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Research ArticleClinical Studies

Predictors of Postoperative Ascites After Hepatic Resection in Patients With Hepatocellular Carcinoma

NORIFUMI HARIMOTO, KENICHIRO ARAKI, NORIHIRO ISHII, RYO MURANUSHI, KOUKI HOSHINO, KEI HAGIWARA, MARIKO TSUKAGOSHI, TAKAMICHI IGARASHI, AKIRA WATANABE, NORIO KUBO and KEN SHIRABE
Anticancer Research August 2020, 40 (8) 4343-4349; DOI: https://doi.org/10.21873/anticanres.14437
NORIFUMI HARIMOTO
1Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan
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  • For correspondence: nharimotoh1{at}gunma-u.ac.jp
KENICHIRO ARAKI
1Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan
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NORIHIRO ISHII
1Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan
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RYO MURANUSHI
1Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan
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KOUKI HOSHINO
1Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan
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KEI HAGIWARA
1Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan
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MARIKO TSUKAGOSHI
1Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan
2Department of Innovative Cancer Immunotherapy, Graduate School of Medicine, Gunma University, Maebashi, Japan
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TAKAMICHI IGARASHI
1Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan
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AKIRA WATANABE
1Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan
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NORIO KUBO
1Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan
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KEN SHIRABE
1Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan
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    Figure 1.

    Incidence of postoperative (A) and refractory (B) ascites according to the MAC2-binding protein glycosylation isomer (M2BPGi) and virtual touch tissue quantification (VTQ) subgroup. In patients without both M2BPGi>1.61 and VTQ>2.62, the incidence of refractory ascites was 6.3%; in patients with both M2BPGi>1.61 and VTQ>2.62, the incidence of ascites was 64.3%. In patients without both M2BPGi>3.00 and VTQ>2.81, the incidence of refractory ascites was 0%; in patients with both M2BPGi>3.00 and VTQ>2.81, the incidence of ascites was 80.0%.

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    Figure 2.

    The relationship between MAC2-binding protein glycosylation isomer (M2BPGi) level and fibrosis stage. A: Considering the whole patient cohort, the M2BPGi level significantly increased according to the progression of fibrosis (p<0.01). B: When considering the association or not of hepatitis C virus (HCV), in patients without HCV, the M2BPGi level also significantly increased according to the progression of fibrosis (p<0.01) but in those with HCV there was no significant association between M2BPGi level and fibrosis stage. C: In patients with a sustained viral response (SVR), there was no significant association between M2BPGi level and fibrosis stage. COI: Cutoff index.

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    Figure 3.

    The relationship between virtual touch tissue quantification (VTQ) and fibrosis stage considering the whole patient cohort (A), the association or not of hepatitis C virus (HCV) (B), and a sustained viral response (SVR) (C). VTQ significantly increased according to the progression of fibrosis regardless of the HCV status and SVR.

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August 2020
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Predictors of Postoperative Ascites After Hepatic Resection in Patients With Hepatocellular Carcinoma
NORIFUMI HARIMOTO, KENICHIRO ARAKI, NORIHIRO ISHII, RYO MURANUSHI, KOUKI HOSHINO, KEI HAGIWARA, MARIKO TSUKAGOSHI, TAKAMICHI IGARASHI, AKIRA WATANABE, NORIO KUBO, KEN SHIRABE
Anticancer Research Aug 2020, 40 (8) 4343-4349; DOI: 10.21873/anticanres.14437

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Predictors of Postoperative Ascites After Hepatic Resection in Patients With Hepatocellular Carcinoma
NORIFUMI HARIMOTO, KENICHIRO ARAKI, NORIHIRO ISHII, RYO MURANUSHI, KOUKI HOSHINO, KEI HAGIWARA, MARIKO TSUKAGOSHI, TAKAMICHI IGARASHI, AKIRA WATANABE, NORIO KUBO, KEN SHIRABE
Anticancer Research Aug 2020, 40 (8) 4343-4349; DOI: 10.21873/anticanres.14437
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Keywords

  • Postoperative ascites
  • M2BPGi
  • VTQ
  • hepatic resection
  • HCC
  • ALBI grade
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