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Research ArticleExperimental Studies

A Gemcitabine Plus 5-Fluorouracil Combination Inhibits Gastric-Cancer Liver Metastasis in a PDOX Model: A Novel Treatment Strategy

NORIHIKO SUGISAWA, HIROTO NISHINO, TAKASHI HIGUCHI, JUN HO PARK, JUN YAMAMOTO, YOSHIHIKO TASHIRO, KEI KAWAGUCHI, MICHAEL BOUVET, MICHIAKI UNNO and ROBERT M. HOFFMAN
Anticancer Research October 2020, 40 (10) 5393-5397; DOI: https://doi.org/10.21873/anticanres.14547
NORIHIKO SUGISAWA
1AntiCancer, Inc., San Diego, CA, U.S.A.
2Department of Surgery, University of California, San Diego, CA, U.S.A.
3Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
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HIROTO NISHINO
1AntiCancer, Inc., San Diego, CA, U.S.A.
2Department of Surgery, University of California, San Diego, CA, U.S.A.
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TAKASHI HIGUCHI
1AntiCancer, Inc., San Diego, CA, U.S.A.
2Department of Surgery, University of California, San Diego, CA, U.S.A.
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JUN HO PARK
1AntiCancer, Inc., San Diego, CA, U.S.A.
2Department of Surgery, University of California, San Diego, CA, U.S.A.
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JUN YAMAMOTO
1AntiCancer, Inc., San Diego, CA, U.S.A.
2Department of Surgery, University of California, San Diego, CA, U.S.A.
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YOSHIHIKO TASHIRO
1AntiCancer, Inc., San Diego, CA, U.S.A.
2Department of Surgery, University of California, San Diego, CA, U.S.A.
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KEI KAWAGUCHI
3Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
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MICHAEL BOUVET
2Department of Surgery, University of California, San Diego, CA, U.S.A.
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MICHIAKI UNNO
3Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
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  • For correspondence: all@anticancer.com m_unno@surg.med.tohoku.ac.jp
ROBERT M. HOFFMAN
1AntiCancer, Inc., San Diego, CA, U.S.A.
2Department of Surgery, University of California, San Diego, CA, U.S.A.
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  • For correspondence: all@anticancer.com m_unno@surg.med.tohoku.ac.jp
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Abstract

Background/Aim: We established a new patient-derived orthotopic xenograft (PDOX) model of gastric cancer liver metastasis and evaluated the efficacy of a novel combination chemotherapy, gemcitabine (GEM) plus 5-fluorouracil (5-FU), compared to a standard regimen of oxaliplatinum (L-OHP) plus 5-FU on the liver metastasis. Materials and Methods: Patient-derived gastric cancer was established in nude mice from the patient' s surgical tumor specimen. A single tumor fragment was implanted in the liver of nude mice. The mice with tumors were treated by GEM plus 5-FU or L-OHP plus 5-FU. Results: GEM plus 5-FU or L-OHP plus 5-FU significantly and similarly inhibited tumor growth on the liver compared to the untreated control (p=0.007, p=0.02, respectively). Conclusion: GEM plus 5-FU could be a novel future clinical alternative to L-OHP plus 5-FU in gastric cancer patients who cannot tolerate platinum drugs.

  • Gastric cancer
  • liver metastasis
  • patient-derived orthotopic xenograft (PDOX)
  • nude mice
  • 5-fluorouracil
  • oxaliplatinum
  • gemcitabine
  • Received August 9, 2020.
  • Revision received August 27, 2020.
  • Accepted August 28, 2020.
  • Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
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Anticancer Research: 40 (10)
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A Gemcitabine Plus 5-Fluorouracil Combination Inhibits Gastric-Cancer Liver Metastasis in a PDOX Model: A Novel Treatment Strategy
NORIHIKO SUGISAWA, HIROTO NISHINO, TAKASHI HIGUCHI, JUN HO PARK, JUN YAMAMOTO, YOSHIHIKO TASHIRO, KEI KAWAGUCHI, MICHAEL BOUVET, MICHIAKI UNNO, ROBERT M. HOFFMAN
Anticancer Research Oct 2020, 40 (10) 5393-5397; DOI: 10.21873/anticanres.14547

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A Gemcitabine Plus 5-Fluorouracil Combination Inhibits Gastric-Cancer Liver Metastasis in a PDOX Model: A Novel Treatment Strategy
NORIHIKO SUGISAWA, HIROTO NISHINO, TAKASHI HIGUCHI, JUN HO PARK, JUN YAMAMOTO, YOSHIHIKO TASHIRO, KEI KAWAGUCHI, MICHAEL BOUVET, MICHIAKI UNNO, ROBERT M. HOFFMAN
Anticancer Research Oct 2020, 40 (10) 5393-5397; DOI: 10.21873/anticanres.14547
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Keywords

  • Gastric cancer
  • liver metastasis
  • patient-derived orthotopic xenograft (PDOX)
  • nude mice
  • 5-fluorouracil
  • oxaliplatinum
  • gemcitabine
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