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Research ArticleExperimental Studies

Determination of Immediate vs. Kinetic Growth Retardation in Physically Plasma-treated Cells by Experimental and Modelling Data

LYUBOMIR HARALAMBIEV, ARNAB BANDYOPHADYAY, BETTINA SUCHY, MARTIN WEISS, AXEL KRAMER, SANDER BEKESCHUS, AXEL EKKERNKAMP, ALEXANDER MUSTEA, LARS KADERALI and MATTHIAS B. STOPE
Anticancer Research July 2020, 40 (7) 3743-3749; DOI: https://doi.org/10.21873/anticanres.14363
LYUBOMIR HARALAMBIEV
1Department of Trauma, Reconstructive Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany
2Department of Trauma and Orthopaedic Surgery, BG Klinikum Unfallkrankenhaus Berlin gGmbH, Berlin, Germany
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ARNAB BANDYOPHADYAY
3Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany
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BETTINA SUCHY
1Department of Trauma, Reconstructive Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany
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MARTIN WEISS
4Department of Women's Health Tübingen, Tübingen, Germany
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AXEL KRAMER
5Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany
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SANDER BEKESCHUS
6ZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP Greifswald), Greifswald, Germany
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AXEL EKKERNKAMP
1Department of Trauma, Reconstructive Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany
2Department of Trauma and Orthopaedic Surgery, BG Klinikum Unfallkrankenhaus Berlin gGmbH, Berlin, Germany
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ALEXANDER MUSTEA
7Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany
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LARS KADERALI
3Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany
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MATTHIAS B. STOPE
7Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany
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  • For correspondence: matthias.stope@ukbonn.de
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Abstract

Background/Aim: The antiproliferative effects of cold atmospheric plasma (CAP) make it a promising application option in oncology. The aim of the present study was to examine whether short-term CAP treatment leads to an initial partial elimination of the treated cells or to long-term impairement and inhibition of cell growth. Materials and Methods: Cells were treated with CAP and biostatistical modelling was used to estimate growth rates over the incubation time. Four cell lines (U2-OS and MNNG osteosarcoma cells, 3T3 fibroblasts, HaCaT keratinocytes) and three CAP sources (MiniJet-R, kINPen MED, Maxium) were used. Results: The antiproliferative efficacy of CAP was due to a significant reduction in cell count during treatment and the long-lasting inhibition of growth rate in the remaining cells, detectable in all cell lines and after treatment using all three CAP devices. Conclusion: Induction of cell death and inhibition of cell growth are part of a general mechanism of biological CAP efficacy. However, data contradict the hypothesis that cancer cells respond more sensitively to CAP treatment compared to non-malignant cells.

  • Cold atmospheric plasma
  • antiproliferative effect
  • cell growth inhibition
  • growth rate
  • Received May 26, 2020.
  • Revision received June 15, 2020.
  • Accepted June 16, 2020.
  • Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 40 (7)
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Determination of Immediate vs. Kinetic Growth Retardation in Physically Plasma-treated Cells by Experimental and Modelling Data
LYUBOMIR HARALAMBIEV, ARNAB BANDYOPHADYAY, BETTINA SUCHY, MARTIN WEISS, AXEL KRAMER, SANDER BEKESCHUS, AXEL EKKERNKAMP, ALEXANDER MUSTEA, LARS KADERALI, MATTHIAS B. STOPE
Anticancer Research Jul 2020, 40 (7) 3743-3749; DOI: 10.21873/anticanres.14363

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Determination of Immediate vs. Kinetic Growth Retardation in Physically Plasma-treated Cells by Experimental and Modelling Data
LYUBOMIR HARALAMBIEV, ARNAB BANDYOPHADYAY, BETTINA SUCHY, MARTIN WEISS, AXEL KRAMER, SANDER BEKESCHUS, AXEL EKKERNKAMP, ALEXANDER MUSTEA, LARS KADERALI, MATTHIAS B. STOPE
Anticancer Research Jul 2020, 40 (7) 3743-3749; DOI: 10.21873/anticanres.14363
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Keywords

  • cold atmospheric plasma
  • antiproliferative effect
  • cell growth inhibition
  • growth rate
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