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Research ArticleProceedings of the Joint International Symposium “Vitamin D in Prevention and Therapy” and “Biologic Effects of Light”, 5-7 June, 2019 (Homburg/Saar, Germany)

The Effect of Various Doses of Oral Vitamin D3 Supplementation on Gut Microbiota in Healthy Adults: A Randomized, Double-blinded, Dose-response Study

NIPITH CHAROENNGAM, ARASH SHIRVANI, TYLER A. KALAJIAN, ANJELI SONG and MICHAEL F. HOLICK
Anticancer Research January 2020, 40 (1) 551-556; DOI: https://doi.org/10.21873/anticanres.13984
NIPITH CHAROENNGAM
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, U.S.A.
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ARASH SHIRVANI
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, U.S.A.
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TYLER A. KALAJIAN
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, U.S.A.
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ANJELI SONG
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, U.S.A.
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MICHAEL F. HOLICK
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, U.S.A.
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  • For correspondence: mfholick@bu.edu
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    Figure 1.

    Relative abundance of Akkermansia spp. (left) and Porphyromonas spp. (right) of the participants at various levels of serum 25(OH)D at baseline of the study.

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    Figure 2.

    Relative abundance of clinically relevant bacterial genera before and after 8 weeks of intervention in all participants. Data are expressed as mean±SEM.

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    Figure 3.

    Changes in relative abundance of clinically relevant bacterial genera in participants receiving 600 IUs/day (left), 4,000 IUs/day (middle), and 10,000 IUs/day (right) of vitamin D3 for 8 weeks. Data are expressed as mean±SEM.

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Anticancer Research: 40 (1)
Anticancer Research
Vol. 40, Issue 1
January 2020
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The Effect of Various Doses of Oral Vitamin D3 Supplementation on Gut Microbiota in Healthy Adults: A Randomized, Double-blinded, Dose-response Study
NIPITH CHAROENNGAM, ARASH SHIRVANI, TYLER A. KALAJIAN, ANJELI SONG, MICHAEL F. HOLICK
Anticancer Research Jan 2020, 40 (1) 551-556; DOI: 10.21873/anticanres.13984

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The Effect of Various Doses of Oral Vitamin D3 Supplementation on Gut Microbiota in Healthy Adults: A Randomized, Double-blinded, Dose-response Study
NIPITH CHAROENNGAM, ARASH SHIRVANI, TYLER A. KALAJIAN, ANJELI SONG, MICHAEL F. HOLICK
Anticancer Research Jan 2020, 40 (1) 551-556; DOI: 10.21873/anticanres.13984
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  • Sunbeds and Melanoma Risk: Many Open Questions, Not Yet Time to Close the Debate
  • Variable Genomic and Metabolomic Responses to Varying Doses of Vitamin D Supplementation
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Show more Proceedings of the Joint International Symposium “Vitamin D in Prevention and Therapy” and “Biologic Effects of Light”, 5-7 June, 2019 (Homburg/Saar, Germany)

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Keywords

  • vitamin D3
  • 25-hydroxyivitamin D
  • Vitamin D3 supplementation
  • gut microbiota
  • randomized clinical trial
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