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Research ArticleExperimental Studies

Prognostic Significance of TYRO3 Receptor Tyrosine Kinase Expression in Gastric Cancer

CHIHIRO UEJIMA, MASAKI MORIMOTO, MANABU YAMAMOTO, KAZUSHI HARA, WATARU MIYAUCHI, KEN SUGEZAWA, YOICHIRO TADA, AKIMITSU TANIO, KYOICHI KIHARA, TOMOYUKI MATSUNAGA, NARUO TOKUYASU, TERUHISA SAKAMOTO, SOICHIRO HONJO, YOSHIHISA UMEKITA and YOSHIYUKI FUJIWARA
Anticancer Research October 2020, 40 (10) 5593-5600; DOI: https://doi.org/10.21873/anticanres.14572
CHIHIRO UEJIMA
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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MASAKI MORIMOTO
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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  • For correspondence: 2s.morimoto@gmail.com
MANABU YAMAMOTO
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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KAZUSHI HARA
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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WATARU MIYAUCHI
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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KEN SUGEZAWA
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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YOICHIRO TADA
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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AKIMITSU TANIO
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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KYOICHI KIHARA
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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TOMOYUKI MATSUNAGA
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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NARUO TOKUYASU
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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TERUHISA SAKAMOTO
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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SOICHIRO HONJO
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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YOSHIHISA UMEKITA
2Department of Pathology, Division of Organ Pathology, Faculty of Medicine, Tottori University, Yonago, Japan
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YOSHIYUKI FUJIWARA
1Department of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
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Abstract

Background: Despite improved treatment for gastric cancer (GC), the prognosis of advanced disease remains poor. Further investigation of the oncogenic sequence for GC is needed. Materials and Methods: The expression of TYRO3 protein tyrosine kinase in five GC cell lines was confirmed using western blotting. TYRO3 knockdown in GC cells, and bromodeoxyuridine and Transwell assays were used to examine the functions of TYRO3 in tumor proliferation and invasion. Finally, TYRO3 expression in 138 patients who underwent curative gastric resection for advanced GC (Union for International Cancer Control stage II/III) was tested by immunohistochemistry, and the association between prognosis and TYRO3 expression was analyzed. Results: TYRO3 was detected at various levels in all the tested GC cell lines. Deleting TYRO3 significantly suppressed proliferation and invasion. Immunohistochemistry revealed TYRO3 expression was an independent prognostic factor for overall survival in patients with GC. Conclusion: TYRO3 appears to mediate tumor progression and predict prognosis of patients with GC.

  • TAM
  • TYRO3
  • gastric cancer
  • prognostic factor
  • Received July 17, 2020.
  • Revision received August 8, 2020.
  • Accepted August 11, 2020.
  • Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 40 (10)
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Prognostic Significance of TYRO3 Receptor Tyrosine Kinase Expression in Gastric Cancer
CHIHIRO UEJIMA, MASAKI MORIMOTO, MANABU YAMAMOTO, KAZUSHI HARA, WATARU MIYAUCHI, KEN SUGEZAWA, YOICHIRO TADA, AKIMITSU TANIO, KYOICHI KIHARA, TOMOYUKI MATSUNAGA, NARUO TOKUYASU, TERUHISA SAKAMOTO, SOICHIRO HONJO, YOSHIHISA UMEKITA, YOSHIYUKI FUJIWARA
Anticancer Research Oct 2020, 40 (10) 5593-5600; DOI: 10.21873/anticanres.14572

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Prognostic Significance of TYRO3 Receptor Tyrosine Kinase Expression in Gastric Cancer
CHIHIRO UEJIMA, MASAKI MORIMOTO, MANABU YAMAMOTO, KAZUSHI HARA, WATARU MIYAUCHI, KEN SUGEZAWA, YOICHIRO TADA, AKIMITSU TANIO, KYOICHI KIHARA, TOMOYUKI MATSUNAGA, NARUO TOKUYASU, TERUHISA SAKAMOTO, SOICHIRO HONJO, YOSHIHISA UMEKITA, YOSHIYUKI FUJIWARA
Anticancer Research Oct 2020, 40 (10) 5593-5600; DOI: 10.21873/anticanres.14572
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Keywords

  • TAM
  • TYRO3
  • Gastric cancer
  • prognostic factor
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