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Research ArticleExperimental Studies

Curcumol Suppresses Triple-negative Breast Cancer Metastasis by Attenuating Anoikis Resistance via Inhibition of Skp2-mediated Transcriptional Addiction

CHUNG-LIANG LI, CHIA-WEI HUANG, CHIN-JU KO, SHAO-YU FANG, FU OU-YANG, MEI-REN PAN, CHI-WEN LUO and MING-FENG HOU
Anticancer Research October 2020, 40 (10) 5529-5538; DOI: https://doi.org/10.21873/anticanres.14565
CHUNG-LIANG LI
1Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
2Division of Breast Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
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CHIA-WEI HUANG
3Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
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CHIN-JU KO
1Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
2Division of Breast Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
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SHAO-YU FANG
3Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
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FU OU-YANG
1Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
2Division of Breast Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
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MEI-REN PAN
3Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
4Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
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CHI-WEN LUO
1Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
2Division of Breast Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
4Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
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  • For correspondence: mifeho@kmu.edu.tw cwlo0623@gmail.com
MING-FENG HOU
1Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
2Division of Breast Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.
3Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
4Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
5Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
6Cohort Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
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  • For correspondence: mifeho@kmu.edu.tw cwlo0623@gmail.com
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Abstract

Background/Aim: Triple-negative breast cancer (TNBC) is a unique subtype that lacks expression of several conventional biomarkers and has a higher incidence of lymph node invasion and distal metastasis among all breast cancers. Anoikis resistance is the fundamental reason behind tumor cells' survival without their attachment to the extracellular matrix and metastasis to distal organs. Therefore, finding novel anti-cancer drugs that can suppress anoikis resistance in cancer cells is critical for patients with TNBC. Materials and Methods: Curcumol, a natural compound, was used to assess whether it can inhibit the anoikis resistance and affects cell mortality and motility of IV2-1 TNBC cells. Results: Curcumol suppressed anoikis resistance and inhibited TNBC cell survival in suspension. Additionally, these anti-cancer effects induced by curcumol could be related to the YAP1/Skp2 molecular pathway. Conclusion: Curcumol is an effective Skp2-targeted therapy that attenuates anoikis resistance and metastasis in TNBC cells.

  • Triple-negative breast cancer
  • curcumol
  • anoikis
  • Skp2
  • Received June 10, 2020.
  • Revision received July 5, 2020.
  • Accepted July 9, 2020.
  • Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 40 (10)
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Curcumol Suppresses Triple-negative Breast Cancer Metastasis by Attenuating Anoikis Resistance via Inhibition of Skp2-mediated Transcriptional Addiction
CHUNG-LIANG LI, CHIA-WEI HUANG, CHIN-JU KO, SHAO-YU FANG, FU OU-YANG, MEI-REN PAN, CHI-WEN LUO, MING-FENG HOU
Anticancer Research Oct 2020, 40 (10) 5529-5538; DOI: 10.21873/anticanres.14565

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Curcumol Suppresses Triple-negative Breast Cancer Metastasis by Attenuating Anoikis Resistance via Inhibition of Skp2-mediated Transcriptional Addiction
CHUNG-LIANG LI, CHIA-WEI HUANG, CHIN-JU KO, SHAO-YU FANG, FU OU-YANG, MEI-REN PAN, CHI-WEN LUO, MING-FENG HOU
Anticancer Research Oct 2020, 40 (10) 5529-5538; DOI: 10.21873/anticanres.14565
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Keywords

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