KHYG-1 Cells With EGFRvIII-specific CAR Induced a Pseudoprogression-like Feature in Subcutaneous Tumours Derived from Glioblastoma-like Cells

In vivo antitumor effect of epidermal growth factor receptor variant III (Ev)-specific chimeric antigen receptor (CAR)-expressing natural killer cell line (EvCAR-KHYG-1) cells against subcutaneous tumour xenograft derived from epidermal growth factor receptor variant III-expressing U87MG (Ev-U87MG) cells. A: Schematic representation of the experimental setting for the control (group 1) and treated (group 2) animals. PBS: Phosphate-buffered saline. B: Volume (mean±SD) of Ev-U87MG cell-derived subcutaneous tumour in control and EvCAR-KHYG-1 cell-treated groups (n=4). C: Representative haematoxylin and eosin staining of Ev-U87MG cell-derived subcutaneous tumour (left) and tumour cell occupancy (right) in control and EvCAR-KHYG-1-treated mice. Tumour cells are shown as yellow regions in the images.