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Review ArticleReviewsR

The Mystery of Chemotherapy Brain: Kynurenines, Tubulin and Biophoton Release

PETER P. SORDILLO and LAURA A. SORDILLO
Anticancer Research March 2020, 40 (3) 1189-1200; DOI: https://doi.org/10.21873/anticanres.14061
PETER P. SORDILLO
1Department of Hematology-Oncology, Lenox Hill Hospital, New York, NY, U.S.A.
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  • For correspondence: peldv1@gmail.com
LAURA A. SORDILLO
2Departments of Physics and Electrical Engineering, The City College of New York, New York, NY, U.S.A.
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Abstract

The majority of patients receiving chemotherapy experience post-chemotherapy cognitive impairment, sometimes referred to as “chemo brain” or “chemo fog.” The cognitive impairment associated with this syndrome can be severe, and can sometimes last for many years after therapy discontinuation. Despite extensive investigations, its etiology is unknown. We argue that chemo brain results from damage to tubulin within microtubules. This damage can occur directly from tubulin inhibitors such as taxanes, epothilones or vinca alkaloids. Other chemotherapies stimulate increased mitochondrial activity and biophoton release. This results in abnormal tryptophan metabolism and excess production of neurotoxic kynurenines, which, in turn, damage microtubules.

  • Chemo brain
  • tryptophan
  • kynurenine
  • NAD
  • tubulin
  • cognition
  • biophoton
  • review
  • Received January 29, 2020.
  • Revision received February 7, 2020.
  • Accepted February 12, 2020.
  • Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 40 (3)
Anticancer Research
Vol. 40, Issue 3
March 2020
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The Mystery of Chemotherapy Brain: Kynurenines, Tubulin and Biophoton Release
PETER P. SORDILLO, LAURA A. SORDILLO
Anticancer Research Mar 2020, 40 (3) 1189-1200; DOI: 10.21873/anticanres.14061

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The Mystery of Chemotherapy Brain: Kynurenines, Tubulin and Biophoton Release
PETER P. SORDILLO, LAURA A. SORDILLO
Anticancer Research Mar 2020, 40 (3) 1189-1200; DOI: 10.21873/anticanres.14061
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  • Article
    • Abstract
    • Pro-inflammatory Cytokines
    • Mitochondrial Biophoton Emission
    • Tryptophan Fluorescence
    • Microtubules
    • Post-anesthesia Cognitive Impairment
    • Tubulin Inhibitors and Other Chemotherapies
    • Conclusion
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Keywords

  • Chemo brain
  • tryptophan
  • kynurenine
  • NAD
  • tubulin
  • cognition
  • biophoton
  • review
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