Research ArticleProceedings of the Joint International Symposium “Vitamin D in Prevention and Therapy” and “Biologic Effects of Light”, 5-7 June, 2019 (Homburg/Saar, Germany)

Evaluation of Effectiveness of Ultraviolet Emitting Lamps on the Cutaneous Production of Vitamin D3: Relationship of the Lamps Vitamin D3 Producing Potential to the Production of 8-Hydroxy-2’-Deoxyguanosine and Nitric Oxide

ARASH SHIRVANI, KELLY S. PERSONS and MICHAEL F. HOLICK
Anticancer Research January 2020, 40 (1) 565-572; DOI: https://doi.org/10.21873/anticanres.13986

Article Figures & Data

Figures

  • Figure 1.
    Figure 1.

    The emission spectra of the 3 experimental UVB emitting devices. Three Heliomed model (Heliomed3-E1, E2 and E3) lamps (JK-Holding GMBH, Windhagen, Germany) were used in this study. The physical irradiance increased from Heliomed3-E1 to E3. Thus, the MED time decreased from lamps E1 to E3. The physical irradiance and IEC Erythemal Effective Irradiance of the lamp E3 was more focused on the wavelength of 297 nm.

  • Figure 2.
    Figure 2.

    Photographs of how the skin samples were prepared for the irradiation studies with the 3 JK lamps.

  • Figure 3.
    Figure 3.

    The comparison of vitamin D3 and 8-OHdG production following irradiation with the three experimental lamps.

  • Figure 4.
    Figure 4.

    The comparison of vitamin D3 and NO (nitrite) production following irradiation with the three experimental lamps.

  • Figure 5.
    Figure 5.

    The relative conversion of 7-DHC to Vitamin D3 in different skin types compared to the conversion of 7-DHC to previtamin D3 in the positive control ampule for all lamps. The figure shows that the conversion of 7-DHC to vitamin D3 in skin type II was about 90% compared to the ampule.

  • Figure 6.
    Figure 6.

    The comparison of the biological response of skin types to UV irradiation for all lamps. The ratio of 8-OHdG and NO production to vitamin D3 in skin type IV was lower than that in skin type 2.

Tables

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Evaluation of Effectiveness of Ultraviolet Emitting Lamps on the Cutaneous Production of Vitamin D3: Relationship of the Lamps Vitamin D3 Producing Potential to the Production of 8-Hydroxy-2’-Deoxyguanosine and Nitric Oxide
ARASH SHIRVANI, KELLY S. PERSONS, MICHAEL F. HOLICK
Anticancer Research Jan 2020, 40 (1) 565-572; DOI: 10.21873/anticanres.13986
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