Article Figures & Data
Figures
- Figure 1.
Mastication affects transcriptomes of mouse microglia. A. Volcano plots for the QC3 data sets are shown with respect to the 2-month-, 4-month-, and 8-month-fed mice groups. The shaded areas correspond to the QC4 data sets. The numbers of the gene probes of the QC3 and QC4 data sets are at the lower right of each plot. B. Clustering trees for the QC4 data sets were obtained by hierarchical clustering with uncentered correlation.
- Figure 2.
The expression profiles of the genes. 56, 6, and 12 KEGG pathways were implicated in the significant differences in the gene expressions for the 2-month-, 4-month-, and 8-month-fed mice groups, respectively. And 7 pathways were shared by 2 groups. The TNF signaling pathway (A) and the NOD-like receptor signaling pathway (B) were shared by the 2-month- and 4-month-fed groups, and the phosphatidylinositol signaling pathway (C) and the thyroid hormone signaling pathway (D) were by the 2-month- and 8-month-fed groups. The expression profiles (log2 ratio values) of the genes shared by the 2 groups in each pathway are shown with respect to all 6 individual mice that were fed with a soft diet. The numbers, which were assigned to the individual mice in the same group, correspond to those in Figure 1.
- Figure 3.
Mastication affects regulation of actin cytoskeleton in mouse microglia. The functional annotation analysis of the genes that each QC3 data set has in common showed the 2 KEGG pathways of statistical significance the regulation of actin cytoskeleton and the RAS signaling pathway. The expression profiles (log2 ratio values) of the genes selected in both pathways are shown with respect to all 6 individual mice that were fed with a soft diet. FGFR1 and VEGFA are members of RTK and GF, respectively, and FOXO4 is a synonym of AFX. The numbers, which were assigned to the individual mice in the same group, correspond to those in Figure 1.
- Figure 4.
Mastication affects expressions of mouse microglial genes implicated in health and disease. Mouse microglia genes implicated in health and disease were analyzed with respect to synaptic plasticity, neuronal programmed cell death, Alzheimer's disease, frontal temporal dementia, neuropathic pain, genes induced in the MNP, and genes suppressed in the MNP. A. The difference in the expression level of each gene was presented on a heat map for each mice group of the same feeding period. B. The mean of ratios of a mean value for two soft-diet-fed mice to that for two hard-diet-fed mice was graphed with a standard deviation for each category of health and disease. The numbers, which were assigned to the individual mice in the same group, correspond to those in Figure 1.
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