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Research ArticleExperimental Studies

Modulation of Estrogen α and Progesterone Receptors in Triple Negative Breast Cancer Cell Lines: The Effects of Vorinostat and Indole-3-Carbinol In Vitro

FATEMEH NOURIEMAMZADEN, BEVERLY WORD, EBONY COTTON, ANFERNEE HAWKINS, KAI LITTLEJOHN, RHONDA MOORE, GUSTAV MIRANDA-CARBON, CHINNA NNEKA ORISH and BEVERLY LYN-COOK
Anticancer Research July 2020, 40 (7) 3669-3683; DOI: https://doi.org/10.21873/anticanres.14356
FATEMEH NOURIEMAMZADEN
1Division of Biochemical Toxicology, FDA/NCTR, Jefferson, AR, U.S.A.
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BEVERLY WORD
1Division of Biochemical Toxicology, FDA/NCTR, Jefferson, AR, U.S.A.
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EBONY COTTON
1Division of Biochemical Toxicology, FDA/NCTR, Jefferson, AR, U.S.A.
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ANFERNEE HAWKINS
1Division of Biochemical Toxicology, FDA/NCTR, Jefferson, AR, U.S.A.
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KAI LITTLEJOHN
1Division of Biochemical Toxicology, FDA/NCTR, Jefferson, AR, U.S.A.
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RHONDA MOORE
2Division of Nonprescription Drugs, FDA/Center for Drug Evaluation Research, White Oak, MD, U.S.A.
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GUSTAV MIRANDA-CARBON
3Division of Hematology-Oncology, University of Tennessee Health Science Center, Memphis, TN, U.S.A.
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CHINNA NNEKA ORISH
4Department of Anatomy, Faculty of Basic Medical Sciences, University of Port-Harcourt, Port Harcourt, Nigeria
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BEVERLY LYN-COOK
1Division of Biochemical Toxicology, FDA/NCTR, Jefferson, AR, U.S.A.
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  • For correspondence: Beverly.lyn-cook@fda.hhs.gov
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Abstract

Background/Aim: Triple negative cancer (TNBC) is a subtype of breast cancer that is highly aggressive, with poor prognosis and responds differently to treatments. This study investigated the role of vorinostat and indole-3-carbinol (I3C) on regulating critical receptors that are not normally expressed in TNBC. Materials and Methods: Using real-time PCR, immunostaining, and western blots, the re-expression of estrogen receptor α (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2) receptors was examined in four different TNBC cell types. Results: ERα was re-expressed in three subtypes using vorinostat and I3C. Re-expression of the PR by vorinostat was also detected. Neither vorinostat nor I3C resulted in re-expression of the HER2 receptor. A significant decrease in growth and sensitivity to tamoxifen was also noted. Conclusion: The results of this study show that vorinostat and I3C modulate the re-expression of critical receptors in certain subtypes of TNBC through several pathways and these effects can be influenced by the molecular profiles of TNBCs.

  • Vorinostat
  • I3C
  • triple negative breast cancer
  • estrogen receptor
  • progesterone receptor
  • HDAC activity
  • HDAC7

Footnotes

  • This article is freely accessible online.

  • Disclaimer: The views presented in this manuscript do not necessarily reflect those of the US Food and Drug Administration.

  • Funding

    This study was funded to Beverly Lyn-Cook through a grant from the FDA-Office of Women's Health.

  • Received March 10, 2020.
  • Revision received June 15, 2020.
  • Accepted June 17, 2020.
  • Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 40 (7)
Anticancer Research
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July 2020
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Modulation of Estrogen α and Progesterone Receptors in Triple Negative Breast Cancer Cell Lines: The Effects of Vorinostat and Indole-3-Carbinol In Vitro
FATEMEH NOURIEMAMZADEN, BEVERLY WORD, EBONY COTTON, ANFERNEE HAWKINS, KAI LITTLEJOHN, RHONDA MOORE, GUSTAV MIRANDA-CARBON, CHINNA NNEKA ORISH, BEVERLY LYN-COOK
Anticancer Research Jul 2020, 40 (7) 3669-3683; DOI: 10.21873/anticanres.14356

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Modulation of Estrogen α and Progesterone Receptors in Triple Negative Breast Cancer Cell Lines: The Effects of Vorinostat and Indole-3-Carbinol In Vitro
FATEMEH NOURIEMAMZADEN, BEVERLY WORD, EBONY COTTON, ANFERNEE HAWKINS, KAI LITTLEJOHN, RHONDA MOORE, GUSTAV MIRANDA-CARBON, CHINNA NNEKA ORISH, BEVERLY LYN-COOK
Anticancer Research Jul 2020, 40 (7) 3669-3683; DOI: 10.21873/anticanres.14356
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Keywords

  • Vorinostat
  • I3C
  • Triple negative breast cancer
  • estrogen receptor
  • progesterone receptor
  • HDAC activity
  • HDAC7
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