAMIRE MURIEL DA SILVA, ÉSSIA DE ALMEIDA LIMA, SANDRA RODRIGUES-MASCARENHAS, PATRICIA MIRELLA DA SILVA, DAVI FELIPE FARIAS, JULIANA ALVES DA COSTA RIBEIRO SOUZA, KARINA CARLA DE PAULA MEDEIROS, JUAN CARLOS RAMOS GONÇALVES and MARIANNA VIEIRA SOBRAL

  Anticancer Research September 2020, 40 (9) 5049-5057; DOI: https://doi.org/10.21873/anticanres.14508
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  Cetyltrimethylammonium Bromide Suppresses the Migration and Invasion of Hepatic Mahlavu Cells by Modulating Fibroblast Growth Factor Signaling

  TSAI-KUN WU, CHUNG-HUNG CHEN, WEI-TING LEE, TZU-FEN SU, YING-RU PAN, FU-MEI HUANG and CHIA-JEN LEE

  Anticancer Research September 2020, 40 (9) 5059-5069; DOI: https://doi.org/10.21873/anticanres.14509
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  Setanaxib as a Potent Hypoxia-specific Therapeutic Agent Against Liver Cancer

  SATOSHI OWADA, HITOSHI ENDO, CHISA OKADA, KAZUHIRO YOSHIDA, YUKARI SHIDA and MASAYUKI TATEMICHI

  Anticancer Research September 2020, 40 (9) 5071-5079; DOI: https://doi.org/10.21873/anticanres.14510
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  Novel Imidazo[2,1-b]oxazole Derivatives Inhibit Epithelial Cell Transformation and Triple Negative Breast Cancer Tumorigenesis

  POSHAN YUGAL BHATTARAI, CHANG-HYUN OH, GARAM KIM, MIN SOO KIM, BONG SANG LEE and HONG SEOK CHOI

  Anticancer Research September 2020, 40 (9) 5081-5090; DOI: https://doi.org/10.21873/anticanres.14511
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  YM155 Reverses Cabazitaxel Resistance in Castration-resistant Prostate Cancer by Reducing Survivin Expression

  TAKESHI MIYAO, HIDEKAZU KOIKE, YOSHITAKA SEKINE, AKIRA OHTSU, DAISUKE OKA and KAZUHIRO SUZUKI

  Anticancer Research September 2020, 40 (9) 5091-5095; DOI: https://doi.org/10.21873/anticanres.14512
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  Assessing the Anti-cancer Therapeutic Mechanism of a Herbal Combination for Breast Cancer on System-level by a Network Pharmacological Approach

  HO-SUNG LEE and DAL-SEOK OH

  Anticancer Research September 2020, 40 (9) 5097-5106; DOI: https://doi.org/10.21873/anticanres.14513
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  Anti-tumor Effect of Hedgehog Signaling Inhibitor, Vismodegib, on Castration-resistant Prostate Cancer

  AYA ISHII, KATSUMI SHIGEMURA, KOICHI KITAGAWA, SHIAN-YING SUNG, KUAN-CHOU CHEN, CHIANG YI-TE, MING-CHE LIU and MASATO FUJISAWA

  Anticancer Research September 2020, 40 (9) 5107-5114; DOI: https://doi.org/10.21873/anticanres.14514
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  Antitumor Effect of Shikonin, a PKM2 Inhibitor, in Cholangiocarcinoma Cell Lines

  UNCHALEE THONSRI, WUNCHANA SEUBWAI, SAKDA WARAASAWAPATI, SOPIT WONGKHAM, THIDARAT BOONMARS, UBON CHA'ON and CHAISIRI WONGKHAM

  Anticancer Research September 2020, 40 (9) 5115-5124; DOI: https://doi.org/10.21873/anticanres.14515
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  Anti-progressive Effects of a Series of Glycinyl and Alaninyl Triazolyl-oxazolidinones on Kelly Neuroblastoma Cell Line

  NADA A. AL-HASAWI, OLUDOTUN A. PHILLIPS, FATMA AL-AWADHI, LEYLA H. SHARAF, SANAA A. AMINE and LADISLAV NOVOTNY

  Anticancer Research September 2020, 40 (9) 5125-5140; DOI: https://doi.org/10.21873/anticanres.14516
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  Temozolomide and AZD7762 Induce Synergistic Cytotoxicity Effects on Human Glioma Cells

