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Research ArticleExperimental Studies

AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer

SHUNSUKE NAKAMURA, MITSURO KANDA, DAI SHIMIZU, CHIE TANAKA, YOSHIKUNI INOKAWA, NORIFUMI HATTORI, MASAMICHI HAYASHI, SUGURU YAMADA, GORO NAKAYAMA, KENJI OMAE, MASAHIKO KOIKE and YASUHIRO KODERA
Anticancer Research December 2020, 40 (12) 6713-6721; DOI: https://doi.org/10.21873/anticanres.14694
SHUNSUKE NAKAMURA
1Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
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MITSURO KANDA
1Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
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  • For correspondence: m-kanda{at}med.nagoya-u.ac.jp
DAI SHIMIZU
1Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
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CHIE TANAKA
1Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
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YOSHIKUNI INOKAWA
1Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
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NORIFUMI HATTORI
1Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
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MASAMICHI HAYASHI
1Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
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SUGURU YAMADA
1Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
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GORO NAKAYAMA
1Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
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KENJI OMAE
2Department of Innovative Research and Education for Clinicians and Trainees (DiRECT), Fukushima Medical University Hospital, Fukushima, Japan
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MASAHIKO KOIKE
1Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
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YASUHIRO KODERA
1Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
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    Figure 1.

    Analysis of AMIGO2 expression in 14 gastric cancer cell lines. (A) The levels of AMIGO2 mRNA in gastric cancer cell lines. (B) PCR array analysis.

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    Figure 2.

    Comparison of AMIGO2 mRNA levels in normal adjacent tissues and GC tissues as a function of UICC stage. *p<0.05.

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    Figure 3.

    Clinical significance of AMIGO2 mRNA expression. (A) Kaplan–Meier analysis of disease-free survival (DFS) and overall survival (OS) rates of the institutional and external validation cohorts. (B) Frequencies of initial recurrence after curative gastrectomy in patients according to AMIGO2 mRNA levels. *p<0.05.

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Anticancer Research
Vol. 40, Issue 12
December 2020
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AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer
SHUNSUKE NAKAMURA, MITSURO KANDA, DAI SHIMIZU, CHIE TANAKA, YOSHIKUNI INOKAWA, NORIFUMI HATTORI, MASAMICHI HAYASHI, SUGURU YAMADA, GORO NAKAYAMA, KENJI OMAE, MASAHIKO KOIKE, YASUHIRO KODERA
Anticancer Research Dec 2020, 40 (12) 6713-6721; DOI: 10.21873/anticanres.14694

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AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer
SHUNSUKE NAKAMURA, MITSURO KANDA, DAI SHIMIZU, CHIE TANAKA, YOSHIKUNI INOKAWA, NORIFUMI HATTORI, MASAMICHI HAYASHI, SUGURU YAMADA, GORO NAKAYAMA, KENJI OMAE, MASAHIKO KOIKE, YASUHIRO KODERA
Anticancer Research Dec 2020, 40 (12) 6713-6721; DOI: 10.21873/anticanres.14694
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Keywords

  • Gastric cancer
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  • prognosis
  • biomarker
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