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Research ArticleExperimental Studies

Interleukin-13 Promoter Genotypes and Taiwanese Breast Cancer Susceptibility

CHUNG-LIN TSAI, CHIA-WEN TSAI, WEN-SHIN CHANG, CHEN-HSIEN SU, LIANG-CHIH LIU, HWEI-CHUNG WANG, HSU-TUNG LEE, CHUN-MING YEN, JAW-CHYUN CHEN, YUN-CHI WANG, CHAO-HSUAN CHEN and DA-TIAN BAU
Anticancer Research December 2020, 40 (12) 6743-6749; DOI: https://doi.org/10.21873/anticanres.14697
CHUNG-LIN TSAI
1Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.;
2Division of Cardiac and Vascular Surgery, Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
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CHIA-WEN TSAI
1Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.;
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
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WEN-SHIN CHANG
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
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CHEN-HSIEN SU
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
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LIANG-CHIH LIU
4Department of Breast Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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HWEI-CHUNG WANG
5Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
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HSU-TUNG LEE
5Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
6Cancer Prevention Center, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
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CHUN-MING YEN
5Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
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JAW-CHYUN CHEN
7Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.;
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YUN-CHI WANG
1Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.;
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
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CHAO-HSUAN CHEN
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
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DA-TIAN BAU
1Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.;
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
8Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
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  • For correspondence: datian@mail.cmuh.org.tw artbau2@gmail.com
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Abstract

Background/Aim: The current study aimed at evaluating the contribution of IL-13 promoter rs1881457 and rs1800925 genotypes to the risk of breast cancer in Taiwan. Materials and Methods: A total of 1,232 breast cancer cases and 1,232 age-matched controls were genotyped by typical polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Results: As for IL-13 rs1881457, the rates of AA, AC and CC genotypes were 54.8, 37.9 and 7.3% among the cases, and 53.8, 38.7 and 7.5% among the healthy controls, respectively; there were no statistically significant differences between the two groups (p for trend=0.8889). Also, regarding IL-13 rs1800925, there were no statistically significant differences between the two groups either (p for trend=0.6803). Furthermore, the allelic frequencies for IL-13 rs1881457 and rs1800925 were not differentially distributed between the case and control groups (p=0.6515 and 0.8753, respectively). Conclusion: The rs1881457 and rs1800925 IL-13 promoter polymorphisms may not serve as breast cancer susceptibility determinants for Taiwanese.

Key Words:
  • Breast cancer
  • genotype
  • interleukin-13
  • polymorphism
  • Taiwan
  • Received October 10, 2020.
  • Revision received November 4, 2020.
  • Accepted November 5, 2020.
  • Copyright © 2020 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Interleukin-13 Promoter Genotypes and Taiwanese Breast Cancer Susceptibility
CHUNG-LIN TSAI, CHIA-WEN TSAI, WEN-SHIN CHANG, CHEN-HSIEN SU, LIANG-CHIH LIU, HWEI-CHUNG WANG, HSU-TUNG LEE, CHUN-MING YEN, JAW-CHYUN CHEN, YUN-CHI WANG, CHAO-HSUAN CHEN, DA-TIAN BAU
Anticancer Research Dec 2020, 40 (12) 6743-6749; DOI: 10.21873/anticanres.14697

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Interleukin-13 Promoter Genotypes and Taiwanese Breast Cancer Susceptibility
CHUNG-LIN TSAI, CHIA-WEN TSAI, WEN-SHIN CHANG, CHEN-HSIEN SU, LIANG-CHIH LIU, HWEI-CHUNG WANG, HSU-TUNG LEE, CHUN-MING YEN, JAW-CHYUN CHEN, YUN-CHI WANG, CHAO-HSUAN CHEN, DA-TIAN BAU
Anticancer Research Dec 2020, 40 (12) 6743-6749; DOI: 10.21873/anticanres.14697
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Keywords

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