  YUN CHEN, BOR-JIUN TSENG, YA-HUI TSAI and SHENG-HONG TSENG

  Anticancer Research September 2020, 40 (9) 5141-5149; DOI: https://doi.org/10.21873/anticanres.14517
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  Static Magnetic Stimulation Induces Cell-type Specific Alterations in the Viability of SH-SY5Y Neuroblastoma Cell Line

  HELOUISE R. MEDEIROS, JOSÉ A. F. ASSUMPCAO, LICIANE F. MEDEIROS, MARTINA STAPENHORST, LARA NUNES, NICOLE A.C. HENCKES, CAROLINA URIBE CRUZ, FELIPE FREGNI, PAULO R.S. SANCHES, FERNANDA S.O. OLIVEIRA, WOLNEI CAUMO, ELIZABETH O. CIRNE-LIMA and IRACI L.S. TORRES

  Anticancer Research September 2020, 40 (9) 5151-5158; DOI: https://doi.org/10.21873/anticanres.14518
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  Redox-related Molecular Mechanism of Sensitizing Colon Cancer Cells to Camptothecin Analog SN38

  BILIANA NIKOLOVA, SEVERINA SEMKOVA, IANA TSONEVA, ELENA STOYANOVA, PAVEL LEFTEROV, DESSISLAVA LAZAROVA, ZHIVKO ZHELEV, ICHIO AOKI, TATSUYA HIGASHI and RUMIANA BAKALOVA

  Anticancer Research September 2020, 40 (9) 5159-5170; DOI: https://doi.org/10.21873/anticanres.14519
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  Inhibitory Effects of Beraprost Sodium in Murine Hepatic Sinusoidal Obstruction Syndrome

  MAKOTO NAKURA, TOMOHARU MIYASHITA, YASUHIKO YAMAMOTO, SATOSHI TAKADA, SHUNSUKE KANOU, HIDEHIRO TAJIMA, HIROYUKI TAKAMURA and TETSUO OHTA

  Anticancer Research September 2020, 40 (9) 5171-5180; DOI: https://doi.org/10.21873/anticanres.14520
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  Advanced Non-linear Mathematical Model for the Prediction of the Activity of a Putative Anticancer Agent in Human-to-mouse Cancer Xenografts

  SOTIRIOS G. LILIOPOULOS, GEORGE S. STAVRAKAKIS and KONSTANTINOS S. DIMAS

  Anticancer Research September 2020, 40 (9) 5181-5189; DOI: https://doi.org/10.21873/anticanres.14521
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  Methylsulfonylmethane Induces Cell Cycle Arrest and Apoptosis, and Suppresses the Stemness Potential of HT-29 Cells

  DOH HOON KIM, DONG YOUNG KANG, NIPIN SP, EUN SEONG JO, ALEXIS RUGAMBA, KYOUNG-JIN JANG and YOUNG MOK YANG

  Anticancer Research September 2020, 40 (9) 5191-5200; DOI: https://doi.org/10.21873/anticanres.14522
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  Total Flavonoids Isolated from Diospyros kaki L. f. Leaves Induced Apoptosis and Oxidative Stress in Human Cancer Cells

  LI CHEN, YUHANG GUO, GHEDA ALSAIF and YING GAO

  Anticancer Research September 2020, 40 (9) 5201-5210; DOI: https://doi.org/10.21873/anticanres.14523
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  Anti-tumor Activity of the Small Molecule Inhibitor PRI-724 Against β-Catenin-activated Hepatocellular Carcinoma

  RYOSUKE GABATA, KENICHI HARADA, YUKI MIZUTANI, HIROFUMI OUCHI, KAORI YOSHIMURA, YASUNORI SATO, AZUSA KITAO, KIMINORI KIMURA, HIROYUKI KOUJI, TOMOHARU MIYASHITA, HIDEHIRO TAJIMA and TETSUO OHTA

  Anticancer Research September 2020, 40 (9) 5211-5219; DOI: https://doi.org/10.21873/anticanres.14524
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  Gamma/Delta T-Cells Enhance Carboplatin-induced Cytotoxicity Towards Advanced Bladder Cancer Cells

  YUEH PAN, YA-HSU CHIU, SHAO-CHIH CHIU, DER-YANG CHO, LIANG-MING LEE, YU-CHING WEN, JACQUELINE WHANG-PENG, CHI-HAO HSIAO and PING-HSIAO SHIH

  Anticancer Research September 2020, 40 (9) 5221-5227; DOI: https://doi.org/10.21873/anticanres.14525