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Research ArticleExperimental Studies

LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function

CHANG-KYU OH, JEONG JUN PARK, MIHYANG HA, HYE JIN HEO, JUNHO KANG, EUN JUNG KWON, JI WAN KANG, YOUNGJOO KIM, JIN MO KANG, SEUNG ZHOO YOON, YEJI KO, DAI SIK KO and YUN HAK KIM
Anticancer Research October 2020, 40 (10) 5601-5609; DOI: https://doi.org/10.21873/anticanres.14573
CHANG-KYU OH
1Center for Genomic Integrity, Institute for Basic Science (IBS), Ulsan, Republic of Korea
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JEONG JUN PARK
2Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
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MIHYANG HA
3Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea
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HYE JIN HEO
4Departmment of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea
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JUNHO KANG
3Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea
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EUN JUNG KWON
3Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea
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JI WAN KANG
3Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea
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YOUNGJOO KIM
3Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea
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JIN MO KANG
5Division of Vascular Surgery, Department of Surgery, Gachon University Gil Medical Center, Incheon, Republic of Korea
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SEUNG ZHOO YOON
6Department of Anesthesiology and Pain Medicine, Korea University College of Medicine, Anam Hospital, Seoul, Republic of Korea
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YEJI KO
7Department of Statistics, University of Michigan, Ann Arbor, MI, U.S.A.
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DAI SIK KO
5Division of Vascular Surgery, Department of Surgery, Gachon University Gil Medical Center, Incheon, Republic of Korea
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  • For correspondence: daisik.ko@gilhospital.com yunhak10510@pusan.ac.kr
YUN HAK KIM
3Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea
4Departmment of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea
8Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea
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  • For correspondence: daisik.ko@gilhospital.com yunhak10510@pusan.ac.kr
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Abstract

Background/Aim: Since pathways involving LRRC17 are related to the survival of patients with various cancers, we analyzed LRRC17 as a prognostic gene in serous ovarian cancer. Materials and Methods: Data were collected from Gene Expression Omnibus (GSE9891, GSE13876, and GSE26712) and The Cancer Genome Atlas (TCGA). We performed survival analyses using C statistics, area under the curve, survival plot with optimal cutoff level, and cox proportional regression. Zebrafish embryos were used as an in vivo model. Results: The prognosis of patients with high LRRC17 expression was poorer than that of patients with low LRRC17 expression. Multivariate regression analysis showed that LRRC17 expression, age, and stage were independently related with survival. Knockdown of lrrc17 reduced survival rate and delayed development in zebrafish embryos. We also found that lrrc17 is important for cell viability by protecting from p53-dependent apoptosis. Conclusion: LRRC17 could be a prognostic gene in ovarian cancer as it regulates cancer cell viability through the p53 pathway.

  • Ovarian epithelial cancer
  • LRRC17
  • survival analysis
  • zebrafish
  • apoptosis
  • gene expression omnibus
  • TCGA
  • Received August 7, 2020.
  • Revision received August 24, 2020.
  • Accepted August 25, 2020.
  • Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 40 (10)
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LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function
CHANG-KYU OH, JEONG JUN PARK, MIHYANG HA, HYE JIN HEO, JUNHO KANG, EUN JUNG KWON, JI WAN KANG, YOUNGJOO KIM, JIN MO KANG, SEUNG ZHOO YOON, YEJI KO, DAI SIK KO, YUN HAK KIM
Anticancer Research Oct 2020, 40 (10) 5601-5609; DOI: 10.21873/anticanres.14573

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LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function
CHANG-KYU OH, JEONG JUN PARK, MIHYANG HA, HYE JIN HEO, JUNHO KANG, EUN JUNG KWON, JI WAN KANG, YOUNGJOO KIM, JIN MO KANG, SEUNG ZHOO YOON, YEJI KO, DAI SIK KO, YUN HAK KIM
Anticancer Research Oct 2020, 40 (10) 5601-5609; DOI: 10.21873/anticanres.14573
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Keywords

  • Ovarian epithelial cancer
  • LRRC17
  • survival analysis
  • zebrafish
  • apoptosis
  • gene expression omnibus
  • TCGA
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