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Research ArticleClinical Studies

Long-term Results After Neoadjuvant Chemotherapy for Breast Cancer: A Single-center Experience

MILO GIANI, IRENE RENDA, ARIANNA VALLARIO, KETTY TAVELLA, ALESSANDRO VILLANUCCI, JACOPO NORI, ERMANNO VANZI, SIMONETTA BIANCHI and TOMMASO SUSINI
Anticancer Research February 2020, 40 (2) 1079-1085; DOI: https://doi.org/10.21873/anticanres.14046
MILO GIANI
1Breast Unit, Gynecology Section, Department of Health Sciences, University of Florence, Florence, Italy
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IRENE RENDA
1Breast Unit, Gynecology Section, Department of Health Sciences, University of Florence, Florence, Italy
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ARIANNA VALLARIO
1Breast Unit, Gynecology Section, Department of Health Sciences, University of Florence, Florence, Italy
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KETTY TAVELLA
2Medical Oncology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
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ALESSANDRO VILLANUCCI
2Medical Oncology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
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JACOPO NORI
3Diagnostic Senology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
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ERMANNO VANZI
3Diagnostic Senology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
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SIMONETTA BIANCHI
4Pathology Unit, Department of Health Sciences, University of Florence, Florence, Italy
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TOMMASO SUSINI
1Breast Unit, Gynecology Section, Department of Health Sciences, University of Florence, Florence, Italy
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  • For correspondence: tommaso.susini@unifi.it
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Abstract

Background/Aim: We evaluated the efficacy of neoadjuvant chemotherapy (NACT) in reducing locally-advanced breast cancer (LABC) size, thus improving breast-conserving surgery (BCS) rates, as well as its long-term outcome. Patients and Methods: We analyzed 59 patients treated between 1999-2017 with NACT and subsequent surgery for LABC. Results: We observed a tumor size reduction in 95% of cases, resulting in downstaging in 62.7%. The average tumor shrinkage was 49%. Women with a reduction in tumor size >50% after NACT had better 10-year OS rates than women with a reduction ≤50% (p=0.025). NACT allowed to perform BCS in 44% cases, whereas the remaining 56% cases underwent mastectomy. Overall, we observed recurrences in 37.2% patients. Recurrence rates after BCS and mastectomy were 30.7% (6 loco-regional and 2 distant cases) and 42.4% (5 loco-regional and 9 distant cases), respectively (p=0.07). Conclusion: NACT confirmed its effectiveness in reducing mastectomy rates by approximately 50%, without increasing the risk of local or distant recurrences.

  • Neoadjuvant chemotherapy
  • long-term outcome
  • down-staging
  • tumor shrinkage
  • breast conserving surgery
  • recurrence
  • Received December 19, 2019.
  • Revision received January 14, 2020.
  • Accepted January 15, 2020.
  • Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Long-term Results After Neoadjuvant Chemotherapy for Breast Cancer: A Single-center Experience
MILO GIANI, IRENE RENDA, ARIANNA VALLARIO, KETTY TAVELLA, ALESSANDRO VILLANUCCI, JACOPO NORI, ERMANNO VANZI, SIMONETTA BIANCHI, TOMMASO SUSINI
Anticancer Research Feb 2020, 40 (2) 1079-1085; DOI: 10.21873/anticanres.14046

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Long-term Results After Neoadjuvant Chemotherapy for Breast Cancer: A Single-center Experience
MILO GIANI, IRENE RENDA, ARIANNA VALLARIO, KETTY TAVELLA, ALESSANDRO VILLANUCCI, JACOPO NORI, ERMANNO VANZI, SIMONETTA BIANCHI, TOMMASO SUSINI
Anticancer Research Feb 2020, 40 (2) 1079-1085; DOI: 10.21873/anticanres.14046
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Keywords

  • neoadjuvant chemotherapy
  • long-term outcome
  • down-staging
  • tumor shrinkage
  • breast conserving surgery
  • recurrence
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