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Research ArticleClinical Studies

A Multivariable Regression Model-based Nomogram for Estimating the Overall Survival of Patients Previously Treated With Nivolumab for Advanced Non-small-cell Lung Cancer

AKIHIRO TAMIYA, MOTOHIRO TAMIYA, HIROFUMI GO, TAKAKO INOUE, KEI KUNIMASA, KENJI NAKAHAMA, YOSHIHIKO TANIGUCHI, TAKAYUKI SHIROYAMA, SHUN-ICHI ISA, KAZUMI NISHINO, TORU KUMAGAI, HIDEKAZU SUZUKI, TOMONORI HIRASHIMA, SHINJI ATAGI, AYUMI SHINTANI and FUMIO IMAMURA
Anticancer Research August 2020, 40 (8) 4229-4236; DOI: https://doi.org/10.21873/anticanres.14424
AKIHIRO TAMIYA
1Internal Medicine, Kinki-Chuo Chest Medical Center, Osaka, Japan
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MOTOHIRO TAMIYA
2Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan
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  • For correspondence: moto19781205{at}yahoo.co.jp
HIROFUMI GO
3Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan
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TAKAKO INOUE
2Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan
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KEI KUNIMASA
2Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan
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KENJI NAKAHAMA
4Respiratory Medicine, Ishikiriseiki Hospital, Osaka, Japan
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YOSHIHIKO TANIGUCHI
1Internal Medicine, Kinki-Chuo Chest Medical Center, Osaka, Japan
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TAKAYUKI SHIROYAMA
5Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan
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SHUN-ICHI ISA
6Clinical Research Center, Kinki-Chuo Chest Medical Center, Osaka, Japan
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KAZUMI NISHINO
2Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan
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TORU KUMAGAI
2Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan
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HIDEKAZU SUZUKI
7Thoracic Malignancy, Osaka Habikino Medical Center, Osaka, Japan
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TOMONORI HIRASHIMA
7Thoracic Malignancy, Osaka Habikino Medical Center, Osaka, Japan
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SHINJI ATAGI
6Clinical Research Center, Kinki-Chuo Chest Medical Center, Osaka, Japan
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AYUMI SHINTANI
3Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan
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FUMIO IMAMURA
2Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan
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    Figure 1.

    The correlation between the tumor proportion score by 22C3 and 28-8 staining assays for programmed cell death ligand 1. Kendall's rank correlation coefficient was 0.8414.

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    Figure 2.

    Nanogram based on multivariate analysis developed for overall survival of patients after starting nivolumab therapy. To use this nomogram, a vertical line is drawn upward to the Points bar is used to identify the points for each. Based on the sum of the points, a line is drawn vertically downward from the Total points bar to calculate the hazard ratio (HR). Points were assigned from the Points scale according to the following factors: Baseline age: from 25 years old; sex: female 0, male 1; EGFR mutation: none 0, present 1; histology: adenocarcinoma 1, squamous 2, other 3; PS: PS 0-1 0, PS 2-4 1; stage: other (stage III, recurrence after surgery) 0, stage IV 1; smoking history: none 0, 1 positive; LDH, according to LDH level (U/l); ALI: according to the ALI score; steroid use: none 0, present 1; Liver: no liver metastasis 0, liver metastasis 1; last response: not progressive disease 0, progressive disease 1; IHC 22C3, programmed cell death ligand 1 staining: unknown/0% 0, 1-49% 1, >50% 2.

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Anticancer Research
Vol. 40, Issue 8
August 2020
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A Multivariable Regression Model-based Nomogram for Estimating the Overall Survival of Patients Previously Treated With Nivolumab for Advanced Non-small-cell Lung Cancer
AKIHIRO TAMIYA, MOTOHIRO TAMIYA, HIROFUMI GO, TAKAKO INOUE, KEI KUNIMASA, KENJI NAKAHAMA, YOSHIHIKO TANIGUCHI, TAKAYUKI SHIROYAMA, SHUN-ICHI ISA, KAZUMI NISHINO, TORU KUMAGAI, HIDEKAZU SUZUKI, TOMONORI HIRASHIMA, SHINJI ATAGI, AYUMI SHINTANI, FUMIO IMAMURA
Anticancer Research Aug 2020, 40 (8) 4229-4236; DOI: 10.21873/anticanres.14424

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A Multivariable Regression Model-based Nomogram for Estimating the Overall Survival of Patients Previously Treated With Nivolumab for Advanced Non-small-cell Lung Cancer
AKIHIRO TAMIYA, MOTOHIRO TAMIYA, HIROFUMI GO, TAKAKO INOUE, KEI KUNIMASA, KENJI NAKAHAMA, YOSHIHIKO TANIGUCHI, TAKAYUKI SHIROYAMA, SHUN-ICHI ISA, KAZUMI NISHINO, TORU KUMAGAI, HIDEKAZU SUZUKI, TOMONORI HIRASHIMA, SHINJI ATAGI, AYUMI SHINTANI, FUMIO IMAMURA
Anticancer Research Aug 2020, 40 (8) 4229-4236; DOI: 10.21873/anticanres.14424
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Keywords

  • non-small-cell lung cancer
  • nivolumab
  • nomogram
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