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Research ArticleExperimental Studies

Alteration of Cell Surface Markers CD38 and CD138 in Lymphoproliferative Disorders in the Ocular Adnexa

YUKA SUIMON, SATORU KASE, ICHIRO MIURA, KAN ISHIJIMA and SUSUMU ISHIDA
Anticancer Research April 2020, 40 (4) 2019-2023; DOI: https://doi.org/10.21873/anticanres.14158
YUKA SUIMON
1Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
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SATORU KASE
1Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
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  • For correspondence: kaseron{at}med.hokudai.ac.jp
ICHIRO MIURA
2Department of Diagnostic Pathology, Social Welfare Corporation Hokkaido Institutional Society Obihiro Hospital, Obihiro, Japan
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KAN ISHIJIMA
1Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
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SUSUMU ISHIDA
1Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
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    Figure 1.

    Correlations between CD38 and CD138 percentages. The percentages of CD38- and CD138-positive cells calculated using FCM analysis had a strong positive correlation in EMZL tissues (rs=0.78, p=0.001) (A), but not in IgG4-ROD (rs=−0.03, p=0.93) (B). In all the cases of EMZL and IgG4-ROD, CD38 and CD138 percentages had a moderate positive correlation (rs=0.54, p=0.007) (C).

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    Figure 2.

    Double-staining FCM analysis for CD38, a marker for activated T cells, plasma cells and NK cells, and CD5, a representative T cell marker, in 2 cases with IgG4-ROD. In one case, the rate of CD38 and CD5 double positive cells was 45% (A). In the other case, it was 20% (B).

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Anticancer Research
Vol. 40, Issue 4
April 2020
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Alteration of Cell Surface Markers CD38 and CD138 in Lymphoproliferative Disorders in the Ocular Adnexa
YUKA SUIMON, SATORU KASE, ICHIRO MIURA, KAN ISHIJIMA, SUSUMU ISHIDA
Anticancer Research Apr 2020, 40 (4) 2019-2023; DOI: 10.21873/anticanres.14158

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Alteration of Cell Surface Markers CD38 and CD138 in Lymphoproliferative Disorders in the Ocular Adnexa
YUKA SUIMON, SATORU KASE, ICHIRO MIURA, KAN ISHIJIMA, SUSUMU ISHIDA
Anticancer Research Apr 2020, 40 (4) 2019-2023; DOI: 10.21873/anticanres.14158
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Keywords

  • flow cytometry
  • IgG4-related ophthalmic disease
  • lymphoma
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