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Research ArticleExperimental Studies

Cell Cycle Dysregulation Is Associated With 5-Fluorouracil Resistance in Gastric Cancer Cells

DA SOM KIM, KYOUNGMI MIN and SUK KYEONG LEE
Anticancer Research June 2020, 40 (6) 3247-3254; DOI: https://doi.org/10.21873/anticanres.14306
DA SOM KIM
Department of Medical Life Sciences, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
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KYOUNGMI MIN
Department of Medical Life Sciences, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
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SUK KYEONG LEE
Department of Medical Life Sciences, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
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  • For correspondence: sukklee@catholic.ac.kr
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Abstract

Background/Aim: 5-Fluorouracil (5-FU) is an anticancer drug commonly used to treat gastric cancer; however, continuous 5-FU chemotherapy causes drug resistance. Materials and Methods: We established five sublines of 5-FU-resistant AGS gastric cancer cells to investigate changes that may have occurred in the development of 5-FU resistance. Drug resistance to other chemotherapeutic reagents, proliferation, cell-cycle changes, and wound healing ability were assessed for each subline. Results: Retarded cell growth, G0/G1 phase arrest, up-regulation of p57, and down-regulation of cyclin D1 were commonly observed in all five sublines. Resistance to paclitaxel and cisplatin was also observed in most of the sublines. Conclusion: Our data support the notion that G0/G1 arrest due to changes in p57 and cyclin D1 expression may confer drug resistance, while EMT seems non-essential to 5-FU resistance in AGS gastric carcinoma cells.

  • Drug resistance
  • 5-FU
  • gastric cancer
  • EMT
  • cell cycle
  • p57
  • cyclin D1
  • Received April 13, 2020.
  • Revision received April 21, 2020.
  • Accepted April 22, 2020.
  • Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 40 (6)
Anticancer Research
Vol. 40, Issue 6
June 2020
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Cell Cycle Dysregulation Is Associated With 5-Fluorouracil Resistance in Gastric Cancer Cells
DA SOM KIM, KYOUNGMI MIN, SUK KYEONG LEE
Anticancer Research Jun 2020, 40 (6) 3247-3254; DOI: 10.21873/anticanres.14306

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Cell Cycle Dysregulation Is Associated With 5-Fluorouracil Resistance in Gastric Cancer Cells
DA SOM KIM, KYOUNGMI MIN, SUK KYEONG LEE
Anticancer Research Jun 2020, 40 (6) 3247-3254; DOI: 10.21873/anticanres.14306
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Keywords

  • drug resistance
  • 5-FU
  • gastric cancer
  • EMT
  • cell cycle
  • p57
  • cyclin D1
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