Article Figures & Data
Figures
- Figure 1.
Cytopathological observations of liquid-based preparations of pleural and peritoneal fluid specimens. A: High cellularity with papillary architecture. B: Variably sized papillary fragments and clusters, with or without fibrovascular cores. C: Large, round-to-oval hyperchromatic nuclei with pleomorphism and conspicuous nucleoli. D: Frequent mitoses. E: Chemotherapy-induced atypia, including highly abnormal anaplastic nuclei more than 5 times larger than the adjacent tumor cell nuclei. Chemotherapy-induced atypia included intracytoplasmic microvacuoles (F) and large intracytoplasmic vacuoles (G) that formed perinuclear haloes and cyst-like spaces. Strong, uniform nuclear paired box 8 (H) and Wilms tumor 1 (I) expression was apparent. J: There was complete absence of p53 expression, indicating TP53 mutation. K: Lack of nuclear GATA-binding protein 3 expression was noted. Liquid-based preparation. A to G, Papanicolaou staining; H to K, polymer method. Original magnification, A, ×40; B, ×100; C, ×200; D, ×400; E to G, ×600; H to K, ×400.
- Figure 2.
Histopathological findings of a pleural biopsy obtained via video-assisted thoracoscopic surgery. A: Diffusely growing tumor cells were found, devoid of papillary architecture. They were variably sized, irregularly shaped clusters of tumor cells with infiltrating borders and obvious desmoplastic stroma. B: Intensely eosinophilic or clear cytoplasm with variably sized vacuoles, markedly pleomorphic nuclei with irregular membranes was noted, and with frequent mitotic figures and a few atypical figures. C: Coagulative tumor cell necrosis and nests or clusters of surviving tumor cells were apparent. Cells showed strong, uniform nuclear paired box 8 (D) and Wilms tumor 1 (E) expression. F: p53 Expression was completely absent, indicating TP53 mutation. G: Lack of nuclear GATA-binding protein 3 expression was noted. A to C, hematoxylin and eosin staining; D to G, polymer method. Original magnification, A, ×100; B, ×400; C, ×100; D to G, ×200.
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