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Research ArticleClinical Studies

Targeted Therapy Followed by Cytotoxic Chemotherapy in Preoperative Patients With Locally Advanced Lung Adenocarcinoma

MASAYA AOKI, KAZUHIRO UEDA, TADASHI UMEHARA, GO KAMIMURA, TAKUYA TOKUNAGA, AYA HARADA-TAKEDA, KOKI MAEDA, TOSHIYUKI NAGATA, NAOYA YOKOMAKURA, KOTA KARIATSUMARI, YUTO NONAKA, NOBUHIRO IMAMURA, SHOICHIRO MORIZONO and MASAMI SATO
Anticancer Research May 2020, 40 (5) 2911-2916; DOI: https://doi.org/10.21873/anticanres.14268
MASAYA AOKI
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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KAZUHIRO UEDA
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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  • For correspondence: k7433286@kadai.jp
TADASHI UMEHARA
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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GO KAMIMURA
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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TAKUYA TOKUNAGA
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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AYA HARADA-TAKEDA
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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KOKI MAEDA
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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TOSHIYUKI NAGATA
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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NAOYA YOKOMAKURA
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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KOTA KARIATSUMARI
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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YUTO NONAKA
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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NOBUHIRO IMAMURA
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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SHOICHIRO MORIZONO
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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MASAMI SATO
Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan
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Abstract

Background: Although oncogene-targeted therapy is a first-line treatment for advanced, unresectable lung adenocarcinoma harboring a target gene mutation, its effect on potentially resectable, locally advanced lung adenocarcinoma remains unclear. Patients and Methods: Ten patients with clinically diagnosed stage III lung adenocarcinoma harboring a target gene mutation were enrolled in the current feasibility study of targeted therapy followed by cytotoxic chemotherapy (platinum and pemetrexed) before radical surgery. Results: Complete resection was accomplished in all nine patients who went on to surgery (one patient refused surgery), and all of these patients recovered without major postoperative complications. Overall, almost all of the patients who underwent surgery remain disease-free after a median follow-up of 22 months since the initial treatment, with only one patient dying of recurrence. Conclusion: Radical surgery after the sequential use of cytostatic and cytotoxic drugs resulted in a favorable short-term outcome.

  • Lung cancer
  • tyrosine kinase inhibitor
  • induction treatment
  • EGFR
  • Received February 27, 2020.
  • Revision received March 17, 2020.
  • Accepted March 18, 2020.
  • Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 40 (5)
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Targeted Therapy Followed by Cytotoxic Chemotherapy in Preoperative Patients With Locally Advanced Lung Adenocarcinoma
MASAYA AOKI, KAZUHIRO UEDA, TADASHI UMEHARA, GO KAMIMURA, TAKUYA TOKUNAGA, AYA HARADA-TAKEDA, KOKI MAEDA, TOSHIYUKI NAGATA, NAOYA YOKOMAKURA, KOTA KARIATSUMARI, YUTO NONAKA, NOBUHIRO IMAMURA, SHOICHIRO MORIZONO, MASAMI SATO
Anticancer Research May 2020, 40 (5) 2911-2916; DOI: 10.21873/anticanres.14268

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Targeted Therapy Followed by Cytotoxic Chemotherapy in Preoperative Patients With Locally Advanced Lung Adenocarcinoma
MASAYA AOKI, KAZUHIRO UEDA, TADASHI UMEHARA, GO KAMIMURA, TAKUYA TOKUNAGA, AYA HARADA-TAKEDA, KOKI MAEDA, TOSHIYUKI NAGATA, NAOYA YOKOMAKURA, KOTA KARIATSUMARI, YUTO NONAKA, NOBUHIRO IMAMURA, SHOICHIRO MORIZONO, MASAMI SATO
Anticancer Research May 2020, 40 (5) 2911-2916; DOI: 10.21873/anticanres.14268
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Keywords

  • Lung cancer
  • tyrosine kinase inhibitor
  • induction treatment
  • EGFR
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