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Research ArticleClinical Studies

EGFR Mutated Lung Adenocarcinoma Metastasis to the Pancreas Mimicking Primary Pancreatic Ductal Carcinoma

CAN CAO, MAX X. KONG, MALATHY KAPALI, KOOROSH MOEZARDALAN, QIUYING SHI, ALI AZARM and JINPING LAI
Anticancer Research August 2020, 40 (8) 4401-4404; DOI: https://doi.org/10.21873/anticanres.14444
CAN CAO
1Department of Pathology and Laboratory Medicine, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, U.S.A.
2The Warren Alpert Medical School, Brown University, Providence, RI, U.S.A.
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MAX X. KONG
1Department of Pathology and Laboratory Medicine, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, U.S.A.
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MALATHY KAPALI
1Department of Pathology and Laboratory Medicine, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, U.S.A.
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KOOROSH MOEZARDALAN
3Division of Gastroenterology, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, U.S.A.
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QIUYING SHI
4Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, U.S.A.
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ALI AZARM
3Division of Gastroenterology, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, U.S.A.
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JINPING LAI
1Department of Pathology and Laboratory Medicine, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, U.S.A.
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  • For correspondence: Jinping.X.Lai{at}kp.org
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    Figure 1.

    Axial computed tomography scan showing a distal pancreatic lesion (arrows) with cystic changes and ductal dilatation.

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    Figure 2.

    Endoscopic ultrasound guided fine needle aspiration (EUS-FNA) cytopathology of the pancreatic lesion showing normal pancreatic ductal epithelium (D) and clusters of atypical epithelial cells mimicking pancreatic ductal carcinoma (Diff-Quik stain, A and B left; Papanicolaou stain, B right) (A, 100×; B, 400×).

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    Figure 3.

    Endoscopic ultrasound guided fine needle aspiration and biopsy (EUS-FNAB) showing clusters of atypical epithelial proliferation in a background of fibrotic tissue (A and B, H&E stain). Immunohistochemistry: the atypical epithelial cells are positive for TTF1 (C) and Napsin A (D) (A, 40×; B-D, 400×).

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Anticancer Research
Vol. 40, Issue 8
August 2020
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EGFR Mutated Lung Adenocarcinoma Metastasis to the Pancreas Mimicking Primary Pancreatic Ductal Carcinoma
CAN CAO, MAX X. KONG, MALATHY KAPALI, KOOROSH MOEZARDALAN, QIUYING SHI, ALI AZARM, JINPING LAI
Anticancer Research Aug 2020, 40 (8) 4401-4404; DOI: 10.21873/anticanres.14444

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EGFR Mutated Lung Adenocarcinoma Metastasis to the Pancreas Mimicking Primary Pancreatic Ductal Carcinoma
CAN CAO, MAX X. KONG, MALATHY KAPALI, KOOROSH MOEZARDALAN, QIUYING SHI, ALI AZARM, JINPING LAI
Anticancer Research Aug 2020, 40 (8) 4401-4404; DOI: 10.21873/anticanres.14444
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Keywords

  • Epidermal growth factor receptor (EGFR) mutation
  • lung adenocarcinoma
  • pancreatic ductal carcinoma
  • endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and biopsy (FNB)
  • immunohistochemistry
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