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Research ArticleExperimental Studies

MiR-196a-2 Genotypes Determine the Susceptibility and Early Onset of Childhood Acute Lymphoblastic Leukemia

CHAO-CHUN CHEN, PEI-CHEN HSU, LIANG-CHUN SHIH, YUAN-NIAN HSU, CHIEN-CHUNG KUO, CHE-YI CHAO, WEN-SHIN CHANG, CHIA-WEN TSAI, DA-TIAN BAU and JEN-SHENG PEI
Anticancer Research August 2020, 40 (8) 4465-4469; DOI: https://doi.org/10.21873/anticanres.14451
CHAO-CHUN CHEN
1Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.
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PEI-CHEN HSU
1Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.
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LIANG-CHUN SHIH
2Department of Medical Research, Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.
3Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan, R.O.C.
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YUAN-NIAN HSU
4Department of Family Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.
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CHIEN-CHUNG KUO
5Department of Pediatric Orthopedics, China Medical University Hospital, Taichung, Taiwan, R.O.C.
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CHE-YI CHAO
6Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.
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WEN-SHIN CHANG
2Department of Medical Research, Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.
7Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
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CHIA-WEN TSAI
2Department of Medical Research, Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.
7Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
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DA-TIAN BAU
2Department of Medical Research, Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C.
7Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
8Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
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  • For correspondence: datian@mail.cmuh.org.tw artbau2@gmail.com
JEN-SHENG PEI
1Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.
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  • For correspondence: datian@mail.cmuh.org.tw artbau2@gmail.com
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Abstract

Background/Aim: The roles of microRNAs (miRNAs) in tumorigenesis have attracted a lot of attention. The current study aimed at examining the association of the miR-196a-2 rs11614913 genotypes with susceptibility to childhood acute lymphoblastic leukemia (ALL) in Taiwan. Materials and Methods: This case-control investigation recruited 266 patients with childhood ALL and 266 healthy controls, and the miR-196a-2 rs11614913 genotypes of each participant were examined via the polymerase chain reaction-restriction fragment length polymorphism methodology. Results: The frequency of miR-196a-2 C allele in controls was 0.440 compared with 0.423 in ALL patients. In addition, there was no significant association between CT or CC genotypes with susceptibility to childhood ALL (OR=0.89 and 0.89, 95%CI=0.60-1.30 and 0.54-1.45, p=0.5427 and 0.6302). Furthermore, the frequencies of miR-196a-2 polymorphisms were not associated with age, gender and clinical outcomes in ALL cases. Conclusion: The miR-19a-2 genotypes are not associated with susceptibility to childhood ALL in Taiwan.

  • Childhood leukemia
  • genotype
  • miR-196a-2
  • polymorphism
  • Taiwan
  • Received June 9, 2020.
  • Revision received July 6, 2020.
  • Accepted July 8, 2020.
  • Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 40 (8)
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MiR-196a-2 Genotypes Determine the Susceptibility and Early Onset of Childhood Acute Lymphoblastic Leukemia
CHAO-CHUN CHEN, PEI-CHEN HSU, LIANG-CHUN SHIH, YUAN-NIAN HSU, CHIEN-CHUNG KUO, CHE-YI CHAO, WEN-SHIN CHANG, CHIA-WEN TSAI, DA-TIAN BAU, JEN-SHENG PEI
Anticancer Research Aug 2020, 40 (8) 4465-4469; DOI: 10.21873/anticanres.14451

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MiR-196a-2 Genotypes Determine the Susceptibility and Early Onset of Childhood Acute Lymphoblastic Leukemia
CHAO-CHUN CHEN, PEI-CHEN HSU, LIANG-CHUN SHIH, YUAN-NIAN HSU, CHIEN-CHUNG KUO, CHE-YI CHAO, WEN-SHIN CHANG, CHIA-WEN TSAI, DA-TIAN BAU, JEN-SHENG PEI
Anticancer Research Aug 2020, 40 (8) 4465-4469; DOI: 10.21873/anticanres.14451
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Keywords

  • Childhood leukemia
  • genotype
  • miR-196a-2
  • polymorphism
  • Taiwan
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